PMID- 33714208
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20210719
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 6
DP  - 2021 Mar 10
TI  - Long noncoding RNA LINC01638 contributes to laryngeal squamous cell cancer 
      progression by modulating miR-523-5p/BATF3 axis.
PG  - 8611-8619
LID - 10.18632/aging.202675 [doi]
AB  - Long noncoding RNA (lncRNA) plays a critical role in tumorigenesis. How lncRNA 
      regulates laryngeal squamous cell carcinoma (LSCC) progression remains poorly 
      understood. In the present study, we found that LINC01638 was highly expressed in 
      LSCC tissues. And LINC01638 expression was positively correlated with clinical 
      stage and lymph node metastasis. Patients with LINC01638 high expression 
      displayed a low survival rate. Results from CCK8, colony formation, and transwell 
      assays showed that LINC01638 knockdown suppressed the proliferation, migration 
      and invasion of LSCC cells in vitro. Animal experiments indicated that LINC01638 
      silencing attenuated tumor growth in vivo. In terms of mechanism, LINC01638 was 
      found to sponge miR-523-5p and promote BATF3 expression. In summary, our results 
      demonstrated that LINC01638/miR-523-5p/BATF3 axis plays a crucial function in 
      initiating LSCC development and may be a potential target for tumor therapy.
FAU - Zhang, Hang
AU  - Zhang H
AD  - Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China 
      Medical University, Shenyang 110004, China.
FAU - Zhao, Xudong
AU  - Zhao X
AD  - Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China 
      Medical University, Shenyang 110004, China.
FAU - Wang, Mengmeng
AU  - Wang M
AD  - The Sleep Medicine Center, Shengjing Hospital of China Medical University, 
      Shenyang 110004, China.
FAU - Ji, Wenyue
AU  - Ji W
AD  - Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China 
      Medical University, Shenyang 110004, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210310
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (BATF3 protein, human)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Basic-Leucine Zipper Transcription Factors/*genetics/metabolism
MH  - Disease Progression
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/physiology
MH  - Heterografts
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/metabolism/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - MicroRNAs/*genetics/metabolism
MH  - Middle Aged
MH  - RNA, Long Noncoding/*genetics/metabolism
MH  - Repressor Proteins/*genetics/metabolism
MH  - Signal Transduction/physiology
MH  - Squamous Cell Carcinoma of Head and Neck/genetics/metabolism/*pathology
PMC - PMC8034946
OTO - NOTNLM
OT  - BATF3
OT  - LINC01638
OT  - laryngeal squamous cell carcinoma
OT  - miR-523-5p
COIS- CONFLICTS OF INTEREST: These authors declare no conflicts of interest.
EDAT- 2021/03/14 06:00
MHDA- 2021/07/20 06:00
PMCR- 2021/03/31
CRDT- 2021/03/13 20:33
PHST- 2020/07/02 00:00 [received]
PHST- 2021/01/21 00:00 [accepted]
PHST- 2021/03/14 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2021/03/13 20:33 [entrez]
PHST- 2021/03/31 00:00 [pmc-release]
AID - 202675 [pii]
AID - 10.18632/aging.202675 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 Mar 10;13(6):8611-8619. doi: 10.18632/aging.202675. Epub 
      2021 Mar 10.