PMID- 33680135
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231110
IS  - 1831-4732 (Electronic)
IS  - 1831-4732 (Linking)
VI  - 19
IP  - 2
DP  - 2021 Feb
TI  - Modification of the existing maximum residue levels for acibenzolar-S-methyl in 
      beans with pods and peas with pods.
PG  - e06430
LID - 10.2903/j.efsa.2021.6430 [doi]
LID - e06430
AB  - In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant 
      Syngenta France SAS submitted a request to the competent national authority in 
      France to amend the residue definition for risk assessment and to modify the 
      existing maximum residue levels (MRLs) for the active substance 
      acibenzolar-S-methyl in beans (with pods) and peas (with pods). The toxicological 
      data submitted in support of this MRL application were found to be sufficient to 
      conclude that the plant metabolite 4-OH acibenzolar acid is not genotoxic 
      in vitro, however lacking investigation of the general toxicity, a definitive 
      conclusion cannot be derived whether 4-OH acibenzolar acid (free and conjugated) 
      should be included or excluded from the residue definition for risk assessment 
      for all commodities belonging to the groups of leafy crops and pulses/oilseeds. 
      The data submitted in support of the request were found to be sufficient to 
      derive MRL proposals on the basis of the current residue definition (sum of 
      acibenzolar-S-methyl and acibenzolar acid (free and conjugated), expressed as 
      acibenzolar-S-methyl) for the intended uses on lettuces and salad plants, beans 
      (with pods) and peas (with pods). The available residue trials are sufficient to 
      derive MRL proposals of 1 mg/kg for beans with pods and peas with pods. The 
      submitted information did not provide evidence that the existing MRL has to be 
      changed for the intended uses on lettuces and other salad plants. For herbs and 
      edible flowers, data gaps were identified which precluded the derivation of MRL 
      proposals. The consumer risk assessment for the current residue definition did 
      not identify an unacceptable risk for consumers. The indicative exposure 
      calculations performed for the metabolite 4-OH acibenzolar indicate that exposure 
      to this metabolite is lower than the exposure to acibenzolar-S-methyl and 
      acibenzolar acid (free and conjugated). However, considering the data gaps 
      identified, a definitive conclusion cannot be derived by EFSA on the risk for 
      consumers related to the intake of residues of 4-OH acibenzolar acid. The 
      reliable end points appropriate for use in regulatory risk assessment are 
      presented.
CI  - (c) 2021 European Food Safety Authority. EFSA Journal published by John Wiley and 
      Sons Ltd on behalf of European Food Safety Authority.
CN  - EFSA (European Food Safety Authority)
FAU - Anastassiadou, Maria
AU  - Anastassiadou M
FAU - Bernasconi, Giovanni
AU  - Bernasconi G
FAU - Brancato, Alba
AU  - Brancato A
FAU - Carrasco Cabrera, Luis
AU  - Carrasco Cabrera L
FAU - Ferreira, Lucien
AU  - Ferreira L
FAU - Greco, Luna
AU  - Greco L
FAU - Jarrah, Samira
AU  - Jarrah S
FAU - Kazocina, Aija
AU  - Kazocina A
FAU - Leuschner, Renata
AU  - Leuschner R
FAU - Magrans, Jose Oriol
AU  - Magrans JO
FAU - Miron, Ileana
AU  - Miron I
FAU - Nave, Stefanie
AU  - Nave S
FAU - Pedersen, Ragnor
AU  - Pedersen R
FAU - Reich, Hermine
AU  - Reich H
FAU - Rojas, Alejandro
AU  - Rojas A
FAU - Sacchi, Angela
AU  - Sacchi A
FAU - Santos, Miguel
AU  - Santos M
FAU - Scarlato, Alessia Pia
AU  - Scarlato AP
FAU - Theobald, Anne
AU  - Theobald A
FAU - Vagenende, Benedicte
AU  - Vagenende B
FAU - Verani, Alessia
AU  - Verani A
LA  - eng
PT  - Journal Article
DEP - 20210226
PL  - United States
TA  - EFSA J
JT  - EFSA journal. European Food Safety Authority
JID - 101642076
PMC - PMC7908853
OTO - NOTNLM
OT  - MRL
OT  - acibenzolar-S-methyl
OT  - beans
OT  - consumer risk assessment
OT  - peas
OT  - pesticide
EDAT- 2021/03/09 06:00
MHDA- 2021/03/09 06:01
PMCR- 2021/02/26
CRDT- 2021/03/08 05:51
PHST- 2021/03/08 05:51 [entrez]
PHST- 2021/03/09 06:00 [pubmed]
PHST- 2021/03/09 06:01 [medline]
PHST- 2021/02/26 00:00 [pmc-release]
AID - EFS26430 [pii]
AID - 10.2903/j.efsa.2021.6430 [doi]
PST - epublish
SO  - EFSA J. 2021 Feb 26;19(2):e06430. doi: 10.2903/j.efsa.2021.6430. eCollection 2021 
      Feb.