PMID- 33711169
OWN - NLM
STAT- MEDLINE
DCOM- 20210824
LR  - 20210824
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 157
IP  - 5
DP  - 2021 Jun
TI  - Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms 
      related to its use and misuse.
PG  - 1714-1724
LID - 10.1111/jnc.15348 [doi]
AB  - Methylenedioxymethamphetamine (MDMA) is an amphetamine analogue that 
      preferentially stimulates the release of serotonin (5HT) and results in 
      relatively small increases in synaptic dopamine (DA). The ratio of 
      drug-stimulated increases in synaptic DA, relative to 5HT, predicts the abuse 
      liability; drugs with higher DA:5HT ratios are more likely to be abused. 
      Nonetheless, MDMA is a drug that is misused. Clinical and preclinical studies 
      have suggested that repeated MDMA exposure produces neuroadaptive responses in 
      both 5HT and DA neurotransmission that might explain the development and 
      maintenance of MDMA self-administration in some laboratory animals and the 
      development of a substance use disorder in some humans. In this paper, we 
      describe the research that has demonstrated an inhibitory effect of 5HT on the 
      acquisition of MDMA self-administration and the critical role of DA in the 
      maintenance of MDMA self-administration in laboratory animals. We then describe 
      the circuitry and 5HT receptors that are positioned to modulate DA activity and 
      review the limited research on the effects of MDMA exposure on these receptor 
      mechanisms.
CI  - (c) 2021 International Society for Neurochemistry.
FAU - Schenk, Susan
AU  - Schenk S
AUID- ORCID: 0000-0002-7786-8313
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
FAU - Highgate, Quenten
AU  - Highgate Q
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210325
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Dopamine/*physiology
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Nerve Net/physiopathology
MH  - Serotonin/*physiology
MH  - Serotonin Agents/*pharmacology
MH  - Substance-Related Disorders/*physiopathology/*psychology
OTO - NOTNLM
OT  - MDMA
OT  - dopamine
OT  - self-administration
OT  - serotonin
OT  - substance misuse
EDAT- 2021/03/13 06:00
MHDA- 2021/08/25 06:00
CRDT- 2021/03/12 17:21
PHST- 2021/03/08 00:00 [revised]
PHST- 2020/12/22 00:00 [received]
PHST- 2021/03/09 00:00 [accepted]
PHST- 2021/03/13 06:00 [pubmed]
PHST- 2021/08/25 06:00 [medline]
PHST- 2021/03/12 17:21 [entrez]
AID - 10.1111/jnc.15348 [doi]
PST - ppublish
SO  - J Neurochem. 2021 Jun;157(5):1714-1724. doi: 10.1111/jnc.15348. Epub 2021 Mar 25.