PMID- 3371587
OWN - NLM
STAT- MEDLINE
DCOM- 19880714
LR  - 20190908
IS  - 0272-0590 (Print)
IS  - 0272-0590 (Linking)
VI  - 10
IP  - 3
DP  - 1988 Apr
TI  - Evaluation of spermatogenesis and sperm quality in the rat following acute 
      inhalation exposure to methyl bromide.
PG  - 490-8
AB  - Methyl chloride (MeCl) and methyl bromide (MeBr) have similar target organ 
      specificities in the male F-344 rat, and MeCl is a known reproductive toxicant in 
      that species. Recently, both acute and subchronic inhalation exposures to MeBr 
      were found to produce varying degrees of testicular alteration (S.L. Eustis, S.B. 
      Haber, R.T. Drew, and R.S.H. Yang, 1986, Toxicologist, 6, 54; N. Kato, S. 
      Morinobu, and S. Ishizu, 1986, Ind. Health, 24, 87-103; M.E. Hurtt, K.T. Morgan, 
      and P.K. Working, 1987, Fundam. Appl. Toxicol., 9, 352-365). The present study 
      examined the reproductive effects of MeBr in the male F-344 rat. Adult males 
      (11-13 weeks) were exposed by inhalation to 0 or 200 ppm MeBr 6 hr/day for 5 days 
      (first day of exposure = Day 1). Ten animals from each group were anesthetized 
      with pentobarbital and terminated on Days 1, 3, 5, and 8. Additionally, five 
      males from each group were killed on Days 6, 10, 17, 24, 38, 52, and 73. Plasma 
      testosterone concentration was reduced during and immediately following exposure 
      (Days 1, 3, 5, and 6), but returned to control levels by Day 8. Nonprotein 
      sulfhydryl (NPSH) content of the liver and testis was reduced during exposure but 
      returned to control levels by Day 8 (3 days postexposure). No other reproductive 
      indices, including testis weight, daily sperm production, cauda epididymal sperm 
      count, sperm morphology, percentage motile sperm, linear sperm velocity, and 
      epididymal and testicular histology, were affected by MeBr exposure at any time 
      point examined. Thus, although MeBr causes a transient decrease in plasma 
      testosterone and testicular NPSH concentrations during acute exposure, it has no 
      lasting effect on sperm quality or spermatogenesis in the F-344 rat.
FAU - Hurtt, M E
AU  - Hurtt ME
AD  - Department of Genetic Toxicology, Chemical Industry Institute of Toxicology, 
      Research Triangle Park, North Carolina 27709.
FAU - Working, P K
AU  - Working PK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fundam Appl Toxicol
JT  - Fundamental and applied toxicology : official journal of the Society of 
      Toxicology
JID - 8200838
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Sulfhydryl Compounds)
RN  - 3XMK78S47O (Testosterone)
RN  - 9V42E1Z7B6 (methyl bromide)
SB  - IM
MH  - Administration, Inhalation
MH  - Animals
MH  - Body Weight/drug effects
MH  - Epididymis/drug effects
MH  - Hydrocarbons, Brominated/*toxicity
MH  - Male
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Inbred F344
MH  - Spermatogenesis/*drug effects
MH  - Spermatozoa/*drug effects
MH  - Sulfhydryl Compounds/blood
MH  - Testis/drug effects
MH  - Testosterone/blood
EDAT- 1988/04/01 00:00
MHDA- 1988/04/01 00:01
CRDT- 1988/04/01 00:00
PHST- 1988/04/01 00:00 [pubmed]
PHST- 1988/04/01 00:01 [medline]
PHST- 1988/04/01 00:00 [entrez]
AID - 10.1016/0272-0590(88)90295-3 [doi]
PST - ppublish
SO  - Fundam Appl Toxicol. 1988 Apr;10(3):490-8. doi: 10.1016/0272-0590(88)90295-3.