PMID- 33693166
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210312
IS  - 2434-0790 (Electronic)
IS  - 2434-0790 (Linking)
VI  - 1
IP  - 9
DP  - 2019 Aug 28
TI  - Cardiac Function in Infants Born to Mothers With Gestational Diabetes　- 
      Estimation of Early Diastolic Intraventricular Pressure Differences.
PG  - 378-388
LID - 10.1253/circrep.CR-19-0062 [doi]
AB  - Background: This study compared the myocardial performance of infants born to 
      mothers with gestational diabetes mellitus (IGDM) and without GDM (controls) 
      under the new GDM definitions. Methods and Results: The subjects consisted of 36 
      IGDM and 39 control infants. GDM diagnosis was based on oral glucose tolerance 
      test during pregnancy or the presence of diabetes prior to the current pregnancy. 
      Between-group infant cardiac function was determined and compared using 2-D 
      speckle tracking analysis, intraventricular pressure difference (IVPD) and IVP 
      gradient (IVPG), using color M-mode Doppler imaging. IVPD and IVPG were higher in 
      IGDM than in the controls, particularly the mid-apical IVPG. The global 
      circumferential strain (GCS) and endocardial GCS were higher in IGDM than in 
      controls. Increased maternal glycated hemoglobin was correlated with reduced 
      transmural and epicardial GCS in the IGDM. Maternal maximum fasting blood sugar 
      had a mild, positive correlation with IVPD and IVPG. Conclusions: Ventricular 
      sucking force, measured as the IVPD, IVPG, and endocardial GCS, were higher in 
      IGDM than in the controls. A hyperglycemic environment during pregnancy leads to 
      impaired cardiac performance in IGDM, compared with control infants. IGDM might 
      have favorable systolic and diastolic cardiac performance due to cardiac 
      metabolic adaptations occurring before poor glucose control causes impaired 
      cardiac performance.
CI  - Copyright (c) 2019, THE JAPANESE CIRCULATION SOCIETY.
FAU - Iwashima, Satoru
AU  - Iwashima S
AD  - Department of Pediatric Cardiology, Chutoen General Medical Center Kakegawa 
      Japan.
FAU - Hayano, Satoshi
AU  - Hayano S
AD  - Department of Pediatric Cardiology, Chutoen General Medical Center Kakegawa 
      Japan.
FAU - Murakami, Yusuke
AU  - Murakami Y
AD  - Department of Obstetrics and Gynecology, Chutoen General Medical Center Kakegawa 
      Japan.
FAU - Tanaka, Aki
AU  - Tanaka A
AD  - Department of Obstetrics and Gynecology, Chutoen General Medical Center Kakegawa 
      Japan.
FAU - Joko, Yumiko
AU  - Joko Y
AD  - Department of Cardiology, Chutoen General Medical Center Kakegawa Japan.
FAU - Morikawa, Shuji
AU  - Morikawa S
AD  - Department of Cardiology, Chutoen General Medical Center Kakegawa Japan.
FAU - Ifuku, Mayumi
AU  - Ifuku M
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine Tokyo Japan.
FAU - Iso, Takeshi
AU  - Iso T
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine Tokyo Japan.
FAU - Takahashi, Ken
AU  - Takahashi K
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine Tokyo Japan.
LA  - eng
PT  - Journal Article
DEP - 20190828
PL  - Japan
TA  - Circ Rep
JT  - Circulation reports
JID - 101746642
PMC - PMC7892812
OTO - NOTNLM
OT  - Color M-mode Doppler imaging
OT  - Diabetic cardiomyopathy
OT  - Infant with gestational diabetes mother
OT  - Intraventricular pressure difference
COIS- There are no conflicts of interest to declare. This research received no specific 
      grant from any funding agency in the public, commercial, or not-for profit 
      sectors. Equipment of the Chutoen General Medical Center was used.
EDAT- 2019/08/28 00:00
MHDA- 2019/08/28 00:01
PMCR- 2019/08/28
CRDT- 2021/03/11 06:39
PHST- 2021/03/11 06:39 [entrez]
PHST- 2019/08/28 00:00 [pubmed]
PHST- 2019/08/28 00:01 [medline]
PHST- 2019/08/28 00:00 [pmc-release]
AID - 10.1253/circrep.CR-19-0062 [doi]
PST - epublish
SO  - Circ Rep. 2019 Aug 28;1(9):378-388. doi: 10.1253/circrep.CR-19-0062.