PMID- 33675979
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 1778-7254 (Electronic)
IS  - 1297-319X (Linking)
VI  - 88
IP  - 4
DP  - 2021 Jul
TI  - Rheumatic and musculoskeletal disorders induced by immune checkpoint inhibitors: 
      Consequences on overall survival.
PG  - 105168
LID - S1297-319X(21)00040-3 [pii]
LID - 10.1016/j.jbspin.2021.105168 [doi]
AB  - OBJECTIVES: Immune checkpoint inhibitors (ICIs) frequently induce immune related 
      adverse events (irAEs) that may be associated with more favorable clinical 
      outcomes. We aimed to evaluate the impact of all types of rheumatic adverse 
      events (AEs) on overall survival (OS) and tumor response in patients treated with 
      ICIs. METHODS: We performed a single-center retrospective observational study to 
      analyze the OS and tumor response in patients receiving ICIs who experienced a 
      rheumatic AE compared to those who did not experience any AE. RESULTS: From 
      December 2010 to September 2018, 264 patients with any cancer type were included. 
      Forty-three patients (16.3%) presented with at least one rheumatic AE. The median 
      OS of patients with rheumatic AEs was significantly higher than that of patients 
      without AEs, with 132 weeks (95% CI [69.3-not reached]) and 42.7 weeks (95% CI 
      [25.6-not reached]), respectively (P<0.01). This result remained significant 
      after multivariate analysis (HR 0.54, 95% CI [0.30-0.97], P<0.05). Also, tumor 
      response was better in patients with rheumatic AEs. CONCLUSION: The occurrence of 
      rheumatic AEs in patients treated with ICIs is associated with better survival 
      and tumor response. Therefore, it seems essential to detect rheumatic AEs as 
      early as possible to allow rapid and optimal management, given the long-term 
      response potential of these patients.
CI  - Copyright (c) 2021 Societe francaise de rhumatologie. Published by Elsevier Masson 
      SAS. All rights reserved.
FAU - Adda, Leslie
AU  - Adda L
AD  - Department of Pharmacy, Amiens University Medical Center, rue du Professeur 
      Christian Cabrol, 80000 Amiens, France. Electronic address: 
      leslie.adda@hotmail.fr.
FAU - Batteux, Benjamin
AU  - Batteux B
AD  - Regional Pharmacovigilance Centre, Department of Clinical Pharmacology, Amiens 
      University Medical Center, 80054 Amiens, France; Department of Rheumatology, 
      Saint-Quentin Medical Center, 02321 Saint-Quentin, France; MP3CV Laboratory, 
      EA7517, Jules Verne University of Picardie, 80054 Amiens, France.
FAU - Saidak, Zuzana
AU  - Saidak Z
AD  - Center for Human Biology, Amiens University Medical Center, 80054 Amiens, France; 
      CHIMERE Laboratory, EA7516, Jules Verne University of Picardie, 80054 Amiens, 
      France.
FAU - Poulet, Claire
AU  - Poulet C
AD  - Department of Pneumology, Amiens University Medical Center, 80054 Amiens, France.
FAU - Arnault, Jean-Philippe
AU  - Arnault JP
AD  - Department of Dermatology, Amiens University Medical Center, 80054 Amiens, 
      France.
FAU - Chauffert, Bruno
AU  - Chauffert B
AD  - Department of Oncology, Amiens University Medical Center, 80054 Amiens, France.
FAU - Sejourne, Alice
AU  - Sejourne A
AD  - Department of Rheumatology, Saint-Quentin Medical Center, 02321 Saint-Quentin, 
      France; Department of Oncology, Amiens University Medical Center, 80054 Amiens, 
      France.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210303
PL  - France
TA  - Joint Bone Spine
JT  - Joint bone spine
JID - 100938016
RN  - 0 (Immune Checkpoint Inhibitors)
SB  - IM
MH  - Humans
MH  - Immune Checkpoint Inhibitors
MH  - *Musculoskeletal Diseases
MH  - *Neoplasms
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Arthritis
OT  - Autoimmunity
OT  - Biomarkers
OT  - Immunotherapy
OT  - T Lymphocytes
EDAT- 2021/03/07 06:00
MHDA- 2021/06/29 06:00
CRDT- 2021/03/06 20:11
PHST- 2020/11/19 00:00 [received]
PHST- 2021/02/10 00:00 [accepted]
PHST- 2021/03/07 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/03/06 20:11 [entrez]
AID - S1297-319X(21)00040-3 [pii]
AID - 10.1016/j.jbspin.2021.105168 [doi]
PST - ppublish
SO  - Joint Bone Spine. 2021 Jul;88(4):105168. doi: 10.1016/j.jbspin.2021.105168. Epub 
      2021 Mar 3.