PMID- 33683858
OWN - NLM
STAT- MEDLINE
DCOM- 20210720
LR  - 20210720
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 13
IP  - 10
DP  - 2021 Mar 17
TI  - Multifunctional Nanoprobe for the Delivery of Therapeutic siRNA and Real-Time 
      Molecular Imaging of Parkinson's Disease Biomarkers.
PG  - 11609-11620
LID - 10.1021/acsami.0c22112 [doi]
AB  - Parkinson's disease (PD) has been recently associated with the excessive 
      expression of matrix metalloproteinase 3 (MMP3). One of the major challenges in 
      treating PD is to effectively detect and inhibit the early MMP3 activities to 
      relieve the neural stress and inflammation responses. Previously, numerous 
      upconversion nanoparticle (UCNP)-based nanoprobes have been designed for the 
      detection of biomarkers in neurodegenerative diseases. To further improve the 
      performance of the conventional nanoprobes, we introduced novel reporting units 
      and integrated the therapeutic reagents to fabricate a theragnostic platform for 
      PD and other neurodegenerative diseases. Here, we designed a multifunctional 
      UCNP/aggregation-induced emission luminogen (AIEgen)-based nanoprobe to 
      effectively detect the time-lapse MMP3 activities in the inflammatory 
      catecholaminergic SH-SY5Y cells and simultaneously deliver the MMP3-siRNA into 
      the stressed catecholaminergic SH-SY5Y cells, inhibiting the MMP3-induced 
      inflammatory neural responses. The unique features of our UCNP/AIEgen-based 
      nanoprobe platform shed light on the development of a novel theragnostic probe 
      for the early diagnosis and cure of neurodegenerative diseases.
FAU - Li, Rui
AU  - Li R
AD  - Department of Biomedical Engineering, The Chinese University of Hong Kong, 
      Shatin, New Territories, 999077 Hong Kong, P. R. China.
FAU - Li, Yi
AU  - Li Y
AD  - School of Biomedical Sciences, Faculty of Medicine, The Chinese University of 
      Hong Kong, Shatin, New Territories, 999077 Hong Kong, P. R. China.
FAU - Mu, Mingdao
AU  - Mu M
AD  - School of Biomedical Sciences, Faculty of Medicine, The Chinese University of 
      Hong Kong, Shatin, New Territories, 999077 Hong Kong, P. R. China.
FAU - Yang, Boguang
AU  - Yang B
AD  - Department of Biomedical Engineering, The Chinese University of Hong Kong, 
      Shatin, New Territories, 999077 Hong Kong, P. R. China.
FAU - Chen, Xiaoyu
AU  - Chen X
AUID- ORCID: 0000-0002-5764-2958
AD  - Department of Biomedical Engineering, The Chinese University of Hong Kong, 
      Shatin, New Territories, 999077 Hong Kong, P. R. China.
FAU - Lee, Wayne Yuk Wai
AU  - Lee WYW
AD  - Department of Orthopedic and Traumatology, Faculty of Medicine, The Chinese 
      University of Hong Kong, Shatin, New Territories, 999077 Hong Kong, P. R. China.
FAU - Ke, Ya
AU  - Ke Y
AD  - School of Biomedical Sciences, Faculty of Medicine, The Chinese University of 
      Hong Kong, Shatin, New Territories, 999077 Hong Kong, P. R. China.
FAU - Yung, Wing Ho
AU  - Yung WH
AD  - School of Biomedical Sciences, Faculty of Medicine, The Chinese University of 
      Hong Kong, Shatin, New Territories, 999077 Hong Kong, P. R. China.
FAU - Tang, Ben Zhong
AU  - Tang BZ
AUID- ORCID: 0000-0002-0293-964X
AD  - Hong Kong Branch of Chinese National Engineering Research Center for Tissue 
      Restoration and Reconstruction, Department of Chemistry, The Hong Kong University 
      of Science and Technology, Clear Water Bay, Kowloon, 999077 Hong Kong, P. R. 
      China.
FAU - Bian, Liming
AU  - Bian L
AUID- ORCID: 0000-0003-4739-0918
AD  - Department of Biomedical Engineering, The Chinese University of Hong Kong, 
      Shatin, New Territories, 999077 Hong Kong, P. R. China.
AD  - The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen 518000, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20210308
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Peptides)
RN  - 0 (RNA, Small Interfering)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Cell Line
MH  - Gene Transfer Techniques
MH  - Humans
MH  - Matrix Metalloproteinase 3/analysis/genetics
MH  - Molecular Imaging
MH  - Parkinson Disease/*diagnostic imaging/genetics/*therapy
MH  - Peptides/*chemistry
MH  - RNA, Small Interfering/*administration & dosage/genetics/therapeutic use
MH  - *RNAi Therapeutics
OTO - NOTNLM
OT  - Parkinson's disease
OT  - aggregation-induced emission
OT  - biomarker-triggered nanoprobe
OT  - metalloproteinase 3
OT  - upconversion nanoparticles
EDAT- 2021/03/09 06:00
MHDA- 2021/07/21 06:00
CRDT- 2021/03/08 17:08
PHST- 2021/03/09 06:00 [pubmed]
PHST- 2021/07/21 06:00 [medline]
PHST- 2021/03/08 17:08 [entrez]
AID - 10.1021/acsami.0c22112 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2021 Mar 17;13(10):11609-11620. doi: 
      10.1021/acsami.0c22112. Epub 2021 Mar 8.