PMID- 33705353
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210726
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 8
DP  - 2021 Mar 11
TI  - High expression of CD52 in adipocytes: a potential therapeutic target for obesity 
      with type 2 diabetes.
PG  - 11043-11060
LID - 10.18632/aging.202714 [doi]
AB  - The aim of the present study was to evaluate the involvement of CD52 in 
      adipocytes as well as to explore its effect on type 2 diabetes mellitus (T2DM), 
      and to improve our understanding of the potential molecular events of obesity 
      with type 2 diabetes. Global changes in the CD52 expression patterns were 
      detected in adipocytes and preadipocytes derived from obese and lean individuals. 
      In particular, CD52 was identified as significantly differentially upregulated 
      and was analyzed, both in vitro and in vivo, using various approaches. In vitro 
      experiments, CD52 was a significantly up-regulated mRNA in mature adipocytes and 
      preadipocytes. In addition, CD52 gradually increased with the differentiation of 
      preadipocytes. In vivo experiments, the expression of CD52 in high-fat diet (HFD) 
      -fed mice tended to be higher than that in regular diet (RD) -fed mice. Further 
      analysis showed that CD52 expression was positively correlated with Smad3 and 
      TGF-beta in mice, and the downregulation of CD52 was accompanied by increased 
      glucose tolerance and insulin sensitivity. Moreover, a comparison of 
      CD4+CD52(high) T cells and CD4+CD52(low) T cells showed that many T2DM-related 
      genes were aberrantly expressed. Overall, CD52 may functioned as an important 
      potential target for obesity with T2DM via TGF-beta/Smad3 axis.
FAU - Mao, Rui
AU  - Mao R
AD  - The Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's 
      Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 
      Chengdu 610031, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Emergency Department, Third Clinical Medical College, Peking University, Beijing 
      100191, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - The Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's 
      Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 
      Chengdu 610031, China.
FAU - Liu, Hongtao
AU  - Liu H
AD  - The Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's 
      Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 
      Chengdu 610031, China.
FAU - Guo, Pengsen
AU  - Guo P
AD  - The Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's 
      Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 
      Chengdu 610031, China.
FAU - Liu, Yanjun
AU  - Liu Y
AD  - The Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's 
      Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 
      Chengdu 610031, China.
FAU - Zhang, Tongtong
AU  - Zhang T
AD  - The Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's 
      Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 
      Chengdu 610031, China.
AD  - Medical Research Center, The Third People's Hospital of Chengdu, The Second 
      Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu 610031, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210311
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (CD52 Antigen)
RN  - 0 (CD52 protein, human)
RN  - 0 (Cd52 protein, mouse)
RN  - 0 (SMAD3 protein, human)
RN  - 0 (Smad3 Protein)
RN  - 0 (Smad3 protein, mouse)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Adipocytes/*pathology
MH  - Animals
MH  - CD52 Antigen/*genetics/metabolism
MH  - Cell Differentiation/genetics/immunology
MH  - Cells, Cultured
MH  - Datasets as Topic
MH  - Diabetes Mellitus, Type 2/*genetics/immunology/pathology
MH  - Diet, High-Fat/adverse effects
MH  - Gene Expression Profiling
MH  - Gene Regulatory Networks
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Intra-Abdominal Fat/cytology
MH  - Lymphocyte Activation/genetics
MH  - Mice
MH  - Mice, Knockout
MH  - Obesity/*complications/genetics/immunology/pathology
MH  - Primary Cell Culture
MH  - Prospective Studies
MH  - Protein Interaction Maps/genetics
MH  - Signal Transduction/genetics/immunology
MH  - Smad3 Protein/genetics/metabolism
MH  - T-Lymphocytes/immunology/metabolism
MH  - Transforming Growth Factor beta/metabolism
MH  - Up-Regulation
PMC - PMC8109061
OTO - NOTNLM
OT  - CD52
OT  - T2DM
OT  - TGF-beta
OT  - obesity
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interest.
EDAT- 2021/03/12 06:00
MHDA- 2021/07/27 06:00
PMCR- 2021/04/30
CRDT- 2021/03/11 17:18
PHST- 2020/11/24 00:00 [received]
PHST- 2021/02/03 00:00 [accepted]
PHST- 2021/03/12 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
PHST- 2021/03/11 17:18 [entrez]
PHST- 2021/04/30 00:00 [pmc-release]
AID - 202714 [pii]
AID - 10.18632/aging.202714 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 Mar 11;13(8):11043-11060. doi: 10.18632/aging.202714. 
      Epub 2021 Mar 11.