PMID- 33712677 OWN - NLM STAT- MEDLINE DCOM- 20211207 LR - 20211214 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 11 IP - 1 DP - 2021 Mar 12 TI - CT assessment of the increased density of cerebral vessels in plateau region. PG - 5851 LID - 10.1038/s41598-021-85448-3 [doi] LID - 5851 AB - In this study, the relationship between the brain parenchymal density, the cerebral vessel density, the mean corpuscular hemoglobin (MCH) content, the mean corpuscular hemoglobin concentration (MCHC), and the morbidity associated with lacunar infarction of residents living in either the plains or the plateau regions were analyzed and compared for their potential clinical implications. Clinical data from the brain CT scans of individuals living in either the plain or plateau regions (129 each) were collected. Specifically, the CT values for basal ganglia, the middle cerebral artery, and the superior sagittal sinus, along with the number of patients with lacunar infarction, were collected. In addition, the MCH and MCHC values were measured in blood samples collected within 48 h following the CT scans. For statistical analysis, an independent sample t-test, Pearson's correlation test (permutation test), and Chi-squared test were employed. The inhabitants of the plateau had a significantly higher CT value of basal ganglia, the middle cerebral artery, and superior sagittal sinus and also higher levels of MCH and MCHC in the blood (ps < 0.001) than the inhabitants of the plains region. Further, there was a significant positive correlation between the three aforementioned CT values and the MCH and MCHC findings. However, no significant differences were found in the morbidity of lacunar infarction between these two regions (p > 0.05). The inhabitants in the plateau have a significantly higher brain parenchymal density, higher CT value for cerebral vessels density, and higher blood MCH and MCHC levels in comparison with individuals occupying the plains. Concurrently, the parenchymal density and the CT values are shown to be positively correlated with the MCH and MCHC content in the blood. FAU - Zhou, Haiting AU - Zhou H AD - Department of Computed Tomography, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China. FAU - Tashi, Tsering AU - Tashi T AD - Department of Radiology, Rinbung County Health Service Center, Xigaze, Tibet, 857200, China. FAU - Zhao, Deli AU - Zhao D AD - Department of Computed Tomography, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China. FAU - Tsring, Sonam AU - Tsring S AD - Department of Radiology, Rinbung County Health Service Center, Xigaze, Tibet, 857200, China. FAU - Liang, Hongwei AU - Liang H AD - Department of Computed Tomography, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China. FAU - Zhang, Jinling AU - Zhang J AD - Department of Computed Tomography, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China. jinlingzi@163.com. LA - eng PT - Journal Article DEP - 20210312 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adolescent MH - Adult MH - Brain/*blood supply/*diagnostic imaging MH - Brain Infarction/blood/diagnostic imaging MH - Erythrocyte Indices MH - Female MH - Hematologic Tests MH - Humans MH - Male MH - Middle Aged MH - Statistics as Topic MH - *Tomography, X-Ray Computed MH - Young Adult PMC - PMC7954789 COIS- The authors declare no competing interests. EDAT- 2021/03/14 06:00 MHDA- 2021/12/15 06:00 PMCR- 2021/03/12 CRDT- 2021/03/13 06:10 PHST- 2020/04/16 00:00 [received] PHST- 2021/03/01 00:00 [accepted] PHST- 2021/03/13 06:10 [entrez] PHST- 2021/03/14 06:00 [pubmed] PHST- 2021/12/15 06:00 [medline] PHST- 2021/03/12 00:00 [pmc-release] AID - 10.1038/s41598-021-85448-3 [pii] AID - 85448 [pii] AID - 10.1038/s41598-021-85448-3 [doi] PST - epublish SO - Sci Rep. 2021 Mar 12;11(1):5851. doi: 10.1038/s41598-021-85448-3.