PMID- 33687663
OWN - NLM
STAT- MEDLINE
DCOM- 20210527
LR  - 20210527
IS  - 1179-2035 (Electronic)
IS  - 0112-1642 (Linking)
VI  - 51
IP  - 6
DP  - 2021 Jun
TI  - Flavonoid Containing Polyphenol Consumption and Recovery from Exercise-Induced 
      Muscle Damage: A Systematic Review and Meta-Analysis.
PG  - 1293-1316
LID - 10.1007/s40279-021-01440-x [doi]
AB  - BACKGROUND: Flavonoid polyphenols are bioactive phytochemicals found in fruits 
      and teas among other sources. It has been postulated that foods and supplements 
      containing flavonoid polyphenols may enhance recovery from exercise-induced 
      muscle damage (EIMD) through upregulation of cell signalling stress response 
      pathways, particularly the nuclear factor erythroid 2-related factor 2 (NRF2) 
      pathway. OBJECTIVES: This study aims to investigate the ability of polyphenol 
      treatments containing flavonoids to enhance recovery of skeletal muscle strength, 
      soreness and creatine kinase post EIMD. METHODS: Medline (Pubmed), Embase and 
      SPORTdiscus were searched from inception to August 2020 for randomised 
      placebo-controlled trials which assessed the impact of 6 or more days of 
      flavonoid containing polyphenol ingestion on skeletal muscle recovery in the 96-h 
      period following a single bout of EIMD. A total of 2983 studies were screened in 
      duplicate resulting in 26 studies included for analysis. All meta-analyses were 
      undertaken using a random-effects model. RESULTS: The pooled results of these 
      meta-analyses show flavonoid polyphenol treatments can enhance recovery of muscle 
      strength by 7.14% (95% CI [5.50-8.78], P < 0.00001) and reduce muscle soreness by 
      4.12% (95% CI [- 5.82 to - 2.41] P = 0.00001), no change in the recovery of 
      creatine kinase concentrations was observed. CONCLUSION: These results indicate 
      that ingestion of polyphenol treatments which contain flavonoids has significant 
      potential to improve recovery of muscular strength and reduce muscle soreness in 
      the 4-day period post EIMD. However, the characterisation of polyphenol dosage 
      and composition of study treatments should be prioritised in future research to 
      facilitate the development of specific guidelines for the inclusion of 
      flavonoid-rich foods in the diet of athletes and active individuals.
FAU - Carey, Conor C
AU  - Carey CC
AUID- ORCID: 0000-0001-7243-2847
AD  - Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional 
      Sciences, University College Cork, Cork, Ireland.
FAU - Lucey, Alice
AU  - Lucey A
AUID- ORCID: 0000-0002-0623-7151
AD  - Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional 
      Sciences, University College Cork, Cork, Ireland.
FAU - Doyle, Lorna
AU  - Doyle L
AUID- ORCID: 0000-0002-3693-250X
AD  - Department of Sport and Exercise Science, Waterford Institute of Technology, 
      Waterford, Ireland. lmdoyle@wit.ie.
LA  - eng
GR  - 17F277 (2018 -2022)./Food Institutional Research Measure/
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210309
PL  - New Zealand
TA  - Sports Med
JT  - Sports medicine (Auckland, N.Z.)
JID - 8412297
RN  - 0 (Flavonoids)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Dietary Supplements
MH  - Exercise
MH  - *Flavonoids
MH  - Humans
MH  - Muscle, Skeletal
MH  - Myalgia
MH  - *Polyphenols
EDAT- 2021/03/10 06:00
MHDA- 2021/05/28 06:00
CRDT- 2021/03/09 12:15
PHST- 2021/02/20 00:00 [accepted]
PHST- 2021/03/10 06:00 [pubmed]
PHST- 2021/05/28 06:00 [medline]
PHST- 2021/03/09 12:15 [entrez]
AID - 10.1007/s40279-021-01440-x [pii]
AID - 10.1007/s40279-021-01440-x [doi]
PST - ppublish
SO  - Sports Med. 2021 Jun;51(6):1293-1316. doi: 10.1007/s40279-021-01440-x. Epub 2021 
      Mar 9.