PMID- 33691435
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 10
IP  - 4
DP  - 2021 Apr
TI  - Effect of Teriparatide on pain relief, and quality of life in postmenopausal 
      females with osteoporotic vertebral compression fractures, a retrospective cohort 
      study.
PG  - 4000-4007
LID - 10.21037/apm-20-2333 [doi]
AB  - BACKGROUND: Osteoporotic vertebral compression fracture (OVCF) is a common 
      disease in elderly population, which could cause serious back pain and has a 
      substantial impact on patients' health-related quality of life (HRQoL). The aim 
      of this study was to identify the effect of Teriparatide as a conservative 
      treatment on reducing back pain, and improving quality of life for postmenopausal 
      women with osteoporotic vertebral fractures. METHODS: In a 12-month, 
      retrospective study, 112 postmenopausal women with OVCFs were assigned to 
      Teriparatide group (20 microg Teriparatide, subcutaneous, once daily, n=38) or 
      control group (500 mg calcium and 400-800 IU Vitamin D per day, oral 
      administration, n=74) according to patients' choices between January 2016 and 
      October 2018. Patient-reported outcomes scores including the visual analogue 
      score (VAS), Oswestry disability index (ODI), and short form 36 questionnaire 
      (SF-36) were assessed at baseline, the 3rd months, the 6th months and 1 year 
      after treatment. RESULTS: Treatments with Teriparatide or calcium plus vitamin D 
      supplements had significant effect on improvement of patients' back pain as well 
      as HRQoL, with significantly reduced VAS and ODI and increased SF-36 physical 
      component summary (PCS) and mental component summary (MCS) scores. At the 
      endpoint, Teriparatide showed better therapeutic effect, with greater reductions 
      in VAS and ODI and more increases in SF-36 PCS and MCS scores. However, more 
      adverse events (AEs) were found in Teriparatide group, but symptoms were 
      relatively mild and of short duration. CONCLUSIONS: In postmenopausal women with 
      OVCFs, the consequent persistent back pain and impaired HRQoL, treatment with 
      Teriparatide was associated with more profound therapeutic effects and more AEs 
      compared with calcium plus vitamin D supplements.
FAU - Chen, Zhipeng
AU  - Chen Z
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics 
      and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, China.
FAU - Lin, Wei
AU  - Lin W
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics 
      and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, China.
FAU - Zhao, Shengli
AU  - Zhao S
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics 
      and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, China.
FAU - Mo, Xiaoyi
AU  - Mo X
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics 
      and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, China.
FAU - Yuan, Weiquan
AU  - Yuan W
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics 
      and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, China.
FAU - Cheung, Wing Hoi
AU  - Cheung WH
AD  - Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The 
      Chinese University of Hong Kong, Hong Kong, China.
FAU - Fu, Dan
AU  - Fu D
AD  - Department of Orthopedic, Kiang Wu Hospital, Macau, China.
FAU - Chen, Bailing
AU  - Chen B
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China; Guangdong Provincial Key Laboratory of Orthopedics 
      and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20210301
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
RN  - 10T9CSU89I (Teriparatide)
SB  - IM
MH  - Aged
MH  - Female
MH  - *Fractures, Compression/drug therapy
MH  - Humans
MH  - Postmenopause
MH  - Quality of Life
MH  - Retrospective Studies
MH  - *Spinal Fractures/drug therapy
MH  - Teriparatide/therapeutic use
OTO - NOTNLM
OT  - Teriparatide
OT  - back pain
OT  - health-related quality of life (HRQoL)
OT  - postmenopausal osteoporosis
OT  - spinal fractures
EDAT- 2021/03/12 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/03/11 05:37
PHST- 2020/11/24 00:00 [received]
PHST- 2021/01/13 00:00 [accepted]
PHST- 2021/03/12 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/03/11 05:37 [entrez]
AID - apm-20-2333 [pii]
AID - 10.21037/apm-20-2333 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2021 Apr;10(4):4000-4007. doi: 10.21037/apm-20-2333. Epub 2021 
      Mar 1.