PMID- 33675858
OWN - NLM
STAT- MEDLINE
DCOM- 20210730
LR  - 20210730
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 150
DP  - 2021 Apr
TI  - Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal 
      epithelial barrier damage in Caco-2 cell monolayer model.
PG  - 112098
LID - S0278-6915(21)00131-9 [pii]
LID - 10.1016/j.fct.2021.112098 [doi]
AB  - Polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants (POPs). 
      They are constantly detected in foods. PBDEs can disrupt the intestinal flora, 
      but enterotoxicity is unknown. Luteolin, one kind of flavonoid, has drawn 
      increasing interest as an agent that strengthens the intestinal barrier. This 
      study aimed to evaluate the mitigating effect of luteolin on damage to the 
      intestinal barrier induced by decabromodiphenyl ether (BDE-209) in a Caco-2 cell 
      monolayer model. Results showed that luteolin mitigated BDE-209-induced damage to 
      intestinal epithelial barrier by reducing the levels of reactive oxygen species 
      (ROS), increasing the activity of superoxide dismutase (SOD) and glutathione 
      (GSH), suppressed the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6, and 
      IL-1beta), and increased the expression of tight junction (TJ) proteins (ZO-1, 
      occludin, and claudin-1). Furthermore, the protective effects were related to the 
      inhibition of extracellular regulated protein kinases (ERK) and nuclear factor 
      kappa-B (NF-kappaB)/myosin light chain kinase (MLCK) signaling pathways, and the 
      activation of nuclear factor erythroid 2-related factor 2 (Nrf2) signaling 
      pathways. This study is the first to provide strong evidence that BDE-209 can 
      damage the intestinal barrier, and we here investigated the important protective 
      effect of luteolin, which may lay the foundation for the development of luteolin 
      as a dietary supplement to strengthen the intestinal barrier.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Yuan, Jinwen
AU  - Yuan J
AD  - State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of 
      Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School 
      of Food Science, Nanchang University, Nanchang, 330047, China. Electronic 
      address: yuanjinwen95@163.com.
FAU - Che, Siyan
AU  - Che S
AD  - State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of 
      Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School 
      of Food Science, Nanchang University, Nanchang, 330047, China. Electronic 
      address: chesiyan94@163.com.
FAU - Ruan, Zheng
AU  - Ruan Z
AD  - State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of 
      Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School 
      of Food Science, Nanchang University, Nanchang, 330047, China. Electronic 
      address: ruanzheng@ncu.edu.cn.
FAU - Song, Luqing
AU  - Song L
AD  - State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of 
      Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School 
      of Food Science, Nanchang University, Nanchang, 330047, China. Electronic 
      address: 1667992479@qq.com.
FAU - Tang, Rongxue
AU  - Tang R
AD  - State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of 
      Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School 
      of Food Science, Nanchang University, Nanchang, 330047, China. Electronic 
      address: 1229655184@qq.com.
FAU - Zhang, Li
AU  - Zhang L
AD  - State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of 
      Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School 
      of Food Science, Nanchang University, Nanchang, 330047, China. Electronic 
      address: Zhangli@ncu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210303
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Cytokines)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Tight Junction Proteins)
RN  - KUX1ZNC9J2 (Luteolin)
RN  - N80BQ29A0H (decabromobiphenyl ether)
SB  - IM
MH  - Caco-2 Cells
MH  - Cell Survival/drug effects
MH  - Cytokines/genetics/metabolism
MH  - Epithelial Cells/*drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Halogenated Diphenyl Ethers/*toxicity
MH  - Humans
MH  - Intestinal Mucosa/*cytology
MH  - Luteolin/*pharmacology
MH  - Oxidative Stress
MH  - Signal Transduction
MH  - Tight Junction Proteins/genetics/metabolism
OTO - NOTNLM
OT  - Enterotoxicity
OT  - Flavonoids
OT  - Intestinal barrier
OT  - Luteolin
OT  - Polybrominated diphenyl ethers
EDAT- 2021/03/07 06:00
MHDA- 2021/07/31 06:00
CRDT- 2021/03/06 20:11
PHST- 2020/07/30 00:00 [received]
PHST- 2021/02/26 00:00 [revised]
PHST- 2021/02/28 00:00 [accepted]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/07/31 06:00 [medline]
PHST- 2021/03/06 20:11 [entrez]
AID - S0278-6915(21)00131-9 [pii]
AID - 10.1016/j.fct.2021.112098 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2021 Apr;150:112098. doi: 10.1016/j.fct.2021.112098. Epub 2021 
      Mar 3.