PMID- 33691639
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20211004
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Mar 10
TI  - Effect of congenital heart disease on the recurrence of cough variant asthma in 
      children.
PG  - 130
LID - 10.1186/s12872-021-01940-8 [doi]
LID - 130
AB  - BACKGROUND: The research into the recurrence of cough variant asthma (CVA) in 
      congenital heart disease (CHD) are few in number. The purpose of this study is to 
      investigate the effect of CHD on the risk of the recurrence of CVA. METHODS: This 
      study was a retrospective cohort study of 489 children with CVA aged between one 
      and 14 years, of whom 67 had CHD complicated with CVA and 134 had CVA without CHD 
      at a ratio of 1:2 according to age, sex and index year. The adjusted hazard ratio 
      (aHR) of CVA recurrence in both the CHD cohort and the non-CHD cohort was 
      determined by multivariate analysis using the Cox proportional hazard regression 
      model. RESULTS: Adjusting for CHD classification, Mycoplasma pneumonia (MP) 
      infection and immunoglobulin E (IgE) sensitization, the recurrence hazard of CVA 
      in the complex congenital heart disease (CCHD) group (aHR = 3.281; 95% CI 
      1.648-6.530; P < 0.01) was significantly higher than that in the simple 
      congenital heart disease group (aHR = 2.555; 95% CI 1.739-3.752; P < 0.01). 
      Further, children with IgE sensitization (aHR = 2.172; 95% CI 1.482-3.184; 
      P < 0.01) had a higher recurrence hazard of CVA than those without IgE 
      sensitization, and children with MP infection (aHR = 1.777; 95% CI 1.188-2.657; 
      P < 0.01) had a higher recurrence hazard of CVA than those without the MP 
      infection. CONCLUSION: The hazard of recurrent CVA is higher in children with 
      CHD, especially in the CCHD children. In addition, those children with IgE 
      sensitization or a MP infection had an increased hazard of recurrent CVA.
FAU - Feng, B W
AU  - Feng BW
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
AD  - Department of Neonatology of Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, Guangdong, China.
FAU - He, C Y
AU  - He CY
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
AD  - Department of Neonatology of Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, Guangdong, China.
FAU - Liu, X Q
AU  - Liu XQ
AD  - Department of Epidemiology, Guangdong Provincial People's Hospital, Guangzhou, 
      Guangdong, China.
FAU - Chen, Y S
AU  - Chen YS
AD  - Department of Neonatology of Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, Guangdong, China.
FAU - He, S R
AU  - He SR
AUID- ORCID: 0000-0002-0229-4060
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China. heshaoru2020@163.com.
AD  - Department of Neonatology of Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, Guangdong, China. heshaoru2020@163.com.
AD  - Department of Pediatrics of Guangdong Provincial People's Hospital, 106 Zhongshan 
      Er Road, Guangzhou, 510080, Guangdong, China. heshaoru2020@163.com.
LA  - eng
GR  - 81671529/National Natural Foundation of China/
GR  - 2018YFC1002600/National key R &amp; D Program of China/
GR  - 2011BAI11B22/"twelve five" National Science and Technology Support Program/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210310
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Anti-Asthmatic Agents)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Anti-Asthmatic Agents/therapeutic use
MH  - Asthma/drug therapy/*etiology/immunology/microbiology
MH  - Child
MH  - Child, Preschool
MH  - Cough/drug therapy/*etiology/immunology/microbiology
MH  - Female
MH  - Heart Defects, Congenital/*complications
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Mycoplasma pneumoniae/pathogenicity
MH  - Pneumonia, Mycoplasma/complications/microbiology
MH  - Recurrence
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
PMC - PMC7949247
OTO - NOTNLM
OT  - CHD
OT  - CVA
OT  - Hazard of recurrent CVA
COIS- The authors declare that they have no competing interests.
EDAT- 2021/03/12 06:00
MHDA- 2021/10/05 06:00
PMCR- 2021/03/10
CRDT- 2021/03/11 05:45
PHST- 2020/10/23 00:00 [received]
PHST- 2021/03/01 00:00 [accepted]
PHST- 2021/03/11 05:45 [entrez]
PHST- 2021/03/12 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2021/03/10 00:00 [pmc-release]
AID - 10.1186/s12872-021-01940-8 [pii]
AID - 1940 [pii]
AID - 10.1186/s12872-021-01940-8 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2021 Mar 10;21(1):130. doi: 10.1186/s12872-021-01940-8.