PMID- 33709017
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211203
IS  - 2366-3987 (Electronic)
IS  - 2366-3987 (Linking)
VI  - 3
IP  - 12
DP  - 2020 Dec
TI  - HDL nanoparticles have wound healing and anti-inflammatory properties and can 
      topically deliver miRNAs.
LID - 2000138 [pii]
LID - 10.1002/adtp.202000138 [doi]
AB  - microRNAs regulate numerous biological processes, making them potential 
      therapeutic agents. Problems with delivery and stability of these molecules have 
      limited their usefulness as treatments. We demonstrate that synthetic 
      high-density lipoprotein nanoparticles (HDL NPs) topically applied to the intact 
      ocular surface are taken up by epithelial and stromal cells. microRNAs complexed 
      to HDL NPs (miR-HDL NPs) are similarly taken up by cells and tissues and retain 
      biological activity. Topical treatment of diabetic mice with either HDL NPs or 
      miR-HDL NPs significantly improved corneal re-epithelialization following 
      wounding compared with controls. Mouse corneas with alkali burn-induced 
      inflammation, topically treated with HDL NPs, displayed clinical, morphological 
      and immunological improvement. These results should yield a novel HDL NP-based 
      eye drop for patients with compromised wound healing ability (diabetics) and/or 
      corneal inflammatory diseases (e.g. dry eye).
FAU - Wang, Junyi
AU  - Wang J
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL.
AD  - Department of Ophthalmology, The Third Medical Center of Chinese PLA General 
      Hospital, Beijing, China.
FAU - Calvert, Andrea E
AU  - Calvert AE
AD  - Department of Urology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL.
FAU - Kaplan, Nihal
AU  - Kaplan N
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL.
FAU - McMahon, Kaylin M
AU  - McMahon KM
AD  - Department of Urology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL.
FAU - Yang, Wending
AU  - Yang W
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL.
FAU - Lu, Kurt Q
AU  - Lu KQ
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL.
FAU - Peng, Han
AU  - Peng H
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL.
FAU - Thaxton, C Shad
AU  - Thaxton CS
AD  - Department of Urology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL.
FAU - Lavker, Robert M
AU  - Lavker RM
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL.
LA  - eng
GR  - P30 AR057216/AR/NIAMS NIH HHS/United States
GR  - S10 OD021704/OD/NIH HHS/United States
GR  - P30 CA060553/CA/NCI NIH HHS/United States
GR  - R01 EY006769/EY/NEI NIH HHS/United States
GR  - R01 EY019463/EY/NEI NIH HHS/United States
GR  - T32 AR060710/AR/NIAMS NIH HHS/United States
GR  - U01 AR064144/AR/NIAMS NIH HHS/United States
GR  - U01 AR071168/AR/NIAMS NIH HHS/United States
GR  - T32 GM008061/GM/NIGMS NIH HHS/United States
GR  - F32 EY006769/EY/NEI NIH HHS/United States
GR  - R01 EY028560/EY/NEI NIH HHS/United States
GR  - P30 AR075049/AR/NIAMS NIH HHS/United States
PT  - Journal Article
DEP - 20200930
PL  - Germany
TA  - Adv Ther (Weinh)
JT  - Advanced therapeutics
JID - 101724632
PMC - PMC7941746
MID - NIHMS1636016
OTO - NOTNLM
OT  - Corneal epithelium
OT  - EphA2
OT  - alkali burn
OT  - diabetic cornea
OT  - microRNA
COIS- CONFLICT OF INTEREST The authors declare no conflict of interest.
EDAT- 2021/03/13 06:00
MHDA- 2021/03/13 06:01
PMCR- 2021/12/01
CRDT- 2021/03/12 07:21
PHST- 2021/03/12 07:21 [entrez]
PHST- 2021/03/13 06:00 [pubmed]
PHST- 2021/03/13 06:01 [medline]
PHST- 2021/12/01 00:00 [pmc-release]
AID - 2000138 [pii]
AID - 10.1002/adtp.202000138 [doi]
PST - ppublish
SO  - Adv Ther (Weinh). 2020 Dec;3(12):2000138. doi: 10.1002/adtp.202000138. Epub 2020 
      Sep 30.