PMID- 33677419
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20240226
IS  - 2210-7797 (Electronic)
IS  - 2210-7789 (Print)
IS  - 2210-7789 (Linking)
VI  - 24
DP  - 2021 Jun
TI  - Interleukin-17 induces hypertension but does not impair cerebrovascular function 
      in pregnant rats.
PG  - 50-57
LID - S2210-7789(21)00019-2 [pii]
LID - 10.1016/j.preghy.2021.02.009 [doi]
AB  - Preeclampsia affects 5-8% of pregnancies and is characterized by hypertension, 
      placental ischemia, neurological impairment, and an increase in circulating 
      inflammatory cytokines, including Interleukin-17 (IL17). While placental ischemia 
      has also been shown to impair cerebrovascular function, it is not known which 
      placental-associated factor(s) drive this effect. The purpose of this study was 
      to examine the effects of IL17 on cerebrovascular function during pregnancy. To 
      achieve this goal, pregnant rats were infused with either IL17 (150 pg/day, 
      5 days, osmotic minipump), or vehicle (saline/0.7% BSA osmotic minipump) starting 
      at gestational day (GD) 14. On GD 19, the cerebral blood flow (CBF) response to 
      increases in mean arterial pressure (MAP) was measured in vivo, and myogenic 
      constrictor responses of the middle cerebral artery (MCA) were assessed ex vivo. 
      IL17 increased MAP but impaired CBF responses only at the highest arterial 
      pressure measured (190 mmHg). Myogenic constrictor responses overall were mostly 
      unaffected by IL17 infusion; however, the intraluminal pressure at which peak 
      myogenic tone was generated was lower in the IL17 infused group (120 vs 165 mm 
      Hg), suggesting maximal tone is exerted at lower intraluminal pressures in 
      IL17-treated pregnant rats. Consistent with the lack of substantial change in 
      overall myogenic responsiveness, there was no difference in cerebral vessel 
      expression of putative mechanosensitive protein betaENaC, but a tendency towards a 
      decrease in ASIC2 (p = 0.067) in IL17 rats. This study suggests that infusion of 
      IL17 independent of other placental ischemia-associated factors is insufficient 
      to recapitulate the features of impaired cerebrovascular function during 
      placental ischemia. Further studies to examine of the role of other 
      pro-inflammatory cytokines, individually or a combination, are necessary to 
      determine mechanisms of cerebral vascular dysfunction during preeclampsia.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Duncan, Jeremy W
AU  - Duncan JW
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39206, USA.
FAU - Nemeth, Zoltan
AU  - Nemeth Z
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39206, USA.
FAU - Hildebrandt, Emily
AU  - Hildebrandt E
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39206, USA.
FAU - Granger, Joey P
AU  - Granger JP
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39206, USA.
FAU - Ryan, Michael J
AU  - Ryan MJ
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39206, USA.
FAU - Drummond, Heather A
AU  - Drummond HA
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39206, USA. Electronic address: hdrummond@umc.edu.
LA  - eng
GR  - R01 HL136684/HL/NHLBI NIH HHS/United States
GR  - P20 GM104357/GM/NIGMS NIH HHS/United States
GR  - P20 GM121334/GM/NIGMS NIH HHS/United States
GR  - U54 GM115428/GM/NIGMS NIH HHS/United States
GR  - P01 HL051971/HL/NHLBI NIH HHS/United States
GR  - T32 HL105324/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20210223
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
RN  - 0 (ASIC2 protein, human)
RN  - 0 (Acid Sensing Ion Channels)
RN  - 0 (IL17A protein, human)
RN  - 0 (Interleukin-17)
SB  - IM
MH  - Acid Sensing Ion Channels/metabolism/pharmacology
MH  - Animals
MH  - Blood Pressure
MH  - Cerebral Arteries/drug effects/metabolism
MH  - *Cerebrovascular Circulation/drug effects
MH  - Disease Models, Animal
MH  - Female
MH  - Hypertension/*physiopathology
MH  - Interleukin-17/metabolism/*pharmacology
MH  - Middle Cerebral Artery/*drug effects/metabolism
MH  - Pre-Eclampsia/*etiology
MH  - Pregnancy
MH  - Rats, Sprague-Dawley
MH  - Rats
PMC - PMC8159853
MID - NIHMS1680812
OTO - NOTNLM
OT  - ASIC2
OT  - Cerebral blood flow
OT  - IL17
OT  - Myogenic constriction
OT  - betaENaC
EDAT- 2021/03/08 06:00
MHDA- 2021/11/09 06:00
PMCR- 2022/06/01
CRDT- 2021/03/07 20:40
PHST- 2020/07/01 00:00 [received]
PHST- 2021/01/20 00:00 [revised]
PHST- 2021/02/16 00:00 [accepted]
PHST- 2021/03/08 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2021/03/07 20:40 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - S2210-7789(21)00019-2 [pii]
AID - 10.1016/j.preghy.2021.02.009 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2021 Jun;24:50-57. doi: 10.1016/j.preghy.2021.02.009. Epub 
      2021 Feb 23.