PMID- 33687587 OWN - NLM STAT- MEDLINE DCOM- 20211229 LR - 20220716 IS - 1573-7330 (Electronic) IS - 1058-0468 (Print) IS - 1058-0468 (Linking) VI - 38 IP - 7 DP - 2021 Jul TI - Association of CPT1A gene polymorphism with the risk of gestational diabetes mellitus: a case-control study. PG - 1861-1869 LID - 10.1007/s10815-021-02143-y [doi] AB - PURPOSE: Gestational diabetes mellitus (GDM) is a growing public health problem worldwide and its etiology remains unclear. The pathophysiology of GDM is similar to that of type 2 diabetes (T2DM) and insulin resistance (IR) is the main reason for the development of GDM. Carnitine palmitoyltransferase 1A (CPT1A) is a candidate gene for metabolic disorders; however, the association of the CPT1A gene and GDM has not yet been studied. We aimed to explore whether single-nucleotide polymorphisms (SNPs) of the CPT1A gene could influence the risk of GDM. METHODS: We examined 18 single-nucleotide polymorphisms (SNPs) in the CPT1A gene and the risk of GDM in a nested case-control study of 334 GDM patients and 334 controls. The controls who had no GDM were randomly selected through matching to cases by age and residence. RESULTS: After adjusting the family history of diabetes, pre-pregnancy body mass index, and multiple comparison correction, the CPT1A rs2846194 and rs2602814 were associated with reduced GDM risk while rs59506005 was associated with elevated GDM risk. Moreover, the GGAC haplotype in the CPT1A gene (rs17399246 rs1016873 rs11228450 rs10896396) was associated with a reduced risk of GDM. CONCLUSION: Our study provides evidence for an association between genetic polymorphisms in the CPT1A and the risk of GDM. CI - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Ren, Qingwen AU - Ren Q AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Guo, Mengzhu AU - Guo M AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Yang, Feifei AU - Yang F AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Han, Tianbi AU - Han T AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Du, Wenqiong AU - Du W AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Zhao, Feng AU - Zhao F AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Li, Jinbo AU - Li J AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Li, Wangjun AU - Li W AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Feng, Yongliang AU - Feng Y AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Wang, Suping AU - Wang S AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. FAU - Zhang, Yawei AU - Zhang Y AD - National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Wu, Weiwei AU - Wu W AUID- ORCID: 0000-0003-0756-9331 AD - Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. wuweiwei2008@sina.com. LA - eng GR - 81703314/National Natural Science Foundation of China/ GR - 2019L0439/Scientific and Technological Innovation Project of Higher Education Institutions in Shanxi Province/ PT - Journal Article DEP - 20210309 PL - Netherlands TA - J Assist Reprod Genet JT - Journal of assisted reproduction and genetics JID - 9206495 RN - EC 2.3.1.21 (CPT1A protein, human) RN - EC 2.3.1.21 (Carnitine O-Palmitoyltransferase) SB - IM MH - Adult MH - Body Mass Index MH - Carnitine O-Palmitoyltransferase/*genetics MH - Case-Control Studies MH - Diabetes, Gestational/*genetics MH - Female MH - Genetic Predisposition to Disease MH - Haplotypes MH - Humans MH - *Polymorphism, Single Nucleotide MH - Pregnancy PMC - PMC8324722 OTO - NOTNLM OT - Carnitine palmitoyltransferase 1A (CPT1A) OT - Gestational diabetes mellitus OT - Haplotype OT - Single-nucleotide polymorphism COIS- The authors declare no competing interests. EDAT- 2021/03/10 06:00 MHDA- 2021/12/30 06:00 PMCR- 2022/07/01 CRDT- 2021/03/09 12:13 PHST- 2020/11/17 00:00 [received] PHST- 2021/03/03 00:00 [accepted] PHST- 2021/03/10 06:00 [pubmed] PHST- 2021/12/30 06:00 [medline] PHST- 2021/03/09 12:13 [entrez] PHST- 2022/07/01 00:00 [pmc-release] AID - 10.1007/s10815-021-02143-y [pii] AID - 2143 [pii] AID - 10.1007/s10815-021-02143-y [doi] PST - ppublish SO - J Assist Reprod Genet. 2021 Jul;38(7):1861-1869. doi: 10.1007/s10815-021-02143-y. Epub 2021 Mar 9.