PMID- 33711968
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20220531
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Mar 12
TI  - Dynamic monocyte chemoattractant protein-1 level as predictors of perceived pain 
      during first and second phacoemulsification eye surgeries in patients with 
      bilateral cataract.
PG  - 133
LID - 10.1186/s12886-021-01880-z [doi]
LID - 133
AB  - BACKGROUND: The purpose of the study was to investigate whether dynamic monocyte 
      chemoattractant protein-1 (MCP-1) level might be as predictors of perceived pain 
      during the first and second phacoemulsification eye surgeries in patients with 
      bilateral cataract. METHODS: Consecutive bilateral cataract patients undergoing 
      bilateral sequential phacoemulsification were retrospectively enrolled. Patients' 
      preoperative anxiety score and intraoperative pain score were registered. Aqueous 
      humor samples were obtained during surgery. MCP-1 level in the aqueous humor was 
      measured by enzyme linked immunosorbent assay (Elisa). Patients were assigned to 
      seven subgroups based on the interval between first-eye and second-eye cataract 
      surgery. Comparisons were performed for a subjective sensation and MCP-1 levels 
      among different subgroups. RESULTS: pain score during second-eye surgery was 
      significantly higher than during first-eye surgery. Whereas there was no 
      statistical difference in anxiety score between both surgeries. Result from 
      subgroups comparison showed that the visual analog scale (VAS) pain score was 
      statistically greater in 1-group and 6-group during the second eye surgery. 
      Anxiety score did not statistically differ in subgroups. Additionally, the 
      second-eye MCP-1 level was significantly higher at week 1and 6 intervals. 
      Preoperative MCP-1 level was positively correlated with perceiving pain score 
      during both surgeries. CONCLUSIONS: MCP-1 level in aqueous humor significantly 
      correlated with perceived pain during cataract surgery. Dynamic MCP-1 level could 
      function as predictors of perceived pain during the first and second 
      phacoemulsification eye surgeries in patients with bilateral cataract, which 
      might support clinicians in treatment optimization and clinical decision-making.
FAU - Zhang, Feng
AU  - Zhang F
AD  - Department of Ophthalmology, The Second Clinical Medical College, Jing Zhou 
      Central Hospital, Yangtze University, Hubei, 434020, Jing Zhou, China.
AD  - Department of Cataract, Ophthalmic Center, The Second Affiliated Hospital of 
      Jilin University, Jilin, 130041, Chang Chun, China.
FAU - Wang, Jin-Hua
AU  - Wang JH
AD  - Department of Ophthalmology, The Second Clinical Medical College, Jing Zhou 
      Central Hospital, Yangtze University, Hubei, 434020, Jing Zhou, China.
FAU - Zhao, Mei-Sheng
AU  - Zhao MS
AD  - Department of Cataract, Ophthalmic Center, The Second Affiliated Hospital of 
      Jilin University, Jilin, 130041, Chang Chun, China. zhaoms1961@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20210312
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - *Cataract/complications
MH  - Chemokine CCL2/*blood
MH  - Humans
MH  - *Pain
MH  - Pain Measurement
MH  - Pain Perception
MH  - Phacoemulsification/*adverse effects
MH  - Retrospective Studies
PMC - PMC7953781
OTO - NOTNLM
OT  - Bilateral cataract surgery
OT  - CCL2
OT  - MCP-1
OT  - Pain
OT  - Predictor
COIS- The authors declare that they have no competing interests.
EDAT- 2021/03/14 06:00
MHDA- 2021/05/15 06:00
PMCR- 2021/03/12
CRDT- 2021/03/13 05:27
PHST- 2020/10/07 00:00 [received]
PHST- 2021/02/25 00:00 [accepted]
PHST- 2021/03/13 05:27 [entrez]
PHST- 2021/03/14 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/03/12 00:00 [pmc-release]
AID - 10.1186/s12886-021-01880-z [pii]
AID - 1880 [pii]
AID - 10.1186/s12886-021-01880-z [doi]
PST - epublish
SO  - BMC Ophthalmol. 2021 Mar 12;21(1):133. doi: 10.1186/s12886-021-01880-z.