PMID- 33682263
OWN - NLM
STAT- MEDLINE
DCOM- 20211013
LR  - 20211013
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 57
IP  - 8
DP  - 2021 Aug
TI  - Incidence of allergen-specific and total immunoglobulin E positivity in children 
      undergoing adenotonsillectomy.
PG  - 1228-1233
LID - 10.1111/jpc.15430 [doi]
AB  - AIM: To conduct a prospective, consecutive cohort study to evaluate the incidence 
      of allergen-specific and total immunoglobulin E (IgE) in a paediatric population 
      undergoing adenotonsillectomy for sleep-disordered breathing. METHODS: A total of 
      64 consecutive patients presenting for adenotonsillectomy at a single centre were 
      recruited over a period of 3 months. All patients underwent adenotonsillectomy 
      and had allergen-specific and total IgE serum testing at the time of anaesthesia 
      induction. Pre-operative history and examination were conducted to determine 
      clinical allergy. Caregivers completed the Sleep-Related Breathing Disorder scale 
      of the Paediatric Sleep Questionnaire and the Mini Rhinoconjunctivitis Quality of 
      Life Questionnaire at baseline and at 6 weeks post-operatively. RESULTS: A total 
      of 37 (57.8%) patients had either allergen-specific or total IgE positivity. 
      House dust mite was the most prevalent allergen-specific IgE finding, being 
      present in moderate to high levels in 14 (21.9%) patients. A total of 17 (26.6%) 
      patients had a history of atopy, while 34 (53.1%) had examination findings 
      suggestive of allergy. Neither serum IgE testing nor clinical history and 
      examination were independently associated with residual symptoms post 
      adenotonsillectomy. Patients with concomitant serum IgE positivity and clinical 
      allergy had higher residual symptom scores compared to those who did not using 
      both Sleep-Related Breathing Disorder scale of the Paediatric Sleep Questionnaire 
      (P = 0.035) and Mini Rhinoconjunctivitis Quality of Life Questionnaire (P = 0.02) 
      questionnaires. CONCLUSIONS: Our prospective, consecutive cohort of patients 
      reflect a greater incidence of serum IgE positivity compared to historical 
      figures. When utilised with clinical findings on history and examination, serum 
      IgE is a useful adjunct that is associated with greater residual symptoms 
      post-adenotonsillectomy.
CI  - (c) 2021 Paediatrics and Child Health Division (The Royal Australasian College of 
      Physicians).
FAU - Lam, Matthew E
AU  - Lam ME
AUID- ORCID: 0000-0001-6532-0847
AD  - Illawarra Shoalhaven Local Health District, The Wollongong Hospital, Wollongong, 
      New South Wales, Australia.
AD  - Illawarra Health Medical Research Institute, University of Wollongong, 
      Wollongong, New South Wales, Australia.
FAU - Kitipornchai, Leon
AU  - Kitipornchai L
AD  - Illawarra Shoalhaven Local Health District, The Wollongong Hospital, Wollongong, 
      New South Wales, Australia.
FAU - Ball, Natelle
AU  - Ball N
AD  - Illawarra Shoalhaven Local Health District, The Wollongong Hospital, Wollongong, 
      New South Wales, Australia.
FAU - Sarkissian, Lernik
AU  - Sarkissian L
AD  - Illawarra Shoalhaven Local Health District, The Wollongong Hospital, Wollongong, 
      New South Wales, Australia.
FAU - Sands, Terry
AU  - Sands T
AD  - Illawarra Shoalhaven Local Health District, The Wollongong Hospital, Wollongong, 
      New South Wales, Australia.
FAU - Grundy, Liam
AU  - Grundy L
AD  - Illawarra Shoalhaven Local Health District, The Wollongong Hospital, Wollongong, 
      New South Wales, Australia.
FAU - MacKay, Stuart G
AU  - MacKay SG
AD  - Illawarra Shoalhaven Local Health District, The Wollongong Hospital, Wollongong, 
      New South Wales, Australia.
LA  - eng
PT  - Journal Article
DEP - 20210308
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Allergens
MH  - Child
MH  - Cohort Studies
MH  - Humans
MH  - *Immunoglobulin E
MH  - Incidence
MH  - Prospective Studies
MH  - Quality of Life
OTO - NOTNLM
OT  - allergic rhinitis
OT  - immunoglobulin E
OT  - incidence
OT  - radioallergosorbent test
OT  - sleep-disordered breathing
OT  - tonsillectomy
EDAT- 2021/03/09 06:00
MHDA- 2021/10/14 06:00
CRDT- 2021/03/08 06:02
PHST- 2021/02/19 00:00 [revised]
PHST- 2020/01/10 00:00 [received]
PHST- 2021/02/22 00:00 [accepted]
PHST- 2021/03/09 06:00 [pubmed]
PHST- 2021/10/14 06:00 [medline]
PHST- 2021/03/08 06:02 [entrez]
AID - 10.1111/jpc.15430 [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2021 Aug;57(8):1228-1233. doi: 10.1111/jpc.15430. Epub 
      2021 Mar 8.