PMID- 33714428
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 1532-3129 (Electronic)
IS  - 0021-9975 (Linking)
VI  - 183
DP  - 2021 Feb
TI  - Skeletal Muscle Fibre Type Changes in an Avian Model of Hepatic Fibrosis.
PG  - 26-32
LID - S0021-9975(21)00001-3 [pii]
LID - 10.1016/j.jcpa.2021.01.001 [doi]
AB  - We investigated the susceptibility of type I and type II skeletal myofibres to 
      atrophy in hens with hepatic fibrosis induced by bile duct ligation (BDL). Seven 
      hens, approximately 2 years old, were randomly assigned to BDL (n = 4) and sham 
      surgery (SHAM) (n = 3) groups. Mean body weight and mean liver weight as a 
      percentage of mean body weight were significantly lower in the BDL group than in 
      the SHAM group at 4 weeks post surgery (P = 0.002, P = 0.005, respectively). Mean 
      plasma aspartate aminotransferase activity was slightly higher, while total 
      cholesterol (P <0.001), total bilirubin (P = 0.022) and NH(3) (P = 0.048) 
      concentrations were significantly higher in the BDL group than in the SHAM group. 
      Liver lesions were induced in all hens in the BDL group. The weights of the 
      pectoralis (PCT) (P = 0.049) and flexor perforans et perforatus digiti III (FPPD 
      III) muscles (P = 0.006) as a percentage of body weight were significantly 
      decreased in the BDL group. A significantly reduced mean myofibre cross-sectional 
      area in the PCT of BDL hens (P = 0.005) was indicative of atrophy. No significant 
      differences were observed in the fibre type composition of the PCT, 
      supracoracoideus or FPPD III muscles between the SHAM and BDL groups. However, 
      there was an approximate 43% increase in the number of type I fibres in the 
      femorotibialis lateralis of the BDL group and small angular type II fibres and 
      large round type I fibres in this muscle were characteristic of peripheral 
      neuropathy. The results suggest that type II fibres are more susceptible to 
      atrophy than type I fibres in this model of hepatic fibrosis.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Nagasao, Jun
AU  - Nagasao J
AD  - Department of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Towada, Aomori, Japan. Electronic address: 
      nagasao@vmas.kitasato-u.ac.jp.
FAU - Fukasawa, Hanae
AU  - Fukasawa H
AD  - Department of Veterinary Anatomy, School of Veterinary Medicine, Kitasato 
      University, Towada, Aomori, Japan.
FAU - Yoshioka, Kazuki
AU  - Yoshioka K
AD  - Department of Veterinary Anatomy, School of Veterinary Medicine, Kitasato 
      University, Towada, Aomori, Japan.
FAU - Miyamoto, Miki
AU  - Miyamoto M
AD  - Department of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Towada, Aomori, Japan.
FAU - Iwaki, Yuna
AU  - Iwaki Y
AD  - Department of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Towada, Aomori, Japan.
FAU - Kajiwara, Kurumi
AU  - Kajiwara K
AD  - Department of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Towada, Aomori, Japan.
FAU - Sato, Koudai
AU  - Sato K
AD  - Department of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Towada, Aomori, Japan.
FAU - Arihara, Keizo
AU  - Arihara K
AD  - Department of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Towada, Aomori, Japan.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
DEP - 20210203
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
SB  - IM
MH  - Animals
MH  - Bile Ducts
MH  - *Chickens
MH  - Female
MH  - Liver/pathology
MH  - *Liver Cirrhosis/pathology/veterinary
MH  - Muscle Fibers, Skeletal/*pathology
OTO - NOTNLM
OT  - avian
OT  - hepatic fibrosis
OT  - myopathy
OT  - skeletal muscle fibre types
EDAT- 2021/03/15 06:00
MHDA- 2021/11/09 06:00
CRDT- 2021/03/14 20:27
PHST- 2020/03/10 00:00 [received]
PHST- 2020/08/11 00:00 [revised]
PHST- 2021/01/02 00:00 [accepted]
PHST- 2021/03/14 20:27 [entrez]
PHST- 2021/03/15 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
AID - S0021-9975(21)00001-3 [pii]
AID - 10.1016/j.jcpa.2021.01.001 [doi]
PST - ppublish
SO  - J Comp Pathol. 2021 Feb;183:26-32. doi: 10.1016/j.jcpa.2021.01.001. Epub 2021 Feb 
      3.