PMID- 33676251 OWN - NLM STAT- MEDLINE DCOM- 20210607 LR - 20210607 IS - 1873-3336 (Electronic) IS - 0304-3894 (Linking) VI - 414 DP - 2021 Jul 15 TI - Effects of polycyclic aromatic hydrocarbons and multiple metals co-exposure on the mosaic loss of chromosome Y in peripheral blood. PG - 125519 LID - S0304-3894(21)00482-9 [pii] LID - 10.1016/j.jhazmat.2021.125519 [doi] AB - Mosaic loss of chromosome Y (mLOY) is an indicator of genome instability, but the environmental stressors of mLOY remained largely unknown. In this study, we detected the internal exposure levels of 11 polycyclic aromatic hydrocarbon (PAH) metabolites and 22 metals among 888 coke-oven workers, and calculated their blood mLOY based on genome-wide SNP genotyping data and presented as median log R ratio (mLRR-Y). The generalized linear model (GLM), LASSO, and Bayesian kernel machine regression (BKMR), were used to select mLOY-relevant chemicals. The results of these models consistently suggested the negative dose-response relationships of urinary 1-hydroxynaphthalene (1-OHNa), antimony (Sb), and molybdenum (Mo) with mLRR-Y. There were no pairwise interactions between these three chemicals (P(interaction) > 0.05), but subjects with high exposure to >/= 2 kinds of these chemicals showed reducing mLRR-Y [beta(95%CI) = - 0.015(- 0.023, - 0.008)], increasing oxidative DNA damage (marked by 8-hydroxydeoxyguanosine) [beta(95%CI) = 0.625(0.454, 0.796)] and chromosome damage (marked by micronucleus frequency in lymphocytes) [frequency ratio (FR) and 95%CI = 1.146(1.047, 1.225)] than those with low exposure to all these chemicals. The combined effects of 1-OHNa, Sb, and Mo on elevating DNA damage may partly explain their joint effects on increased blood mLOY. These results provided a new insight into environmental hazards co-exposure on chromosome-Y deletions. CI - Copyright (c) 2021 Elsevier B.V. All rights reserved. FAU - Bai, Yansen AU - Bai Y AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Guan, Xin AU - Guan X AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Wei, Wei AU - Wei W AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Feng, Yue AU - Feng Y AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Meng, Hua AU - Meng H AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Li, Guyanan AU - Li G AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Li, Hang AU - Li H AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Li, Mengying AU - Li M AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Wang, Chenming AU - Wang C AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Fu, Ming AU - Fu M AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Jie, Jiali AU - Jie J AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Zhang, Xiaomin AU - Zhang X AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - He, Meian AU - He M AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Guo, Huan AU - Guo H AD - Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: ghuan5011@hust.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210224 PL - Netherlands TA - J Hazard Mater JT - Journal of hazardous materials JID - 9422688 RN - 0 (Coke) RN - 0 (Polycyclic Aromatic Hydrocarbons) SB - IM MH - Bayes Theorem MH - Chromosomes, Human, Y MH - *Coke MH - Humans MH - Male MH - Mosaicism MH - *Occupational Exposure/analysis MH - *Polycyclic Aromatic Hydrocarbons/toxicity OTO - NOTNLM OT - DNA damage OT - Joint effects OT - Metals OT - Mosaic loss of chromosome Y OT - Polycyclic aromatic hydrocarbons EDAT- 2021/03/07 06:00 MHDA- 2021/06/08 06:00 CRDT- 2021/03/06 20:18 PHST- 2020/11/23 00:00 [received] PHST- 2021/02/21 00:00 [revised] PHST- 2021/02/22 00:00 [accepted] PHST- 2021/03/07 06:00 [pubmed] PHST- 2021/06/08 06:00 [medline] PHST- 2021/03/06 20:18 [entrez] AID - S0304-3894(21)00482-9 [pii] AID - 10.1016/j.jhazmat.2021.125519 [doi] PST - ppublish SO - J Hazard Mater. 2021 Jul 15;414:125519. doi: 10.1016/j.jhazmat.2021.125519. Epub 2021 Feb 24.