PMID- 33711709
OWN - NLM
STAT- MEDLINE
DCOM- 20220225
LR  - 20220225
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 172
DP  - 2021 May
TI  - Spatiotemporal distribution and age of seizure onset in a pediatric epilepsy 
      surgery cohort with cortical dysplasia.
PG  - 106598
LID - S0920-1211(21)00051-6 [pii]
LID - 10.1016/j.eplepsyres.2021.106598 [doi]
AB  - OBJECTIVE: Focal Cortical Dysplasias (CD) are a common etiology of refractory 
      pediatric epilepsy and are amenable to epilepsy surgery. We investigated the 
      association of lesion volume and location to age of seizure onset among children 
      with CD who underwent epilepsy surgery. METHODS: A retrospective study of 
      epilepsy surgery patients with pathologically-confirmed CD. Regions of interest 
      (ROI) determined preoperative lesion volumes on 1.5 T and 3 T T2 and SPGR MRIs, 
      and location in 7 distributed neural networks. Descriptive and inferential 
      statistics were used. RESULTS: Fifty-five patients were identified: 35 girls 
      (56.5 %). Median age of seizure onset: 19.0 months (range 0.02 months - 16.0 
      years). Median age of surgery: 7.8 years (range 2.89 months - 24.45 years). CD 
      were frontal (n = 21, 38 %); temporal (n = 15, 27 %); parietal (n = 10, 18 %); 
      occipital (n = 3, 5%); multilobar (n = 6, 11 %). Frontal FCD had seizure onset < 
      1-year-old (P = 0.10); temporal lobe CD seizure onset was more likely > 
      5-years-old (P= 0.06). Median lesion volume for CD was 23.23 cm(3) (range: 
      1.87-591.73 cm(3)). Larger CD lesions were associated with earlier epilepsy (P = 
      0.01, r = -0.16). We did not find that lesions proximal to early maturing 
      cortical regions were associated with earlier seizure onset. We found an 
      association with CD location in the default mode network (DMN) and age onset < 
      5years old (P = 0.03). Age of seizure onset was negatively correlated with 
      percent of CD overlapping motor cortex (P = 0.001, r =-0.794) but not with CD 
      overlap of the visual cortex (P = 0.35). There was no effect of CD type on age of 
      epilepsy onset. SIGNIFICANCE: Larger CD lesions are associated with earlier onset 
      epilepsy. CD most commonly occurs within the DMN and Limbic network, and DMN is 
      associated with seizure onset before 5-years-old. Percent of CD overlapping motor 
      cortex correlates with earlier seizure onset. These observations may reflect 
      patterns of brain maturation or regional differences in clinical expression of 
      seizures.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Wiwattanadittakul, Natrujee
AU  - Wiwattanadittakul N
AD  - Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, 
      Thailand; Center for Neuroscience, Children's National Hospital, George 
      Washington University School of Medicine, Washington DC, USA.
FAU - Suwannachote, Sirorat
AU  - Suwannachote S
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA; Department of Pediatrics, 
      Queen Sirikit National Institute of Child Health, Rungsit University, Bangkok, 
      Thailand.
FAU - You, Xiaozhen
AU  - You X
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Cohen, Nathan T
AU  - Cohen NT
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA. Electronic address: 
      ncohen@childrensnational.org.
FAU - Tran, Tan
AU  - Tran T
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Phuackchantuck, Rochana
AU  - Phuackchantuck R
AD  - Research Administration Section, Faculty of Medicine, Chiang Mai University, 
      Chiang Mai, Thailand.
FAU - Tsuchida, Tammy N
AU  - Tsuchida TN
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Depositario-Cabacar, Dewi F
AU  - Depositario-Cabacar DF
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Zelleke, Tesfaye
AU  - Zelleke T
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Schreiber, John M
AU  - Schreiber JM
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Conry, Joan A
AU  - Conry JA
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Kao, Amy
AU  - Kao A
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Bartolini, Luca
AU  - Bartolini L
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA; Department of Pediatrics, 
      Brown University, Rhode Island, USA.
FAU - Oluigbo, Chima
AU  - Oluigbo C
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Almira-Suarez, M Isabel
AU  - Almira-Suarez MI
AD  - Department of Pathology, Children's National Hospital & George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Havens, Kathryn
AU  - Havens K
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Whitehead, Matthew T
AU  - Whitehead MT
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
FAU - Gaillard, William Davis
AU  - Gaillard WD
AD  - Center for Neuroscience, Children's National Hospital, George Washington 
      University School of Medicine, Washington DC, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210302
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - *Drug Resistant Epilepsy
MH  - Electroencephalography
MH  - *Epilepsy/diagnostic imaging/surgery
MH  - *Epilepsy, Temporal Lobe
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging
MH  - *Malformations of Cortical Development/complications/diagnostic imaging/surgery
MH  - Retrospective Studies
MH  - Seizures/diagnostic imaging/etiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Default mode network
OT  - Focal cortical dysplasia
OT  - Malformations of cortical development
OT  - Network epilepsy
EDAT- 2021/03/13 06:00
MHDA- 2022/02/26 06:00
CRDT- 2021/03/12 20:25
PHST- 2020/12/14 00:00 [received]
PHST- 2021/02/04 00:00 [revised]
PHST- 2021/02/28 00:00 [accepted]
PHST- 2021/03/13 06:00 [pubmed]
PHST- 2022/02/26 06:00 [medline]
PHST- 2021/03/12 20:25 [entrez]
AID - S0920-1211(21)00051-6 [pii]
AID - 10.1016/j.eplepsyres.2021.106598 [doi]
PST - ppublish
SO  - Epilepsy Res. 2021 May;172:106598. doi: 10.1016/j.eplepsyres.2021.106598. Epub 
      2021 Mar 2.