PMID- 33714992 OWN - NLM STAT- MEDLINE DCOM- 20211229 LR - 20211229 IS - 1462-0332 (Electronic) IS - 1462-0324 (Linking) VI - 60 IP - 12 DP - 2021 Dec 1 TI - Reliability, validity and responsiveness of physical activity monitors in patients with inflammatory myopathy. PG - 5713-5723 LID - 10.1093/rheumatology/keab236 [doi] AB - OBJECTIVE: Idiopathic inflammatory myopathies (IIMs) cause proximal muscle weakness, which affects the ability to carry out the activities of daily living. Wearable physical activity monitors (PAMs) objectively assess continuous activity and potentially have clinical usefulness in the assessment of IIMs. We examined the psychometric characteristics for PAM outcomes in IIMs. METHODS: Adult IIM patients were prospectively evaluated (at baseline, 3 months and 6 months) in an observational study. A waist-worn PAM (ActiGraph GT3X-BT) assessed average step counts/minute, peak 1-minute cadence, and vector magnitude/minute. Validated myositis core set measures (CSMs) including manual muscle testing (MMT), physician global disease activity (MD global), patient global disease activity (Pt global), extramuscular disease activity (Ex-muscular global), HAQ-DI (HAQ disability index), muscle enzymes, and patient-reported physical function were evaluated. Test-retest reliability, construct validity, and responsiveness were determined for PAM measures and CSMs, using Pearson correlations and other appropriate analyses. RESULTS: A total of 50 adult IIM patients enrolled [mean (s.d.) age, 53.6 (14.6); 60% female, 94% Caucasian]. PAM measures showed strong test-retest reliability, moderate-to-strong correlations at baseline with MD global (r = -0.37 to -0.48), Pt global (r=-0.43 to -0.61), HAQ-DI (r = -0.47 to -0.59) and MMT (r = 0.37-0.52), and strong discriminant validity for categorical MMT and HAQ-DI. Longitudinal associations with MD global (r=-0.38 to -0.44), MMT (r = 0.50-0.57), HAQ-DI (r = -0.45 to -0.55) and functional tests (r = 0.30-0.65) were moderate to strong. PAM measures were responsive to MMT improvement >/=10% and moderate-to-major improvement on ACR/EULAR myositis response criteria. Peak 1-minute cadence had the largest effect size and standardized response means. CONCLUSION: PAM measures showed promising construct validity, reliability, and longitudinal responsiveness; especially peak 1-minute cadence. PAMs are able to provide valid outcome measures for future use in IIM clinical trials. CI - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com. FAU - Rockette-Wagner, Bonny AU - Rockette-Wagner B AUID- ORCID: 0000-0002-4096-917X AD - Department of Epidemiology. FAU - Saygin, Didem AU - Saygin D AD - Department of Medicine. FAU - Moghadam-Kia, Siamak AU - Moghadam-Kia S AD - Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. FAU - Oddis, Chester AU - Oddis C AD - Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. FAU - Landon-Cardinal, Oceane AU - Landon-Cardinal O AD - Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitie-Salpetriere University Hospital, Assistance Publique-Hopitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Inserm U974, Sorbonne Universite, Paris, France. AD - Division of Rheumatology and Research Center, Department of Medicine, University of Montreal, Centre Hospitalier de L'Universite de Montreal, Montreal, Quebec, Canada. FAU - Allenbach, Yves AU - Allenbach Y AD - Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitie-Salpetriere University Hospital, Assistance Publique-Hopitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Inserm U974, Sorbonne Universite, Paris, France. AD - Institute of Myology, Neuromuscular Investigation Center, Pitie-Salpetriere University Hospital, Paris, France. FAU - Dzanko, Sedin AU - Dzanko S AD - Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. FAU - Koontz, Diane AU - Koontz D AD - Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. FAU - Neiman, Nicole AU - Neiman N AD - Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. FAU - Aggarwal, Rohit AU - Aggarwal R AD - Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. LA - eng GR - Myositis Association/ PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't PL - England TA - Rheumatology (Oxford) JT - Rheumatology (Oxford, England) JID - 100883501 SB - IM MH - *Attitude to Health MH - Equipment Design MH - Exercise/*physiology MH - Exercise Test/methods MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Monitoring, Physiologic/*instrumentation MH - Myositis/*physiopathology/psychology MH - Prospective Studies MH - *Quality of Life MH - Reproducibility of Results OTO - NOTNLM OT - human activities OT - myositis and muscle disease OT - outcome measures OT - patient attitude to health OT - quality of life OT - remote monitoring OT - telemedicine EDAT- 2021/03/15 06:00 MHDA- 2021/12/30 06:00 CRDT- 2021/03/14 20:56 PHST- 2020/08/12 00:00 [received] PHST- 2021/02/23 00:00 [revised] PHST- 2021/03/15 06:00 [pubmed] PHST- 2021/12/30 06:00 [medline] PHST- 2021/03/14 20:56 [entrez] AID - 6170650 [pii] AID - 10.1093/rheumatology/keab236 [doi] PST - ppublish SO - Rheumatology (Oxford). 2021 Dec 1;60(12):5713-5723. doi: 10.1093/rheumatology/keab236.