PMID- 33686950
OWN - NLM
STAT- MEDLINE
DCOM- 20210720
LR  - 20210720
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 6
DP  - 2021 Mar 3
TI  - A dynamic nomogram for predicting diabetic macular edema in type 2 diabetes 
      patients based on plasma cytokines.
PG  - 8369-8379
LID - 10.18632/aging.202647 [doi]
AB  - OBJECTIVE: This study investigated changes of plasma cytokines and aimed to build 
      a dynamic nomogram for diabetic macular edema (DME) in type 2 diabetes mellitus 
      (T2DM). METHODS: In a pilot cohort, plasma samples were selected from 9 T2DM 
      patients and 9 DME patients to screen for cytokine differences. The screening 
      cytokines were then validated by enzyme-linked immunoassay in a cohort, which 
      contained 100 DME (DME group) and 100 T2DM patients without DME (T2DM group). A 
      dynamic nomogram for predicting DME was developed, based on the plasma cytokines. 
      RESULTS: In the pilot cohort, 11 plasma cytokines were significantly increased in 
      the DME group. In the validation cohort, platelet-derived growth factor 
      (PDGF)-BB, tissue inhibitors of metalloproteinase (TIMP)-1, angiopoietin (ANG-1), 
      and vascular endothelial cell growth factor receptor (VEGFR)-2 were confirmed to 
      be significantly elevated in the DME group. The dynamic nomogram demonstrated 
      good calibration and discrimination, with an area under the receiver operating 
      characteristic curve (AUC) of 0.88. In the test set, sensitivity, specificity, 
      and AUC were 73.3%, 80.0%, and 0.84, respectively. CONCLUSION: Plasma cytokines 
      were closely associated with DME. A novel dynamic monogram including ANG-1, 
      PDGF-BB, TIMP-1, and VEGFR2 was a novel tool for predicting DME.
FAU - Zhang, Ning
AU  - Zhang N
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101149, China.
AD  - Beijing Key Laboratory of Diabetes Research and Care, Beijing 101149, China.
FAU - Ke, Jing
AU  - Ke J
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101149, China.
AD  - Beijing Key Laboratory of Diabetes Research and Care, Beijing 101149, China.
FAU - Zhang, Dawei
AU  - Zhang D
AD  - Department of Ophthalmology, Beijing Luhe Hospital, Capital Medical University, 
      Beijing 101149, China.
FAU - Zhang, Yuanyuan
AU  - Zhang Y
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101149, China.
AD  - Beijing Key Laboratory of Diabetes Research and Care, Beijing 101149, China.
FAU - Fu, Ying
AU  - Fu Y
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101149, China.
AD  - Beijing Key Laboratory of Diabetes Research and Care, Beijing 101149, China.
FAU - Cao, Bin
AU  - Cao B
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101149, China.
AD  - Beijing Key Laboratory of Diabetes Research and Care, Beijing 101149, China.
FAU - Zhao, Dong
AU  - Zhao D
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101149, China.
AD  - Beijing Key Laboratory of Diabetes Research and Care, Beijing 101149, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210303
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - Cohort Studies
MH  - Cytokines/*blood
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Macular Edema/*blood/*etiology
MH  - Male
MH  - Middle Aged
MH  - Nomograms
MH  - Pilot Projects
PMC - PMC8034887
OTO - NOTNLM
OT  - diabetic macular edema
OT  - dynamic nomogram
OT  - plasma cytokines
OT  - type 2 diabetes mellitus
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interest.
EDAT- 2021/03/10 06:00
MHDA- 2021/07/21 06:00
PMCR- 2021/03/31
CRDT- 2021/03/09 08:39
PHST- 2020/11/13 00:00 [received]
PHST- 2021/01/22 00:00 [accepted]
PHST- 2021/03/10 06:00 [pubmed]
PHST- 2021/07/21 06:00 [medline]
PHST- 2021/03/09 08:39 [entrez]
PHST- 2021/03/31 00:00 [pmc-release]
AID - 202647 [pii]
AID - 10.18632/aging.202647 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 Mar 3;13(6):8369-8379. doi: 10.18632/aging.202647. Epub 
      2021 Mar 3.