PMID- 33678637
OWN - NLM
STAT- MEDLINE
DCOM- 20210310
LR  - 20240321
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 46
IP  - 1
DP  - 2021 Jan 28
TI  - Changes of serum immunoglobulin level in healthy pregnant women and establishment 
      of its reference interval.
PG  - 53-59
LID - 1672-7347(2021)01-0053-07 [pii]
LID - 10.11817/j.issn.1672-7347.2021.200468 [doi]
AB  - OBJECTIVES: Pregnant women in a special physiological period, the body's blood 
      indicators will change to a certain extent. This study aims to explore the 
      changes of serum immunoglobulin levels in healthy pregnant women and establish 
      its reference interval (RI). METHODS: A total of 369 healthy pregnant women, who 
      underwent pregnancy examination in the Department of Obstetrics, Second Xiangya 
      Hospital of Central South University from August 2019 to October 2019, were 
      enrolled for this study. They were divided into an early pregnancy group, a 
      middle pregnancy group, and a late pregnancy group according to the pregnancy 
      period, and 123 healthy non-pregnant women were selected as the controls. The 
      levels of immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A 
      (IgA) were determined by immune transmission turbidities. The level of 
      immunoglobulin E (IgE) was determined by electrochemiluminescence. The 
      differences in immunoglobulin levels between pregnant women and non-pregnant 
      women and among different gestational periods were analyzed, and the RI of serum 
      immunoglobulin level during pregnancy was established. RESULTS: Compared to the 
      non-pregnant women, the levels of serum IgG, IgM, IgA, and IgE in pregnant women 
      were significantly decreased (all P<0.01), with 51.81% for IgG, 43.84% for IgM, 
      55.80% for IgA, and 49.80% for IgE. Except that the IgG level of late pregnancy 
      group was significantly lower than that of early pregnancy group (P<0.05), there 
      were no significant differences in the IgG, IgM, IgA, and IgE levels among the 
      other groups (all P>0.05). The RIs of serum IgG in early pregnancy, middle 
      pregnancy, and late pregnancy were 6.02-7.70 g/L, 5.18-6.85 g/L, and 4.58-5.72 
      g/L, respectively, while the RIs of serum IgM, IgA, and IgE were 0.71-0.93 g/L, 
      0.90-1.09 g/L, and 68.30-107.69 ng/mL, respectively in pregnant women. 
      CONCLUSIONS: The levels of immunoglobulin in pregnant women are decreased 
      significantly. The establishment of RIs of IgG, IgM, IgA and IgE in healthy 
      pregnant women could provide scientific basis for clinical decision-making.
FAU - Zhang, Tingting
AU  - Zhang T
AD  - Department of Laboratory Medicine, Second Xiangya Hospital, Central South 
      University, Changsha 410011. zhangtingting@csu.edu.cn.
FAU - Hu, Yun
AU  - Hu Y
AD  - Department of Obstetrics, Second Xiangya Hospital, Central South University, 
      Changsha 410011, China.
FAU - Xiang, Zhongyuan
AU  - Xiang Z
AD  - Department of Laboratory Medicine, Second Xiangya Hospital, Central South 
      University, Changsha 410011. xiangzhongyuan@csu.edu.cn.
LA  - eng
LA  - chi
GR  - 2020JJ4816/the Hunan Provincial Science and Technology Department, China/
PT  - Journal Article
TT  - 健康妊娠妇女血清免疫球蛋白水平的变化及其参考区间的建立.
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Female
MH  - Humans
MH  - *Immunoglobulin A
MH  - Immunoglobulin G
MH  - Immunoglobulin M
MH  - Pregnancy
MH  - *Pregnant Women
MH  - Reference Values
PMC - PMC10878290
OTO - NOTNLM
OT  - immunoglobulin A
OT  - immunoglobulin E
OT  - immunoglobulin G
OT  - immunoglobulin M
OT  - pregnant women
OT  - reference interval
COIS- The authors declare that they have no conflicts of interest to disclose.
EDAT- 2021/03/09 06:00
MHDA- 2021/03/11 06:00
PMCR- 2021/01/28
CRDT- 2021/03/08 05:46
PHST- 2021/03/08 05:46 [entrez]
PHST- 2021/03/09 06:00 [pubmed]
PHST- 2021/03/11 06:00 [medline]
PHST- 2021/01/28 00:00 [pmc-release]
AID - 1672-7347(2021)01-0053-07 [pii]
AID - 1672-7347（2021）01-0053-07 [pii]
AID - 10.11817/j.issn.1672-7347.2021.200468 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Jan 28;46(1):53-59. doi: 
      10.11817/j.issn.1672-7347.2021.200468.