PMID- 33711216
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20221207
IS  - 2191-0286 (Electronic)
IS  - 0792-6855 (Linking)
VI  - 33
IP  - 2
DP  - 2021 Mar 15
TI  - Role of interleukin-2 and interleukin-18 in newly diagnosed type 2 diabetes 
      mellitus.
PG  - 185-190
LID - 10.1515/jbcpp-2020-0272 [doi]
AB  - OBJECTIVES: The study aimed to compare the levels of anti-inflammatory 
      interleukin-2 (IL-2) and proinflammatory interleukin-18 (IL-18) among newly 
      diagnosed type 2 diabetes mellitus (T2DM) and nondiabetic volunteers, to predict 
      their roles as markers in the diagnosis of newly diagnosed T2DM. METHODS: In the 
      study, 60 subjects were enrolled (30 T2DM cases and 30 non-diabetic controls). 
      Biochemical parameters such as fasting plasma glucose (FBS), glycated haemoglobin 
      (HbA(1c)), high sensitivity C-reactive protein (hs-CRP) and lipid profile were 
      estimated in auto-analyser. Serum IL-2 and IL-18 levels were assessed by 
      enzyme-linked immune sorbent assay (ELISA). RESULTS: Significant differences were 
      observed in the levels of interleukins among study groups. The median (95% 
      confidence interval) of IL-2 in cases and controls were 8.55 (6.07-47.23) and 
      45.87 (12.81-145.4) (p=0.02). The median (95% CI) of IL-18 on the other hand in 
      cases and controls were 691.6 (580.3-872.6) and 511.1 (452.6-557.5) (p=0.0014). 
      CONCLUSIONS: Our study is the first to correlate IL-2 and IL-18 in newly 
      diagnosed T2DM patients. Findings from this study highlight the anti-inflammatory 
      role of IL-2 and proinflammatory role of IL-18 in T2DM. ROC analysis helped 
      predict their role as markers in T2DM diagnosis.
CI  - (c) 2021 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Suri, Smriti
AU  - Suri S
AUID- ORCID: 0000-0001-6528-281X
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Mitra, Prasenjit
AU  - Mitra P
AUID- ORCID: 0000-0003-4826-1587
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Abhilasha, Abhilasha
AU  - Abhilasha A
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Saxena, Indu
AU  - Saxena I
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 
      India.
FAU - Garg, Mahendra K
AU  - Garg MK
AD  - Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Bohra, Gopal Krishna
AU  - Bohra GK
AD  - Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Sharma, Praveen
AU  - Sharma P
AUID- ORCID: 0000-0002-8324-737X
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20210315
PL  - Germany
TA  - J Basic Clin Physiol Pharmacol
JT  - Journal of basic and clinical physiology and pharmacology
JID - 9101750
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (IL18 protein, human)
RN  - 0 (IL2 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-2)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/analysis
MH  - *Diabetes Mellitus, Type 2
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - *Interleukin-18/blood
MH  - *Interleukin-2/blood
OTO - NOTNLM
OT  - inflammation
OT  - interleukin-18 (IL-18)
OT  - interleukin-2 (IL-2)
OT  - type 2 diabetes mellitus (T2DM)
EDAT- 2021/03/13 06:00
MHDA- 2022/03/31 06:00
CRDT- 2021/03/12 17:23
PHST- 2020/08/22 00:00 [received]
PHST- 2020/11/09 00:00 [accepted]
PHST- 2021/03/13 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2021/03/12 17:23 [entrez]
AID - jbcpp-2020-0272 [pii]
AID - 10.1515/jbcpp-2020-0272 [doi]
PST - epublish
SO  - J Basic Clin Physiol Pharmacol. 2021 Mar 15;33(2):185-190. doi: 
      10.1515/jbcpp-2020-0272.