PMID- 33716257
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20211129
IS  - 1881-7823 (Electronic)
IS  - 1881-7815 (Linking)
VI  - 15
IP  - 2
DP  - 2021 May 11
TI  - The role of Toll-like receptors in neurobiology of alcoholism.
PG  - 74-82
LID - 10.5582/bst.2021.01041 [doi]
AB  - Alcoholism is a global socially significant problem and still remains one of the 
      leading causes of disability and premature death. One of the main signs of the 
      disease is the loss of cognitive control over the amount of alcohol consumed. 
      Among the mechanisms of the development of this pathology, changes in neuroimmune 
      mechanisms occurring in the brain during prolonged alcohol consumption and its 
      withdrawal have recently become the focus of numerous studies. Ethanol 
      consumption leads to the activation of neuroimmune signaling in the central 
      nervous system through many subtypes of Toll-like receptors (TLRs), as well as 
      release of their endogenous agonists (high-mobility group protein B1 (HMGB1), 
      S100 protein, heat shock proteins (HSPs), and extracellular matrix degradation 
      proteins). TLR activation triggers intracellular molecular cascades of reactions 
      leading to increased expression of genes of the innate immune system, 
      particularly, proinflammatory cytokines, causing further development of a 
      persistent neuroinflammatory process in the central nervous system. This leads to 
      death of neurons and neuroglial cells in various brain structures, primarily in 
      those associated with the development of a pathological craving for alcohol. In 
      addition, there is evidence that some subtypes of TLRs (TLR3, TLR4) are able to 
      form heterodimers with neuropeptide receptors, thereby possibly playing other 
      roles in the central nervous system, in addition to participating in the 
      activation of the innate immune system.
FAU - Airapetov, Marat
AU  - Airapetov M
AD  - Department of Neuropharmacology, Institute of Experimental Medicine, St. 
      Petersburg, Russia.
AD  - Department of Pharmacology, St. Petersburg State Pediatric Medical University, 
      St. Petersburg, Russia.
FAU - Eresko, Sergei
AU  - Eresko S
AD  - Department of Neuropharmacology, Institute of Experimental Medicine, St. 
      Petersburg, Russia.
AD  - Research and Education Center for Molecular and Cellular Technologies, St. 
      Petersburg State Chemical Pharmaceutical University, St Petersburg, Russia.
FAU - Lebedev, Andrei
AU  - Lebedev A
AD  - Department of Neuropharmacology, Institute of Experimental Medicine, St. 
      Petersburg, Russia.
FAU - Bychkov, Evgenii
AU  - Bychkov E
AD  - Department of Neuropharmacology, Institute of Experimental Medicine, St. 
      Petersburg, Russia.
FAU - Shabanov, Petr
AU  - Shabanov P
AD  - Department of Neuropharmacology, Institute of Experimental Medicine, St. 
      Petersburg, Russia.
AD  - Department of Pharmacology, Kirov Military Medical Academy, St. Petersburg, 
      Russia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210312
PL  - Japan
TA  - Biosci Trends
JT  - Bioscience trends
JID - 101502754
RN  - 0 (Toll-Like Receptors)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcoholism/*immunology/metabolism/pathology
MH  - Animals
MH  - Apoptosis/drug effects/immunology
MH  - Brain/immunology/metabolism/pathology
MH  - *Craving
MH  - Disease Models, Animal
MH  - Ethanol/administration & dosage/*adverse effects
MH  - Humans
MH  - Neuroimmunomodulation/*drug effects
MH  - Neurons/drug effects/immunology/pathology
MH  - Signal Transduction/immunology
MH  - Toll-Like Receptors/agonists/*metabolism
OTO - NOTNLM
OT  - Toll-like receptors
OT  - alcoholism
OT  - brain
OT  - neuroimmune signaling
OT  - neuroinflammation
EDAT- 2021/03/16 06:00
MHDA- 2021/11/30 06:00
CRDT- 2021/03/15 06:45
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2021/03/15 06:45 [entrez]
AID - 10.5582/bst.2021.01041 [doi]
PST - ppublish
SO  - Biosci Trends. 2021 May 11;15(2):74-82. doi: 10.5582/bst.2021.01041. Epub 2021 
      Mar 12.