PMID- 33684464
OWN - NLM
STAT- MEDLINE
DCOM- 20210527
LR  - 20210527
IS  - 1879-176X (Electronic)
IS  - 0300-5712 (Linking)
VI  - 108
DP  - 2021 May
TI  - Changes in saliva characteristics and carious status related to metabolic control 
      in patients with type 2 diabetes mellitus.
PG  - 103629
LID - S0300-5712(21)00050-6 [pii]
LID - 10.1016/j.jdent.2021.103629 [doi]
AB  - OBJECTIVES: This cross-sectional study aimed: 1) to compare the saliva 
      characteristics and the occurrence of caries in patients with type 2 diabetes 
      mellitus (T2DM) and patients without T2DM, 2) to study the impact of inadequate 
      glycemic control on saliva and caries prevalence. METHODS: 23 adults with T2DM 
      and 18 controls participated. Patients with T2DM were divided depending on their 
      metabolic control: a) well-controlled (W.C.): HbA1c</=7 %, and b) poorly-controlled 
      (P.C.): HbA1c> 7 %). The examined clinical parameters were: 1) number of natural 
      teeth, 2) DMFT index of coronal caries, 3) saliva pH, 4) saliva flow and 
      buffering capacity, and 5) subjective feeling of dry mouth. RESULTS: The groups 
      W.C and P.C showed significant differences in the number of teeth, the saliva 
      flow, and DMFT. The C and P.C groups presented differences in pH, saliva flow, 
      buffer capacity, and DMFT. Finally, the W.C and C groups indicated differences in 
      the buffer capacity, saliva flow, and DMFT. The subjective feeling of dry mouth 
      is related to the duration of the disease. The DMFT value correlated negatively 
      with the status of metabolic regulation. Multiple linear regression revealed that 
      the DMFT value was positively associated with serum HbA1c levels. CONCLUSIONS: 1) 
      Adults with T2DM present a lower saliva flow rate and buffering capacity, as well 
      as higher caries prevalence than controls; 2) The metabolic control of T2DM is 
      essential for the maintenance of saliva flow rate and buffering capacity, and 
      caries prevalence; 3) The duration of T2DM is of importance for the subjective 
      sense of dry mouth. CLINICAL SIGNIFICANCE: The duration and metabolic control of 
      T2DM are important clinical parameters for oral complications. Awareness and 
      co-operation of diabetologists and dentists are needed to detect oral lesions in 
      patients with diabetes and be treated timely and effectively.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Rahiotis, Christos
AU  - Rahiotis C
AD  - School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 
      Goudi, 11527, Greece. Electronic address: craxioti@dent.uoa.gr.
FAU - Petraki, Vasilia
AU  - Petraki V
AD  - School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 
      Goudi, 11527, Greece.
FAU - Mitrou, Panagiota
AU  - Mitrou P
AD  - Ministry of Health, Aristotelous 17, Athens, 10433, Greece.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210305
PL  - England
TA  - J Dent
JT  - Journal of dentistry
JID - 0354422
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - DMF Index
MH  - *Dental Caries/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - Saliva
MH  - *Xerostomia/epidemiology/etiology
OTO - NOTNLM
OT  - Buffer capacity
OT  - Caries
OT  - ICDAS
OT  - Saliva flow
OT  - Type 2 diabetes mellitus
OT  - Xerostomia
EDAT- 2021/03/09 06:00
MHDA- 2021/05/28 06:00
CRDT- 2021/03/08 20:10
PHST- 2021/01/21 00:00 [received]
PHST- 2021/02/26 00:00 [revised]
PHST- 2021/03/02 00:00 [accepted]
PHST- 2021/03/09 06:00 [pubmed]
PHST- 2021/05/28 06:00 [medline]
PHST- 2021/03/08 20:10 [entrez]
AID - S0300-5712(21)00050-6 [pii]
AID - 10.1016/j.jdent.2021.103629 [doi]
PST - ppublish
SO  - J Dent. 2021 May;108:103629. doi: 10.1016/j.jdent.2021.103629. Epub 2021 Mar 5.