PMID- 33711213
OWN - NLM
STAT- MEDLINE
DCOM- 20211112
LR  - 20211112
IS  - 1437-4315 (Electronic)
IS  - 1431-6730 (Linking)
VI  - 402
IP  - 6
DP  - 2021 May 26
TI  - STAT3 promotes peritoneal metastasis of gastric cancer by enhancing 
      mesothelial-mesenchymal transition.
PG  - 739-748
LID - 10.1515/hsz-2021-0120 [doi]
AB  - Signal transducer and activator of transcription 3 (STAT3) is a widely-reported 
      oncogene in many human cancers, but its role in the peritoneal metastasis of 
      gastric cancer (GC) has yet to be studied. The expression level of STAT3 in GC 
      patient tissues was assessed. Stable shRNA knockdown (KD) of STAT3 was 
      established in GC cell line AGS, followed by examination of its effect on AGC 
      cell viability and proliferation, xenograft tumor growth, metastatic potential, 
      mesothelial-to-mesenchymal transition (MMT)-related properties and peritoneal 
      metastasis in a mouse model. The specific STAT3 inhibitor BP1-102 was also 
      employed to verify findings from STAT3 KD experiments. Expression of activated 
      STAT3 was upregulated in GC patient tumor tissues, and further elevated among 
      patients diagnosed with peritoneal metastasis. STAT3 deactivation suppressed 
      viability and proliferation of GC cells in vitro, as well as GC tumorigenesis in 
      vivo. Furthermore, the metastatic properties and production of MMT-inducing 
      factors of GC cells in vitro were also dependent on STAT3 activation. 
      Importantly, STAT3 KD significantly compromised peritoneal metastasis of GC in 
      vivo. STAT3 activation contributes to peritoneal metastasis of GC by promoting 
      MMT, warranting further investigation to explore its potential for GC treatment, 
      in particular among peritoneal metastasis patients.
CI  - (c) 2021 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Yang, Hongkui
AU  - Yang H
AD  - Department of Oncology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, No. 248-252 Dong Road, Quanzhou362000, Fujian, China.
FAU - Xu, Wenjun
AU  - Xu W
AUID- ORCID: 0000-0003-3928-2706
AD  - Department of Oncology, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, No. 248-252 Dong Road, Quanzhou362000, Fujian, China.
LA  - eng
PT  - Journal Article
DEP - 20210315
PL  - Germany
TA  - Biol Chem
JT  - Biological chemistry
JID - 9700112
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
SB  - IM
MH  - Animals
MH  - Cell Adhesion
MH  - Epithelial-Mesenchymal Transition
MH  - Humans
MH  - Mice
MH  - Mice, Nude
MH  - Neoplasms, Experimental/diagnosis/metabolism
MH  - STAT3 Transcription Factor/genetics/*metabolism
MH  - Stomach Neoplasms/diagnosis/*metabolism
MH  - Tumor Cells, Cultured
OTO - NOTNLM
OT  - gastric cancer
OT  - mesothelial-to-mesenchymal transition
OT  - peritoneal metastasis
OT  - signal transducer and activator of transcription 3 (STAT3)
OT  - tumor
EDAT- 2021/03/13 06:00
MHDA- 2021/11/16 06:00
CRDT- 2021/03/12 17:23
PHST- 2020/12/21 00:00 [received]
PHST- 2021/02/23 00:00 [accepted]
PHST- 2021/03/13 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/03/12 17:23 [entrez]
AID - hsz-2021-0120 [pii]
AID - 10.1515/hsz-2021-0120 [doi]
PST - epublish
SO  - Biol Chem. 2021 Mar 15;402(6):739-748. doi: 10.1515/hsz-2021-0120. Print 2021 May 
      26.