PMID- 33707377
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 2212-554X (Electronic)
IS  - 2212-5531 (Linking)
VI  - 10
IP  - 1
DP  - 2021 Jan-Mar
TI  - Immune reconstitution inflammatory syndrome in Mycobacterium chimaera 
      mediastinitis: When clinical judgment trumps imaging.
PG  - 82-84
LID - 10.4103/ijmy.ijmy_242_20 [doi]
AB  - Mycobacterium chimaera has been described in postoperative cardiovascular 
      procedures in patients after an outbreak of contaminated 3T heater-cooler units. 
      Immune reconstitution inflammatory syndrome (IRIS) has been mostly reported in 
      immunocompromised patients, especially HIV after starting therapy. Our case is a 
      52-year-old immunocompetent male who was diagnosed with M. chimaera mediastinitis 
      a year after Type A dissection repair and was started on quadruple antimicrobial 
      therapy. He clinically improved but 8 months into therapy he presented with a 
      declining kidney function, pancytopenia, and hypercalcemia which after bone 
      marrow and kidney biopsies were attributed to IRIS. Our patient's diagnosis 
      spared him subsequent surgery. IRIS during the treatment of nontuberculous 
      mycobacteria must be suspected even in immunocompetent patients as reaching the 
      diagnosis is very helpful in preventing additional diagnostic and therapeutic 
      measures.
FAU - Haddad, Sara
AU  - Haddad S
AD  - Department of Internal Medicine, Lankenau Medical Center, Wynnewood, PA, USA.
FAU - Tayyar, Ralph
AU  - Tayyar R
AD  - Department of Internal Medicine, Lankenau Medical Center, Wynnewood, PA, USA.
FAU - Jr, Lawrence Livornese
AU  - Jr LL
AD  - Division of Infectious Diseases, Lankenau Medical Center, Wynnewood, PA, USA.
FAU - Lande, Leah
AU  - Lande L
AD  - Division of Pulmonary and Critical Care, Lankenau Medical Center, Wynnewood, PA, 
      USA.
FAU - Santoro, Jerome
AU  - Santoro J
AD  - Division of Infectious Diseases, Lankenau Medical Center, Wynnewood, PA, USA.
LA  - eng
PT  - Case Reports
PL  - India
TA  - Int J Mycobacteriol
JT  - International journal of mycobacteriology
JID - 101615660
RN  - Mycobacterium chimaera
SB  - IM
MH  - Humans
MH  - *Immune Reconstitution Inflammatory Syndrome
MH  - Judgment
MH  - Male
MH  - *Mediastinitis/diagnosis
MH  - Middle Aged
MH  - *Mycobacterium
OTO - NOTNLM
OT  - Immune reconstitution inflammatory syndrome
OT  - Mycobacterium chimaera
OT  - mediastinitis
OT  - nontuberculous mycobacterium
OT  - postoperative cardiovascular infections
COIS- None
EDAT- 2021/03/13 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/03/12 06:28
PHST- 2021/03/12 06:28 [entrez]
PHST- 2021/03/13 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
AID - IntJMycobacteriol_2021_10_1_82_310513 [pii]
AID - 10.4103/ijmy.ijmy_242_20 [doi]
PST - ppublish
SO  - Int J Mycobacteriol. 2021 Jan-Mar;10(1):82-84. doi: 10.4103/ijmy.ijmy_242_20.