PMID- 33709325
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210507
IS  - 2193-8245 (Print)
IS  - 2193-6528 (Electronic)
VI  - 10
IP  - 2
DP  - 2021 Jun
TI  - A Randomized Study of the Impact of a Corneal Pre-Cut During Cataract Surgery on 
      Wound Architecture and Corneal Astigmatism.
PG  - 313-320
LID - 10.1007/s40123-021-00339-0 [doi]
AB  - INTRODUCTION: The aim of the current study was to assess the effect of a 600-microm 
      corneal pre-cut on wound architecture and its impact on surgically induced 
      astigmatism. The images were acquired intraoperatively and postoperatively with 
      high-resolution spectral-domain optical coherence tomography (SD-OCT). METHODS: 
      This study included patients scheduled for cataract surgery. Preoperatively, 
      optical biometry and corneal topography were performed (IOL Master 500 and Atlas 
      9000, both Carl Zeiss Meditec AG, Germany). The first eye randomly received a 
      600-microm corneal pre-cut during cataract surgery, or a single-plane stab-incision 
      and the second eye received the other incision technique. Incision architecture 
      was assessed intraoperatively using a continuous intraoperative optical coherence 
      tomography (iOCT) device (ReScan 700, Carl Zeiss Meditec AG, Germany) at three 
      time points: after the incision, after irrigation/aspiration and after 
      intraocular lens (IOL) implantation. Additionally, OCT (Spectralis, Heidelberg 
      Engineering, Germany) measurements were performed 1 h, 1 week and 1 month 
      postoperatively. RESULTS: Forty eight eyes of 24 patients were analysed. The 
      pre-cut group and the stab-incision group had a significant decrease in wound 
      thickness from the 1-h to the 1-week measurement (p = 0.022 and p = 0.001). 
      Corneal astigmatism showed a vector difference from preoperatively to the 1-week 
      measurement of 0.48 D (SD, +/- 0.27) in the stab incision group and 0.49 D (SD, 
      +/- 0.24) in the stab incision group. No significant differences were found between 
      the groups. CONCLUSION: To our knowledge, this was the first study which compared 
      the wound alterations in pre-cut and stab-incision groups. TRIAL REGISTRATION: 
      NCT02155270.
FAU - Doeller, Birgit
AU  - Doeller B
AUID- ORCID: 0000-0001-6133-1469
AD  - VIROS-Vienna Institute for Research in Ocular Surgery, a Karl Landsteiner 
      Institute, Hanusch Hospital, Vienna, Austria. b.doeller@viros.at.
FAU - Hirnschall, Nino
AU  - Hirnschall N
AD  - VIROS-Vienna Institute for Research in Ocular Surgery, a Karl Landsteiner 
      Institute, Hanusch Hospital, Vienna, Austria.
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
FAU - Fichtenbaum, Maria
AU  - Fichtenbaum M
AD  - VIROS-Vienna Institute for Research in Ocular Surgery, a Karl Landsteiner 
      Institute, Hanusch Hospital, Vienna, Austria.
FAU - Nguyen, Phuong-Mai
AU  - Nguyen PM
AD  - VIROS-Vienna Institute for Research in Ocular Surgery, a Karl Landsteiner 
      Institute, Hanusch Hospital, Vienna, Austria.
FAU - Varsits, Ralph
AU  - Varsits R
AD  - VIROS-Vienna Institute for Research in Ocular Surgery, a Karl Landsteiner 
      Institute, Hanusch Hospital, Vienna, Austria.
FAU - Findl, Oliver
AU  - Findl O
AD  - VIROS-Vienna Institute for Research in Ocular Surgery, a Karl Landsteiner 
      Institute, Hanusch Hospital, Vienna, Austria. oliver@findl.at.
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK. oliver@findl.at.
LA  - eng
SI  - ClinicalTrials.gov/NCT02155270
PT  - Journal Article
DEP - 20210311
PL  - England
TA  - Ophthalmol Ther
JT  - Ophthalmology and therapy
JID - 101634502
PMC - PMC8079538
OTO - NOTNLM
OT  - Cataract surgery
OT  - Corneal astigmatism
OT  - Pre-cut
OT  - Stab-incision
EDAT- 2021/03/13 06:00
MHDA- 2021/03/13 06:01
PMCR- 2021/03/11
CRDT- 2021/03/12 07:32
PHST- 2020/12/21 00:00 [received]
PHST- 2021/02/23 00:00 [accepted]
PHST- 2021/03/13 06:00 [pubmed]
PHST- 2021/03/13 06:01 [medline]
PHST- 2021/03/12 07:32 [entrez]
PHST- 2021/03/11 00:00 [pmc-release]
AID - 10.1007/s40123-021-00339-0 [pii]
AID - 339 [pii]
AID - 10.1007/s40123-021-00339-0 [doi]
PST - ppublish
SO  - Ophthalmol Ther. 2021 Jun;10(2):313-320. doi: 10.1007/s40123-021-00339-0. Epub 
      2021 Mar 11.