PMID- 33715080
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210326
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 12
IP  - 4
DP  - 2021 Apr
TI  - Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?
PG  - 965-968
LID - 10.1007/s13300-021-01044-8 [doi]
AB  - Metformin remains the cornerstone of management for type 2 diabetes mellitus 
      (T2DM). It is also known that it has beneficial pleiotropic actions. In addition, 
      there is emerging evidence that this agent may prove beneficial in ameliorating 
      depression in T2DM. The underlying mechanisms of this new action remain elusive, 
      but experimental studies point to improved synaptic function and increased 
      serotonin activity, along with the known inflammatory and antioxidant properties 
      of metformin. Obviously, we need to further explore the potential utility of such 
      antidepressant effects among T2DM subjects in everyday reality.
FAU - Papachristou, Stella
AU  - Papachristou S
AD  - Diabetes Centre, Second Department of Internal Medicine, Democritus University of 
      Thrace, Alexandroupolis, Greece.
FAU - Papanas, Nikolaos
AU  - Papanas N
AUID- ORCID: 0000-0002-7320-785X
AD  - Diabetes Centre, Second Department of Internal Medicine, Democritus University of 
      Thrace, Alexandroupolis, Greece. papanasnikos@yahoo.gr.
LA  - eng
PT  - Editorial
DEP - 20210314
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC7955898
OTO - NOTNLM
OT  - Antidiabetic treatment
OT  - Depression
OT  - Metformin
OT  - Pleiotropic
OT  - Type 2 diabetes
EDAT- 2021/03/15 06:00
MHDA- 2021/03/15 06:01
PMCR- 2021/03/14
CRDT- 2021/03/14 21:00
PHST- 2021/02/10 00:00 [received]
PHST- 2021/02/26 00:00 [accepted]
PHST- 2021/03/15 06:00 [pubmed]
PHST- 2021/03/15 06:01 [medline]
PHST- 2021/03/14 21:00 [entrez]
PHST- 2021/03/14 00:00 [pmc-release]
AID - 10.1007/s13300-021-01044-8 [pii]
AID - 1044 [pii]
AID - 10.1007/s13300-021-01044-8 [doi]
PST - ppublish
SO  - Diabetes Ther. 2021 Apr;12(4):965-968. doi: 10.1007/s13300-021-01044-8. Epub 2021 
      Mar 14.