PMID- 33708880 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220421 IS - 2305-5839 (Print) IS - 2305-5847 (Electronic) IS - 2305-5839 (Linking) VI - 9 IP - 3 DP - 2021 Feb TI - Post hoc analysis of two clinical trials to compare the immunogenicity and safety of different polio immunization schedules in Chinese infants. PG - 253 LID - 10.21037/atm-20-2537 [doi] LID - 253 AB - BACKGROUND: A comparative analysis of the immunogenicity and safety of different poliovirus immunization schedules in Chinese infants is imperative to guide the administration of efficient strategies for the eradication of poliomyelitis. METHODS: A post hoc analysis was conducted with the data from two poliovirus vaccine clinical trials involving a combined total of 2,400 infants aged 60-90 days. Trivalent oral poliovirus vaccine (tOPV), bivalent oral poliovirus vaccine (bOPV), Sabin strain-based inactivated poliovirus vaccine (sIPV), and conventional inactivated poliovirus vaccine (cIPV) were used in different schedules, the immunogenicity and safety of which were compared 28 days after the last of three doses. RESULTS: In a per-protocol set analysis, the tOPV-tOPV-tOPV schedule induced seroconversion in 99.1%, 98.2%, and 96.0% of the inoculated infants for poliovirus type I, II, and III, respectively. The seroconversions for poliovirus types I and III were each almost 100% after immunization with the cIPV-bOPV-bOPV, sIPV-sIPV-bOPV, cIPV-cIPV-bOPV, sIPV-sIPV-tOPV, cIPV-cIPV-tOPV, or sIPV-bOPV-bOPV schedule. However, the schedules that used one IPV dose followed by two (poliovirus type I and III) bOPV doses failed to induce high-level immunity against type II poliovirus. IPV-related schedules were associated with a slightly higher incidence of adverse events (AEs). CONCLUSIONS: If the capacity of IPV can be increased, two or more doses of IPV should be administered before vaccination with bOPV in a sequential schedule to improve immunity against type II poliovirus. CI - 2021 Annals of Translational Medicine. All rights reserved. FAU - Zhao, Ting AU - Zhao T AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Mo, Zhaojun AU - Mo Z AD - Guangxi Province Center for Disease Control and Prevention, Nanning, China. FAU - Ying, Zhifang AU - Ying Z AD - National Institutes for Food and Drug Control, Beijing, China. FAU - Huang, Teng AU - Huang T AD - Guangxi Province Center for Disease Control and Prevention, Nanning, China. FAU - Che, Yanchun AU - Che Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Li, Guoliang AU - Li G AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Yang, Xiaolei AU - Yang X AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Sun, Mingbo AU - Sun M AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Jiang, Li AU - Jiang L AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Shi, Li AU - Shi L AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Ye, Hui AU - Ye H AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Zhao, Zhimei AU - Zhao Z AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Liu, Xiaochang AU - Liu X AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Li, Jing AU - Li J AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Li, Yanping AU - Li Y AD - Guangxi Province Center for Disease Control and Prevention, Nanning, China. FAU - Li, Rongcheng AU - Li R AD - Guangxi Province Center for Disease Control and Prevention, Nanning, China. FAU - Jiang, Ruiju AU - Jiang R AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Wang, Jianfeng AU - Wang J AD - National Institutes for Food and Drug Control, Beijing, China. FAU - Fu, Yuting AU - Fu Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Ma, Rufei AU - Ma R AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Shi, Hongyuan AU - Shi H AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Yang, Huan AU - Yang H AD - Center for Drug Evaluation, China Food and Drug Administration, Beijing, China. FAU - Li, Changgui AU - Li C AD - National Institutes for Food and Drug Control, Beijing, China. FAU - Yang, Jingsi AU - Yang J AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. FAU - Li, Qihan AU - Li Q AD - Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. LA - eng PT - Journal Article PL - China TA - Ann Transl Med JT - Annals of translational medicine JID - 101617978 PMC - PMC7940937 OTO - NOTNLM OT - Poliovirus sequential vaccination schedule OT - immunogenicity OT - inactivated poliovirus vaccine (IPV) OT - oral poliovirus vaccine (OPV) OT - safety COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-2537). The authors have no conflicts of interest to declare. EDAT- 2021/03/13 06:00 MHDA- 2021/03/13 06:01 PMCR- 2021/02/01 CRDT- 2021/03/12 07:20 PHST- 2021/03/12 07:20 [entrez] PHST- 2021/03/13 06:00 [pubmed] PHST- 2021/03/13 06:01 [medline] PHST- 2021/02/01 00:00 [pmc-release] AID - atm-09-03-253 [pii] AID - 10.21037/atm-20-2537 [doi] PST - ppublish SO - Ann Transl Med. 2021 Feb;9(3):253. doi: 10.21037/atm-20-2537.