PMID- 33688810
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 25
IP  - 3
DP  - 2021 Mar 1
TI  - Minimal clinically important difference of the 6-min walking test in patients 
      with asthma.
PG  - 215-221
LID - 10.5588/ijtld.20.0928 [doi]
AB  - BACKGROUND: The 6-min walking test (6MWT) is responsive to physiological changes 
      and pulmonary rehabilitation (PR) in patients with asthma. The minimal clinically 
      important difference (MCID) has not been established yet.OBJECTIVE: To determine 
      the MCID of 6MWT in patients with asthma.METHODS: Using the perceived change in 
      walking ability and the modified Medical Research Council (mMRC) score as 
      anchors, receiver operating characteristic curves and quantile regression, we 
      evaluated 6MWT before and after PR in these patients. The St George Respiratory 
      Questionnaire (SGRQ), the COPD assessment test (CAT) and other outcome measures 
      were also assessed.RESULTS: Of 142 patients with asthma, 37 were enrolled. After 
      PR, 6MWT increased from 453.4 m +/- 88.8 to 493.0 m +/- 97.2 (P = 0.0001); other 
      outcome measures also increased. There was a slight correlation between baseline 
      6MWT and SGRQ, CAT and mMRC. No significant correlations were found between 
      post-PR changes in 6MWT and in other outcome measures. Comparing different 
      methods of assessment, the MCID ranged from 26 m to 27 m.CONCLUSION: The most 
      conservative estimate of the MCID of 6MWT after PR was 26 m in patients with 
      asthma. This estimate may be useful in clinical interpretation of data, 
      particularly in response to intervention studies.
FAU - Zampogna, E
AU  - Zampogna E
AD  - Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, 
      Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Tradate.
FAU - Ambrosino, N
AU  - Ambrosino N
AD  - Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, 
      IRCCS, Montescano.
FAU - Centis, R
AU  - Centis R
AD  - Respiratory Diseases Clinical Epidemiology Unit, Istituti Clinici Scientifici 
      Maugeri, IRCCS, Tradate.
FAU - Cherubino, F
AU  - Cherubino F
AD  - Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, 
      Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Tradate.
FAU - Migliori, G B
AU  - Migliori GB
AD  - Respiratory Diseases Clinical Epidemiology Unit, Istituti Clinici Scientifici 
      Maugeri, IRCCS, Tradate.
FAU - Pignatti, P
AU  - Pignatti P
AD  - Allergy and Immunology Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Pavia.
FAU - Lo Bello, G
AU  - Lo Bello G
AD  - Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, 
      Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Tradate.
FAU - Saderi, L
AU  - Saderi L
AD  - Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and 
      Experimental Medicine, University of Sassari, Sassari.
FAU - Sotgiu, G
AU  - Sotgiu G
AD  - Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and 
      Experimental Medicine, University of Sassari, Sassari.
FAU - Zappa, M
AU  - Zappa M
AD  - Department of Medicine and Surgery, Respiratory Diseases, University of Insubria, 
      Tradate, Varese-Como, Italy.
FAU - Spanevello, A
AU  - Spanevello A
AD  - Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, 
      Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Tradate, Department 
      of Medicine and Surgery, Respiratory Diseases, University of Insubria, Tradate, 
      Varese-Como, Italy.
FAU - Visca, D
AU  - Visca D
AD  - Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, 
      Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Tradate, Department 
      of Medicine and Surgery, Respiratory Diseases, University of Insubria, Tradate, 
      Varese-Como, Italy.
LA  - eng
PT  - Journal Article
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal 
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - *Asthma/diagnosis
MH  - Humans
MH  - Minimal Clinically Important Difference
MH  - *Pulmonary Disease, Chronic Obstructive
MH  - Walk Test
MH  - Walking
EDAT- 2021/03/11 06:00
MHDA- 2021/05/29 06:00
CRDT- 2021/03/10 12:16
PHST- 2021/03/10 12:16 [entrez]
PHST- 2021/03/11 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
AID - 10.5588/ijtld.20.0928 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2021 Mar 1;25(3):215-221. doi: 10.5588/ijtld.20.0928.