PMID- 33716719
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 13
DP  - 2021
TI  - The Association of Suppressed Hypoxia-Inducible Factor-1 Transactivation of 
      Angiogenesis With Defective Recovery From Cerebral Ischemic Injury in Aged Rats.
PG  - 648115
LID - 10.3389/fnagi.2021.648115 [doi]
LID - 648115
AB  - Elderly patients suffer more brain damage in comparison with young patients from 
      the same ischemic stroke. The present study was undertaken to test the hypothesis 
      that suppressed hypoxia-inducible factor-1 (HIF-1) transcription activity is 
      responsible for defective recovery after ischemic stroke in the elders. Aged and 
      young rats underwent 1-h transient middle cerebral artery occlusion (MCAO) to 
      produce cerebral ischemic injury. The initial cerebral infarct volume in the 
      young gradually declined as time elapsed, but in the aged rats remained the same. 
      The defective recovery in the aged was associated with depressed angiogenesis and 
      retarded neurorestoration. There was no difference in HIF-1alpha accumulation in the 
      brain between the two age groups, but the expression of HIF-1 regulated genes 
      involved in cerebral recovery was suppressed in the aged. In confirmation, 
      inhibition of HIF-1 transactivation of gene expression in the young suppressed 
      cerebral recovery from MCAO as the same as that observed in the aged rats. 
      Furthermore, a copper metabolism MURR domain 1 (COMMD1) was significantly 
      elevated after MCAO only in the brain of aged rats, and suppression of COMMD1 by 
      siRNA targeting COMMD1 restored HIF-1 transactivation and improved recovery from 
      MCAO-induced damage in the aged brain. These results demonstrate that impaired 
      HIF-1 transcription activity, due at least partially to overexpression of COMMD1, 
      is associated with the defective cerebral recovery from ischemic stroke in the 
      aged rats.
CI  - Copyright (c) 2021 Guo, Zhou, Li, Xiao, Zhang, Yang, Feng and Kang.
FAU - Guo, Yingjia
AU  - Guo Y
AD  - Regenerative Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Zhou, Junpeng
AU  - Zhou J
AD  - Regenerative Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Li, Xianglong
AU  - Li X
AD  - Regenerative Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu, China.
AD  - Department of Neurosurgery, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, China.
FAU - Xiao, Ying
AU  - Xiao Y
AD  - Regenerative Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Zhang, Jingyao
AU  - Zhang J
AD  - Regenerative Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Yang, Yutao
AU  - Yang Y
AD  - Regenerative Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Feng, Li
AU  - Feng L
AD  - Regenerative Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Kang, Y James
AU  - Kang YJ
AD  - Regenerative Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu, China.
AD  - Memphis Institute of Regenerative Medicine, University of Tennessee Health 
      Science Center, Memphis, TN, United States.
LA  - eng
PT  - Journal Article
DEP - 20210226
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC7953721
OTO - NOTNLM
OT  - Cu metabolism MURR domain 3
OT  - MCAO
OT  - aging
OT  - hypoxia-inducible factor-1
OT  - ischemic stroke
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/03/16 06:00
MHDA- 2021/03/16 06:01
PMCR- 2021/01/01
CRDT- 2021/03/15 06:55
PHST- 2020/12/31 00:00 [received]
PHST- 2021/02/09 00:00 [accepted]
PHST- 2021/03/15 06:55 [entrez]
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/03/16 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2021.648115 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2021 Feb 26;13:648115. doi: 10.3389/fnagi.2021.648115. 
      eCollection 2021.