PMID- 33684903
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20220118
LR  - 20220118
IS  - 1361-6528 (Electronic)
IS  - 0957-4484 (Linking)
VI  - 32
IP  - 25
DP  - 2021 Apr 1
TI  - NaYF(4):Yb/Tm@SiO(2)-Dox/Cur-CS/OSA nanoparticles with pH and photon responses.
LID - 10.1088/1361-6528/abecba [doi]
AB  - Stimulus-triggered drug delivery systems (DDSs) based on lanthanide-doped 
      upconversion nanoparticles (UCNPs) have attracted significant attention for 
      treating cancers due to their merits of high drug availability, precisely 
      controlled drug release, and low side-effects. However, such DDSs usually exhibit 
      a single stimulus-response, which may limit the efficiency of cancer treatment. 
      To extend response types in a single DDS, we construct 
      NaYF(4):Yb/Tm@SiO(2)-doxorubicin (Dox)/curcumin (Cur)-chitosan 
      (CS)/2-Octen-1-ylsuccinic anhydride (OSA) nanoparticles with core-shell 
      structures. Our method is based on the exploration of the synergistic effect of 
      UCNPs and multiple drugs. In particular, the NaYF(4):Yb/Tm is used to convert 
      near-infrared light to visible light, activating Cur photosensitizers to produce 
      singlet oxygen for photodynamic therapy, while CS/OSA responds to a low pH 
      environment to release cancer drugs, including Dox and Cur for chemotherapy 
      through breaking a free carboxyl group. The results show that the UCNPs with a 40 
      nm diameter, 23 nm thick mesoporous SiO(2), and 19/1 mol% 
      Yb(3+)/Tm(3+)concentrations could continuously release Dox and Cur at a pH value 
      of 6.5 within 6 h after the excitation of a 980 nm-wavelength CW laser. Our study 
      provides a promising approach for developing efficient DDSs for cancer treatment.
CI  - (c) 2021 IOP Publishing Ltd.
FAU - Qi, Xiaoling
AU  - Qi X
AD  - Department of Biomedical Engineering and Technology, Tianjin Medical University, 
      Tianjin 300070, People's Republic of China.
AD  - Department of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, People's Republic of China.
AD  - Key Laboratory of Opto-electronics Information Technology, Ministry of Education, 
      Tianjin 300072, People's Republic of China.
FAU - Han, Yingdong
AU  - Han Y
AD  - Department of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, People's Republic of China.
AD  - Key Laboratory of Opto-electronics Information Technology, Ministry of Education, 
      Tianjin 300072, People's Republic of China.
FAU - Liu, Shujing
AU  - Liu S
AD  - Department of Biomedical Engineering and Technology, Tianjin Medical University, 
      Tianjin 300070, People's Republic of China.
FAU - Hu, Haofeng
AU  - Hu H
AD  - Department of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, People's Republic of China.
AD  - Key Laboratory of Opto-electronics Information Technology, Ministry of Education, 
      Tianjin 300072, People's Republic of China.
FAU - Cheng, Zhenzhou
AU  - Cheng Z
AUID- ORCID: 0000-0003-4842-9458
AD  - Department of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, People's Republic of China.
AD  - Key Laboratory of Opto-electronics Information Technology, Ministry of Education, 
      Tianjin 300072, People's Republic of China.
FAU - Liu, Tiegen
AU  - Liu T
AD  - Department of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, People's Republic of China.
AD  - Key Laboratory of Opto-electronics Information Technology, Ministry of Education, 
      Tianjin 300072, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210401
PL  - England
TA  - Nanotechnology
JT  - Nanotechnology
JID - 101241272
SB  - IM
OTO - NOTNLM
OT  - chemotherapy
OT  - drug delivery systems
OT  - photodynamic therapy
OT  - upconversion nanoparticles
EDAT- 2021/03/09 06:00
MHDA- 2021/03/09 06:01
CRDT- 2021/03/08 20:18
PHST- 2020/12/31 00:00 [received]
PHST- 2021/03/08 00:00 [accepted]
PHST- 2021/03/09 06:00 [pubmed]
PHST- 2021/03/09 06:01 [medline]
PHST- 2021/03/08 20:18 [entrez]
AID - 10.1088/1361-6528/abecba [doi]
PST - epublish
SO  - Nanotechnology. 2021 Apr 1;32(25). doi: 10.1088/1361-6528/abecba.