PMID- 33694168
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20211129
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 236
IP  - 10
DP  - 2021 Oct
TI  - The region-selective regulation of endothelial claudin-5 expression and signaling 
      in brain health and disorders.
PG  - 7134-7143
LID - 10.1002/jcp.30357 [doi]
AB  - The neurovascular unit (NVU) consists of neurons, glial cells, microvascular 
      cells, and extracellular matrix, and is involved in a variety of physiological 
      and pathological processes in the central nervous system (CNS). Within the NVU, 
      the microvascular endothelial cells and pericytes principally contribute to 
      maintaining the integrity of the blood-brain barrier (BBB). Various types of 
      cells are connected to each other in the NVU by diverse cell adhesion molecules, 
      of which claudin-5 (CLDN5) is by far the most abundantly expressed tight-junction 
      protein in brain microvascular endothelial cells and absolutely required for the 
      maintenance of the BBB. This review highlights recent progress in understanding 
      the region-specific regulation and dysregulation of CLDN5 expression in CNS 
      health and disorders. We also discuss how CLDN5 expression is regionally 
      disrupted within the NVU. In addition, we focus on the link between cell adhesion 
      and transcription factor signalings and describe the possible involvement of 
      CLDN5-adhesion signaling in brain health and disorders.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Chiba, Hideki
AU  - Chiba H
AUID- ORCID: 0000-0003-1777-8460
AD  - Department of Basic Pathology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Ichikawa-Tomikawa, Naoki
AU  - Ichikawa-Tomikawa N
AD  - Department of Basic Pathology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Imura, Tetsuya
AU  - Imura T
AD  - Department of Basic Pathology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
AD  - Department of Surgical Pathology, Kyoto Prefectural University of Medicine, 
      Kyoto, Japan.
FAU - Sugimoto, Kotaro
AU  - Sugimoto K
AUID- ORCID: 0000-0002-5299-7610
AD  - Department of Basic Pathology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210310
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Claudin-5)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*metabolism/pathology
MH  - Brain Diseases/genetics/*metabolism/pathology
MH  - Claudin-5/genetics/*metabolism
MH  - Endothelial Cells/*metabolism/pathology
MH  - Gene Expression Regulation
MH  - Humans
MH  - *Signal Transduction
MH  - Tight Junctions/genetics/*metabolism/pathology
OTO - NOTNLM
OT  - blood-brain barrier
OT  - cell adhesion
OT  - claudin
OT  - neurovascular unit
OT  - nuclear receptor
OT  - tight junction
EDAT- 2021/03/12 06:00
MHDA- 2021/11/30 06:00
CRDT- 2021/03/11 07:14
PHST- 2021/02/14 00:00 [revised]
PHST- 2021/01/11 00:00 [received]
PHST- 2021/02/25 00:00 [accepted]
PHST- 2021/03/12 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2021/03/11 07:14 [entrez]
AID - 10.1002/jcp.30357 [doi]
PST - ppublish
SO  - J Cell Physiol. 2021 Oct;236(10):7134-7143. doi: 10.1002/jcp.30357. Epub 2021 Mar 
      10.