PMID- 33688367
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210312
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2021
DP  - 2021
TI  - Evaluation of Beneficial and Adverse Effects of a Diet Supplemented with 
      Schisandrae Fructus Seed Ethanol Extract on Lipid and Glucose Metabolism in 
      Normal and Hypercholesterolemic/Hyperglycemic Mice.
PG  - 8858962
LID - 10.1155/2021/8858962 [doi]
LID - 8858962
AB  - Schisandrae Fructus (SF), the fruit of Schisandra chinensis (Turcz.) Baillon, has 
      been used for the treatment of liver injury and metabolism-related disorders in 
      China. The objective of this study was to investigate the effects of 
      supplementation with ethanol extract of SF seed (EtSF-S) on serum/hepatic lipid 
      and glucose levels as well as fecal total cholesterol (TC) contents in mice fed a 
      normal diet (ND) or high-fat/fructose diet (HFFD) containing 15% lard oil and 15% 
      fructose. Female ICR mice (18-20 g in body weight) were fed with ND or HFFD for 3 
      months, and then EtSF-S was added to both chow diets at increasing concentrations 
      of 1, 5, and 10% (w/w). Thirty days later, serum and hepatic lipids, including 
      TC, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein 
      (LDL), and glucose, were measured. Dietary supplementation with EtSF-S reduced 
      hepatic TC (36 and 18%) and TG levels (38 and 28%) and increased serum HDL/LDL 
      ratio (16 and 26%) in both ND- and HFFD-fed mice, respectively. Moreover, 
      supplementation with EtSF-S elevated serum HDL (31%) in HFFD-fed mice and reduced 
      serum LDL (27%) in ND-fed mice. EtSF-S treatment reduced fat mass (40%) in ND-fed 
      mice and increased fecal TC contents (33%) in HFFD-fed mice. EtSF-S 
      supplementation decreased hepatic glucose contents (29%) in both ND- and HFFD-fed 
      mice. However, diet supplemented with EtSF-S elevated serum TG levels (up to 
      123%) and hepatic size (28%), but more importantly, suppressed the body weight 
      gain (approximately 130%) in mice fed with HFFD. These findings suggested that 
      dietary supplementation with EtSF-S as natural herbal function food may be a 
      useful strategy for the treatment of patients with fatty liver disease or 
      overweight without a high intake of sugar and fat.
CI  - Copyright (c) 2021 Xiao-Yan Wang et al.
FAU - Wang, Xiao-Yan
AU  - Wang XY
AD  - The First Affiliated Hospital of Henan University of Traditional Chinese 
      Medicine, Zhengzhou, China.
FAU - Song, Xue-Lan
AU  - Song XL
AD  - School of Traditional Dai-Thai, West Yunnan University of Applied Sciences, 
      Jinghong, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - School of Chinese Materia Medica, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Luo, Gan
AU  - Luo G
AD  - School of Chinese Materia Medica, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Tai, Hai-Chuan
AU  - Tai HC
AD  - School of Traditional Dai-Thai, West Yunnan University of Applied Sciences, 
      Jinghong, China.
FAU - Lin, Zhao-Heng
AU  - Lin ZH
AD  - School of Traditional Dai-Thai, West Yunnan University of Applied Sciences, 
      Jinghong, China.
FAU - Zhu, Pei-Li
AU  - Zhu PL
AD  - School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
FAU - Sun, Nan
AU  - Sun N
AD  - School of Chinese Materia Medica, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Chu, Zhu-Sheng
AU  - Chu ZS
AD  - School of Chinese Materia Medica, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Yu, Zhi-Ling
AU  - Yu ZL
AD  - School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
FAU - Pan, Si-Yuan
AU  - Pan SY
AUID- ORCID: 0000-0002-4842-9629
AD  - School of Traditional Dai-Thai, West Yunnan University of Applied Sciences, 
      Jinghong, China.
AD  - School of Chinese Materia Medica, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Tang, Jin-Fa
AU  - Tang JF
AUID- ORCID: 0000-0001-7786-0955
AD  - The First Affiliated Hospital of Henan University of Traditional Chinese 
      Medicine, Zhengzhou, China.
FAU - Ko, Kam-Ming
AU  - Ko KM
AD  - Division of Life Science, Hong Kong University of Science & Technology, Hong 
      Kong, China.
LA  - eng
PT  - Journal Article
DEP - 20210220
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC7920717
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/03/11 06:00
MHDA- 2021/03/11 06:01
PMCR- 2021/02/20
CRDT- 2021/03/10 08:19
PHST- 2020/08/18 00:00 [received]
PHST- 2020/12/01 00:00 [revised]
PHST- 2021/01/21 00:00 [accepted]
PHST- 2021/03/10 08:19 [entrez]
PHST- 2021/03/11 06:00 [pubmed]
PHST- 2021/03/11 06:01 [medline]
PHST- 2021/02/20 00:00 [pmc-release]
AID - 10.1155/2021/8858962 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2021 Feb 20;2021:8858962. doi: 
      10.1155/2021/8858962. eCollection 2021.