PMID- 33684336 OWN - NLM STAT- MEDLINE DCOM- 20210805 LR - 20210805 IS - 1944-0057 (Electronic) IS - 1944-0057 (Linking) VI - 38 IP - 5 DP - 2021 May TI - Development of an ultrasensitive spectrophotometric method for carmine determination based on fluorescent carbon dots. PG - 731-740 LID - 10.1080/19440049.2021.1889045 [doi] AB - A high-efficiency spectrophotometric method based on nitrogen-doped fluorescent carbon dots (N-FCDs) was developed for the ultrasensitive determination of carmine (CRM) in foodstuffs. The N-FCDs were fabricated via a one-pot hydrothermal method with m-phenylenediamine as the starting material. The detection principle was based on the fluorescence quenching effect of N-FCDs by CRM, where their interaction was due to the inner filter effect (IFE) and static quenching. A good linear relationship was established for CRM detection in a concentration range of 0.1-10.0 muM with a detection limit as low as 11.2 nM. The proposed method achieved satisfactory results for CRM determination in commercial food products with recoveries better than 98.6% and relative standard deviations (RSDs) less than 4.07%. The method established in this study was simple, ultrasensitive and reliable for rapid detecting CRM in a food matrix, which could be potentially used as a useful sensing agent for the analysis of additive food colourants. FAU - Hu, Qin AU - Hu Q AD - College of Food Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225001, PR China. AD - Jiangsu Key Laboratory of Dairy Biotechnology and Safety Control, Yangzhou University, Yangzhou 225127, Jiangsu, China. FAU - Sun, Huijuan AU - Sun H AD - College of Food Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225001, PR China. AD - Jiangsu Key Laboratory of Dairy Biotechnology and Safety Control, Yangzhou University, Yangzhou 225127, Jiangsu, China. FAU - Liu, Lingfei AU - Liu L AD - College of Food Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225001, PR China. AD - Jiangsu Key Laboratory of Dairy Biotechnology and Safety Control, Yangzhou University, Yangzhou 225127, Jiangsu, China. FAU - Xiao, Lixia AU - Xiao L AD - College of Food Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225001, PR China. AD - Jiangsu Key Laboratory of Dairy Biotechnology and Safety Control, Yangzhou University, Yangzhou 225127, Jiangsu, China. FAU - Yang, Zhen-Quan AU - Yang ZQ AD - College of Food Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225001, PR China. AD - Jiangsu Key Laboratory of Dairy Biotechnology and Safety Control, Yangzhou University, Yangzhou 225127, Jiangsu, China. FAU - Rao, Shengqi AU - Rao S AD - College of Food Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225001, PR China. AD - Jiangsu Key Laboratory of Dairy Biotechnology and Safety Control, Yangzhou University, Yangzhou 225127, Jiangsu, China. FAU - Gong, Xiaojuan AU - Gong X AD - Institute of Environmental Science, and School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, PR China. FAU - Han, Jie AU - Han J AD - School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225001, PR China. LA - eng PT - Journal Article DEP - 20210308 PL - England TA - Food Addit Contam Part A Chem Anal Control Expo Risk Assess JT - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment JID - 101485040 RN - 0 (Fluorescent Dyes) RN - 7440-44-0 (Carbon) RN - CID8Z8N95N (Carmine) SB - IM MH - Carbon/*chemistry MH - Carmine/*analysis MH - Fluorescent Dyes/*chemistry MH - *Food Analysis MH - Food Contamination/*analysis MH - Quantum Dots/*chemistry MH - Spectrometry, Fluorescence OTO - NOTNLM OT - Carmine OT - N-doped carbon dots OT - inner filter effect OT - spectrophotometric method EDAT- 2021/03/09 06:00 MHDA- 2021/08/06 06:00 CRDT- 2021/03/08 20:10 PHST- 2021/03/09 06:00 [pubmed] PHST- 2021/08/06 06:00 [medline] PHST- 2021/03/08 20:10 [entrez] AID - 10.1080/19440049.2021.1889045 [doi] PST - ppublish SO - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 May;38(5):731-740. doi: 10.1080/19440049.2021.1889045. Epub 2021 Mar 8.