PMID- 33684644
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20211129
IS  - 1898-4002 (Electronic)
IS  - 1896-1126 (Linking)
VI  - 66
IP  - 1
DP  - 2021 Mar
TI  - Profile of new vascular damage biomarkers in middle-aged men with arterial 
      hypertension.
PG  - 185-191
LID - S1896-1126(21)00012-2 [pii]
LID - 10.1016/j.advms.2021.02.004 [doi]
AB  - PURPOSE: Normal endothelial function is important for the homeostasis of the 
      cardiovascular (CV) system. The aim of the present study was to determine the 
      profile of key parameters of endothelial dysfunction in middle-aged men that play 
      a significant role in the functioning of endothelial vessels, which seems to be 
      crucial for the early diagnosis of cardiovascular disorders. MATERIALS AND 
      METHODS: The study included 53 men, 20 with hypertension (HTN), 18 with HTN and 
      related diseases, 15 healthy controls Apart from general testing (BMI, 
      biochemical analysis, SBP, DBP), we used the Griess reaction to assess the total 
      amount of nitric oxide (NO), and used ELISA to verify the concentrations of 
      malondialdehyde (MDA), nitrotyrosine (NT), asymmetric dimethylarginine (ADMA), 
      tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein 1 (MCP-1), and 
      myeloperoxidase (MPO). Furthermore, we assessed the concentration of circulating 
      free DNA (cfDNA) using the fluorescence method. RESULTS: The values of MDA, ADMA, 
      cfDNA, and MPO observed in samples from men with HTN were determined to be higher 
      compared to those from men without HTN. In the group of men with HTN and other 
      concomitant cardiovascular disorders, we observed low concentrations of NO, MDA, 
      and ADMA with high concentrations of cfDNA. CONCLUSIONS: The results obtained for 
      parameters selected for the study, should be considered by cardiologists as a 
      prompt to include in the diagnostic profile the assessment of NO and cfDNA 
      concentrations for risk evaluation and/or diagnosis of endothelial dysfunction in 
      patients suffering from HTN or related complications.
CI  - Copyright (c) 2021 Medical University of Bialystok. Published by Elsevier B.V. All 
      rights reserved.
FAU - Charkiewicz, Angelika Edyta
AU  - Charkiewicz AE
AD  - Department of Public Health, Faculty of Health Sciences, Medical University of 
      Bialystok, Bialystok, Poland. Electronic address: angelika.charkiewicz@gmail.com.
FAU - Garley, Marzena
AU  - Garley M
AD  - Department of Immunology, Faculty of Pharmacy with the Division of Laboratory 
      Medicine, Medical University of Bialystok, Bialystok, Poland.
FAU - Ratajczak-Wrona, Wioletta
AU  - Ratajczak-Wrona W
AD  - Department of Immunology, Faculty of Pharmacy with the Division of Laboratory 
      Medicine, Medical University of Bialystok, Bialystok, Poland.
FAU - Nowak, Karolina
AU  - Nowak K
AD  - Department of Immunology, Faculty of Pharmacy with the Division of Laboratory 
      Medicine, Medical University of Bialystok, Bialystok, Poland.
FAU - Jablonska, Ewa
AU  - Jablonska E
AD  - Department of Immunology, Faculty of Pharmacy with the Division of Laboratory 
      Medicine, Medical University of Bialystok, Bialystok, Poland.
FAU - Maslach, Dominik
AU  - Maslach D
AD  - Department of Public Health, Faculty of Health Sciences, Medical University of 
      Bialystok, Bialystok, Poland.
FAU - Omeljaniuk, Wioleta Justyna
AU  - Omeljaniuk WJ
AD  - Department of Pharmaceutical Biochemistry, Faculty of Pharmacy with the Division 
      of Laboratory Medicine, Medical University of Bialystok, Bialystok, Poland. 
      Electronic address: wioleta.omeljaniuk@umb.edu.pl.
LA  - eng
PT  - Journal Article
DEP - 20210305
PL  - Netherlands
TA  - Adv Med Sci
JT  - Advances in medical sciences
JID - 101276222
RN  - 0 (Biomarkers)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Adult
MH  - Arginine/analogs & derivatives/metabolism
MH  - Biomarkers/*metabolism
MH  - Cardiovascular Diseases/metabolism/*pathology
MH  - Case-Control Studies
MH  - Endothelium, Vascular/metabolism/*pathology
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypertension/metabolism/*pathology
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Middle Aged
MH  - Nitric Oxide/metabolism
MH  - Prognosis
OTO - NOTNLM
OT  - Arterial hypertension
OT  - Endothelial dysfunction
OT  - Men
OT  - Neutrophil extracellular traps
OT  - Nitric oxide
EDAT- 2021/03/09 06:00
MHDA- 2021/11/30 06:00
CRDT- 2021/03/08 20:12
PHST- 2020/10/20 00:00 [received]
PHST- 2021/01/19 00:00 [revised]
PHST- 2021/02/21 00:00 [accepted]
PHST- 2021/03/09 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2021/03/08 20:12 [entrez]
AID - S1896-1126(21)00012-2 [pii]
AID - 10.1016/j.advms.2021.02.004 [doi]
PST - ppublish
SO  - Adv Med Sci. 2021 Mar;66(1):185-191. doi: 10.1016/j.advms.2021.02.004. Epub 2021 
      Mar 5.