PMID- 33677932
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20221207
IS  - 2093-5978 (Electronic)
IS  - 2093-596X (Print)
IS  - 2093-596X (Linking)
VI  - 36
IP  - 1
DP  - 2021 Feb
TI  - Association of Vitamin D Deficiency with Diabetic Nephropathy.
PG  - 106-113
LID - 10.3803/EnM.2020.826 [doi]
AB  - BACKGROUND: Low 25-hydroxyvitamin D (25OHD) levels are associated with the 
      incidence of type 2 diabetes mellitus (T2DM). However, the association between 
      25OHD and metabolic health status or diabetic complications is inconclusive. We 
      evaluated this relationship between vitamin D status and metabolic parameters and 
      complications of T2DM. METHODS: This study included 1,392 patients with T2DM who 
      visited Eulji and Ewha Diabetes Center between January 2011 and August 2016. 
      Anthropometric parameters and laboratory tests including glycated hemoglobin 
      (HbA1c), lipid profile, liver and kidney function, and urinary 
      albumin-to-creatinine ratio (UACR) were evaluated. Diabetic macro- and 
      microvascular complications were determined through a medical record review. 
      Serum 25OHD concentrations were measured by chemiluminescent immunoassay. 
      RESULTS: The mean 25OHD level was 16.8+/-9.6 ng/mL. Vitamin D deficiency (<20 
      ng/mL) and severe deficiency (<10 ng/mL) were observed in 990 (71.1%) and 351 
      (25.2%) participants, respectively. 25OHD level was positively correlated with 
      age and highdensity lipoprotein cholesterol (HDL-C) level and negatively 
      correlated with HbA1c, triglyceride level, and UACR. HDL-C and UACR were 
      significantly associated with 25OHD after adjusting for other variables. Vitamin 
      D deficiency was independently related to nephropathy after adjusting for 
      confounding variables. CONCLUSION: Vitamin D deficiency was common among Korean 
      T2DM patients; it was independently associated with microalbuminuria and HDL 
      level, and positively related to diabetic nephropathy.
FAU - Hong, So-Hyeon
AU  - Hong SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Ewha 
      Womans University School of Medicine, Seoul, Korea.
FAU - Kim, Young Bin
AU  - Kim YB
AD  - Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University 
      School of Medicine, Seoul, Korea.
FAU - Choi, Hoon Sung
AU  - Choi HS
AD  - Department of Internal Medicine, Kangwon National University School of Medicine, 
      Chuncheon, Korea.
FAU - Jeong, Tae-Dong
AU  - Jeong TD
AD  - Department of Laboratory Medicine, Ewha Womans University School of Medicine, 
      Seoul, Korea.
FAU - Kim, Jin Taek
AU  - Kim JT
AD  - Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University 
      School of Medicine, Seoul, Korea.
FAU - Sung, Yeon Ah
AU  - Sung YA
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Ewha 
      Womans University School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20210224
PL  - Korea (South)
TA  - Endocrinol Metab (Seoul)
JT  - Endocrinology and metabolism (Seoul, Korea)
JID - 101554139
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Albuminuria/epidemiology
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - *Diabetic Nephropathies/epidemiology
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Republic of Korea
MH  - *Vitamin D Deficiency/epidemiology
PMC - PMC7937857
OTO - NOTNLM
OT  - Albuminuria
OT  - Diabetes complications
OT  - Diabetic nephropathies
OT  - Vitamin D
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2021/03/09 06:00
MHDA- 2022/03/15 06:00
PMCR- 2021/02/01
CRDT- 2021/03/08 00:33
PHST- 2020/08/27 00:00 [received]
PHST- 2020/12/10 00:00 [accepted]
PHST- 2021/03/08 00:33 [entrez]
PHST- 2021/03/09 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/02/01 00:00 [pmc-release]
AID - EnM.2020.826 [pii]
AID - enm-2020-826 [pii]
AID - 10.3803/EnM.2020.826 [doi]
PST - ppublish
SO  - Endocrinol Metab (Seoul). 2021 Feb;36(1):106-113. doi: 10.3803/EnM.2020.826. Epub 
      2021 Feb 24.