PMID- 33711309
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20240226
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 899
DP  - 2021 May 15
TI  - Imperatorin alleviates metabolic and vascular alterations in 
      high-fat/high-fructose diet-fed rats by modulating adiponectin receptor 1, eNOS, 
      and p47(phox) expression.
PG  - 174010
LID - S0014-2999(21)00163-1 [pii]
LID - 10.1016/j.ejphar.2021.174010 [doi]
AB  - In the present study, the therapeutic effects of imperatorin on metabolic and 
      vascular alterations and possible underlying mechanisms were investigated in 
      high-fat/high-fructose diet (HFFD)-fed rats. Male Sprague-Dawley rats were fed a 
      high-fat diet plus 15% fructose in drinking water for 16 weeks. HFFD-fed rats 
      were treated with imperatorin (15 or 30 mg/kg/day) for the last 4 weeks. In 
      HFFD-fed rats, imperatorin significantly reduced obesity, hypertension, 
      dyslipidemia, and insulin resistance. Imperatorin markedly improved vascular 
      endothelial function and alleviated changes in vascular morphology. Furthermore, 
      imperatorin treatment significantly increased the plasma levels of the nitric 
      oxide metabolite and adiponectin, and upregulated adiponectin receptor 1 and 
      endothelial nitric oxide synthase (eNOS) protein expression in the thoracic 
      aorta. Imperatorin treatment decreased vascular superoxide anion production and 
      downregulated aortic NADPH oxidase subunit p47(phox) protein expression. These 
      findings indicated that imperatorin alleviates HFFD-induced metabolic and 
      vascular alterations in rats. The possible underlying mechanism may involve the 
      restoration of adiponectin receptor 1 and eNOS expression and suppression of 
      p47(phox) expression.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Bunbupha, Sarawoot
AU  - Bunbupha S
AD  - Faculty of Medicine, Mahasarakham University, Maha Sarakham, 44000, Thailand.
FAU - Prasarttong, Patoomporn
AU  - Prasarttong P
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand.
FAU - Poasakate, Anuson
AU  - Poasakate A
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand.
FAU - Maneesai, Putcharawipa
AU  - Maneesai P
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand; Cardiovascular Research Group, Khon Kaen University, Khon Kaen, 
      40002, Thailand.
FAU - Pakdeechote, Poungrat
AU  - Pakdeechote P
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand; Cardiovascular Research Group, Khon Kaen University, Khon Kaen, 
      40002, Thailand. Electronic address: ppoung@kku.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20210309
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Dietary Sugars)
RN  - 0 (Furocoumarins)
RN  - 0 (Receptors, Adiponectin)
RN  - 0 (adiponectin receptor 1, rat)
RN  - 30237-26-4 (Fructose)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - EC 1.14.13.39 (Nos3 protein, rat)
RN  - EC 1.6.3.- (NADPH Oxidases)
RN  - EC 1.6.3.1 (neutrophil cytosolic factor 1)
RN  - K713N25C78 (imperatorin)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/*drug effects/metabolism/physiopathology
MH  - Diet, High-Fat
MH  - Dietary Sugars
MH  - Disease Models, Animal
MH  - Dyslipidemias/enzymology/etiology/physiopathology/prevention & control
MH  - Fructose
MH  - Furocoumarins/*pharmacology
MH  - Hemodynamics/*drug effects
MH  - Hypertension/enzymology/etiology/physiopathology/*prevention & control
MH  - Insulin Resistance
MH  - Male
MH  - Metabolic Syndrome/enzymology/etiology/physiopathology/*prevention & control
MH  - NADPH Oxidases/*metabolism
MH  - Nitric Oxide/metabolism
MH  - Nitric Oxide Synthase Type III/*metabolism
MH  - Obesity/enzymology/etiology/physiopathology/prevention & control
MH  - Oxidative Stress/drug effects
MH  - Rats, Sprague-Dawley
MH  - Receptors, Adiponectin/*metabolism
MH  - Signal Transduction
MH  - Rats
OTO - NOTNLM
OT  - Adiponectin receptor 1
OT  - Endothelial nitric oxide synthase
OT  - High-fat/high-fructose diet
OT  - Imperatorin
OT  - Oxidative stress
EDAT- 2021/03/13 06:00
MHDA- 2021/05/21 06:00
CRDT- 2021/03/12 20:11
PHST- 2020/12/03 00:00 [received]
PHST- 2021/02/20 00:00 [revised]
PHST- 2021/02/28 00:00 [accepted]
PHST- 2021/03/13 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
PHST- 2021/03/12 20:11 [entrez]
AID - S0014-2999(21)00163-1 [pii]
AID - 10.1016/j.ejphar.2021.174010 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2021 May 15;899:174010. doi: 10.1016/j.ejphar.2021.174010. Epub 
      2021 Mar 9.