PMID- 33694028
OWN - NLM
STAT- MEDLINE
DCOM- 20210727
LR  - 20220301
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 25
IP  - 7
DP  - 2021 Jul
TI  - Bone quality analysis of jaw bones in individuals with type 2 diabetes 
      mellitus-post mortem anatomical and microstructural evaluation.
PG  - 4377-4400
LID - 10.1007/s00784-020-03751-1 [doi]
AB  - OBJECTIVES: With the higher risk of dental implant failure with type 2 diabetes 
      mellitus (T2DM), there is a need to characterize the jaw bones in those 
      individuals. The aim of this post mortem study was to compare jaw bone quality of 
      individuals with T2DM to healthy controls. MATERIAL AND METHODS: Bone cores from 
      the edentulous lower first molar region and the region of mandibular angle were 
      collected from male individuals with T2DM (n = 10, 70.6 +/- 4.5 years) and healthy 
      controls (n = 11, 71.5 +/- 3.8 years) during autopsy. Within the T2DM, a subgroup 
      treated with oral antidiabetics (OAD) and one on insulin were identified. Bone 
      quality assessment encompassed evaluation of bone microstructure, matrix 
      composition, and cellular activity, using microcomputed tomography (micro-CT), 
      quantitative backscattered electron imaging (qBEI), Raman spectroscopy, and bone 
      histomorphometry. RESULTS: In the mandibular angle, T2DM showed 51% lower 
      porosity of the lingual cortex (p = 0.004) and 21% higher trabecular thickness 
      (p = 0.008) compared to control. More highly mineralized bone packets were found 
      in the buccal cortex of the mandibular angle in insulin-treated compared to 
      OAD-treated T2DM group (p = 0.034). In the molar region, we found higher 
      heterogeneity of trabecular calcium content in T2DM insulin compared to controls 
      (p = 0.015) and T2DM OAD (p = 0.019). T2DM was associated with lower osteocyte 
      lacunar size in the trabecular bone of the molar region (vs. control p = 0.03). 
      CONCLUSIONS: Alterations in microstructure, mineralization, and osteocyte 
      morphology were determined in jaw bone of individuals with T2DM compared to 
      controls. CLINICAL RELEVANCE: Future studies will have to verify if the mild 
      changes determined in this study will translate to potential contraindications 
      for dental implant placements.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part 
      of Springer Nature.
FAU - Rodic, Teodora
AU  - Rodic T
AD  - Laboratory for Anthropology and Skeletal Biology, Institute for Anatomy, School 
      of Medicine, University of Belgrade, Dr Subotica starijeg 4, Belgrade, 11000, 
      Serbia.
FAU - Wolfel, Eva Maria
AU  - Wolfel EM
AD  - Institute for Osteology and Biomechanics, University Medical Center Hamburg- 
      Eppendorf, Lottestrasse 55, 22529, Hamburg, Germany.
FAU - Milovanovic, Petar
AU  - Milovanovic P
AD  - Laboratory for Anthropology and Skeletal Biology, Institute for Anatomy, School 
      of Medicine, University of Belgrade, Dr Subotica starijeg 4, Belgrade, 11000, 
      Serbia.
AD  - Institute for Osteology and Biomechanics, University Medical Center Hamburg- 
      Eppendorf, Lottestrasse 55, 22529, Hamburg, Germany.
FAU - Fiedler, Imke A K
AU  - Fiedler IAK
AD  - Institute for Osteology and Biomechanics, University Medical Center Hamburg- 
      Eppendorf, Lottestrasse 55, 22529, Hamburg, Germany.
FAU - Cvetkovic, Danica
AU  - Cvetkovic D
AD  - Institute for Forensic Medicine, School of Medicine, University of Belgrade, 
      Deligradska 31/A, Belgrade, 11000, Serbia.
FAU - Jahn, Katharina
AU  - Jahn K
AD  - Institute for Osteology and Biomechanics, University Medical Center Hamburg- 
      Eppendorf, Lottestrasse 55, 22529, Hamburg, Germany.
FAU - Amling, Michael
AU  - Amling M
AD  - Institute for Osteology and Biomechanics, University Medical Center Hamburg- 
      Eppendorf, Lottestrasse 55, 22529, Hamburg, Germany.
FAU - Sopta, Jelena
AU  - Sopta J
AD  - Institute for Pathology, School of Medicine, University of Belgrade, Dr Subotica 
      starijeg 1, Belgrade, 11000, Serbia.
FAU - Nikolic, Slobodan
AU  - Nikolic S
AD  - Institute for Forensic Medicine, School of Medicine, University of Belgrade, 
      Deligradska 31/A, Belgrade, 11000, Serbia.
FAU - Zivkovic, Vladimir
AU  - Zivkovic V
AD  - Institute for Forensic Medicine, School of Medicine, University of Belgrade, 
      Deligradska 31/A, Belgrade, 11000, Serbia.
FAU - Busse, Bjorn
AU  - Busse B
AD  - Institute for Osteology and Biomechanics, University Medical Center Hamburg- 
      Eppendorf, Lottestrasse 55, 22529, Hamburg, Germany.
FAU - Djuric, Marija
AU  - Djuric M
AUID- ORCID: 0000-0001-6267-827X
AD  - Laboratory for Anthropology and Skeletal Biology, Institute for Anatomy, School 
      of Medicine, University of Belgrade, Dr Subotica starijeg 4, Belgrade, 11000, 
      Serbia. marijadjuric5@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210311
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
MH  - Autopsy
MH  - Bone Density
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - Male
MH  - Mandible/diagnostic imaging
MH  - X-Ray Microtomography
OTO - NOTNLM
OT  - Bone
OT  - Jaw
OT  - Microstructure
OT  - Mineralization
OT  - Osteocytes
OT  - Type 2 diabetes mellitus
EDAT- 2021/03/12 06:00
MHDA- 2021/07/28 06:00
CRDT- 2021/03/11 07:08
PHST- 2020/05/26 00:00 [received]
PHST- 2020/12/18 00:00 [accepted]
PHST- 2021/03/12 06:00 [pubmed]
PHST- 2021/07/28 06:00 [medline]
PHST- 2021/03/11 07:08 [entrez]
AID - 10.1007/s00784-020-03751-1 [pii]
AID - 10.1007/s00784-020-03751-1 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2021 Jul;25(7):4377-4400. doi: 10.1007/s00784-020-03751-1. 
      Epub 2021 Mar 11.