PMID- 33691584
OWN - NLM
STAT- MEDLINE
DCOM- 20220125
LR  - 20220311
IS  - 1551-4005 (Electronic)
IS  - 1538-4101 (Print)
IS  - 1551-4005 (Linking)
VI  - 20
IP  - 8
DP  - 2021 Apr
TI  - Regulation of DNA duplication by the mTOR signaling pathway.
PG  - 742-751
LID - 10.1080/15384101.2021.1897271 [doi]
AB  - Accurate and complete DNA replication and separation are essential for genetic 
      information inheritance and organism maintenance. Errors in DNA duplication are 
      the main source of genetic instability. Understanding DNA duplication regulation 
      is the key to elucidate the mechanisms and find treatment strategies for human 
      genetic disorders, especially cancer. The mechanistic target of rapamycin (mTOR) 
      is a central regulator of cell growth and proliferation by integrating and 
      processing extracellular and intracellular signals to monitor the well-being of 
      cell physiology. mTOR signaling dysregulation is associated with many human 
      diseases including cancer and diabetes. Emerging evidence has demonstrated that 
      mTOR signaling plays a key role in DNA duplication. We herein review the current 
      knowledge of mTOR signaling in the regulation of DNA replication origin 
      licensing, replication fork progression, and stabilization.
FAU - He, Zhengfu
AU  - He Z
AD  - Department of Thoracic Surgery, Sir Run Run Shaw Hospital, College of Medicine 
      Zhejiang University, Hangzhou, China.
FAU - Houghton, Peter J
AU  - Houghton PJ
AD  - The Greehey Children's Cancer Research Institute, the University of Texas Health 
      Science Center at San Antonio, San Antonio, Texas, USA.
FAU - Williams, Terence M
AU  - Williams TM
AUID- ORCID: 0000-0002-1020-0845
AD  - Department of Radiation Oncology, Beckman Research Institute, City of Hope 
      National Medical Center, Duarte, California, USA.
FAU - Shen, Changxian
AU  - Shen C
AD  - Department of Radiation Oncology, Beckman Research Institute, City of Hope 
      National Medical Center, Duarte, California, USA.
LA  - eng
GR  - R01 CA246553/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210310
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/physiology
MH  - DNA Replication/*physiology
MH  - Humans
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
PMC - PMC8098070
OTO - NOTNLM
OT  - DNA repair
OT  - cell cycle
OT  - mTOR; DNA replication origin licensing
OT  - replication fork progression
OT  - replication fork stabilization
COIS- The authors declare no competing interests.
EDAT- 2021/03/12 06:00
MHDA- 2022/01/27 06:00
PMCR- 2022/03/10
CRDT- 2021/03/11 05:43
PHST- 2021/03/12 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/03/11 05:43 [entrez]
PHST- 2022/03/10 00:00 [pmc-release]
AID - 1897271 [pii]
AID - 10.1080/15384101.2021.1897271 [doi]
PST - ppublish
SO  - Cell Cycle. 2021 Apr;20(8):742-751. doi: 10.1080/15384101.2021.1897271. Epub 2021 
      Mar 10.