PMID- 33689496
OWN - NLM
STAT- MEDLINE
DCOM- 20221017
LR  - 20221017
IS  - 1942-7522 (Electronic)
IS  - 0145-5613 (Linking)
VI  - 101
IP  - 9
DP  - 2022 Nov
TI  - Predictive Value of Radiologic Central Compartment Atopic Disease for Identifying 
      Allergy and Asthma in Pediatric Patients.
PG  - 593-599
LID - 10.1177/0145561321997546 [doi]
AB  - INTRODUCTION: Central compartment atopic disease (CCAD) has recently been 
      suggested as a phenotype of chronic rhinosinusitis (CRS). This study aims to 
      investigate the prevalence of the radiologic CCAD phenotype in CRS within a 
      pediatric population and identify its ability to predict comorbid allergy and 
      asthma. METHODS: Computed tomography and endoscopic examination were conducted on 
      pediatric patients with CRS either with or without nasal polyps. Allergen 
      sensitization was determined with the multiple-allergen simultaneous test and 
      skin prick test. Serum total immunoglobulin E (IgE), peripheral blood eosinophil 
      percentage, and presence of asthma were also evaluated. RESULTS: A total of 82 
      pediatric patients were enrolled. Overall, 55 (67.1%) of the participants 
      demonstrated aeroallergen sensitization, and 31 (18.9%) of the 164 sides of 
      sinuses were radiologically defined to fit the CCAD phenotype. Patients having 
      CRS with the CCAD phenotype had a higher prevalence of aeroallergen sensitization 
      (87.1% vs 62.4%, P = .008), particularly house dust mite (74.2% vs 53.4%, P = 
      .035), and a higher incidence of asthma (16.1% vs 3.8%, P = .010). Additionally, 
      patients having CRS with the CCAD phenotype demonstrated a high serum total IgE 
      levels (51.6% vs 30.1%, P = .023) in comparison to patients having CRS without 
      CCAD. CONCLUSION: In pediatric CRS, the radiological CCAD phenotype was 
      associated with allergen sensitization and asthma. Furthermore, the CCAD 
      phenotype was associated with high serum total IgE levels, suggesting allergy 
      etiology should be considered with this type of pediatric patients with CRS.
FAU - Lee, Kijeong
AU  - Lee K
AUID- ORCID: 0000-0002-9799-662X
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea 
      University, Seoul, Korea.
FAU - Kim, Tae Hoon
AU  - Kim TH
AUID- ORCID: 0000-0001-8811-654X
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea 
      University, Seoul, Korea.
FAU - Lee, Sang Hag
AU  - Lee SH
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea 
      University, Seoul, Korea.
FAU - Kang, Chang Ho
AU  - Kang CH
AD  - Department of Radiology, Anam Hospital, Korea University College of Medicine, 
      Seoul, Korea.
FAU - Je, Bo-Kyung
AU  - Je BK
AD  - Department of Radiology, Ansan Hospital, Korea University College of Medicine, 
      Ansan, Korea.
FAU - Oh, Saelin
AU  - Oh S
AD  - Department of Radiology, Anam Hospital, Korea University College of Medicine, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20210309
PL  - United States
TA  - Ear Nose Throat J
JT  - Ear, nose, & throat journal
JID - 7701817
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - *Asthma/epidemiology
MH  - Child
MH  - Chronic Disease
MH  - Humans
MH  - *Hypersensitivity/complications
MH  - Immunoglobulin E
MH  - *Sinusitis/complications/diagnostic imaging/epidemiology
OTO - NOTNLM
OT  - allergy
OT  - central compartment atopic disease
OT  - chronic rhinosinusitis
OT  - computed tomography
OT  - pediatrics
EDAT- 2021/03/11 06:00
MHDA- 2022/10/18 06:00
CRDT- 2021/03/10 17:33
PHST- 2021/03/11 06:00 [pubmed]
PHST- 2022/10/18 06:00 [medline]
PHST- 2021/03/10 17:33 [entrez]
AID - 10.1177/0145561321997546 [doi]
PST - ppublish
SO  - Ear Nose Throat J. 2022 Nov;101(9):593-599. doi: 10.1177/0145561321997546. Epub 
      2021 Mar 9.