PMID- 33717412
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210422
IS  - 1976-8354 (Print)
IS  - 2151-2485 (Electronic)
IS  - 1976-8354 (Linking)
VI  - 25
IP  - 1
DP  - 2021 Feb 11
TI  - Gait parameters as tools for analyzing phenotypic alterations of a mouse model of 
      Charcot-Marie-Tooth disease.
PG  - 11-18
LID - 10.1080/19768354.2021.1880967 [doi]
AB  - Charcot-Marie-Tooth disease (CMT), a genetically heterogeneous group of diseases 
      in the peripheral nervous system, is characterized by progressive and symmetrical 
      distal weakness resulting in gait abnormality. The necessity of the diagnostic 
      and prognostic biomarkers has been raised for both basic research and clinical 
      practice in CMT. Since biomarkers for animal study of CMT are limited, we 
      evaluated the feasibility of gait parameters as tool for measuring disease 
      phenotype of CMT mouse model. Using a Trembler-J (Tr-J) mouse, a CMT type 1 
      (CMT1) mouse model, we analyzed kinematic parameters such as angles of hip, knee 
      and ankle (sagittal plane), and spatial parameters including step width and 
      stride length (transverse plane). Regarding of kinematic parameters, Tr-J mice 
      exhibited less plantarflexed ankle during the swing phase and more dorsiflexed 
      ankle at the terminal stance compared to control mice. The range of motion in 
      ankle angle of Tr-J mice was significantly greater than that of control mice. In 
      spatial parameter, Tr-J mice exhibited wider step width compared to control mice. 
      These results are similar to previously reported gait patterns of CMT1 patients. 
      In comparison with other markers such as nerve conduction study and rotarod test, 
      gait parameters dynamically reflected the disease progression of CMT1 mice. 
      Therefore, these data imply that gait parameters can be used as useful tools to 
      analyzed the disease phenotype and progression during preclinical study of 
      peripheral neuropathy such as CMT.
CI  - (c) 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & 
      Francis Group.
FAU - Hwang, Sun Hee
AU  - Hwang SH
AD  - Department of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea.
FAU - Chang, Eun Hyuk
AU  - Chang EH
AD  - Samsung Biomedical Research Institute, Samsung Advanced Institute of Technology, 
      Samsung Electronics Co., Ltd., Seoul, Republic of Korea.
FAU - Kwak, Geon
AU  - Kwak G
AD  - Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 
      Seoul, Republic of Korea.
FAU - Jeon, Hyeonjin
AU  - Jeon H
AD  - Department of Biochemistry, College of Medicine, Dong-A University, Busan, 
      Republic of Korea.
AD  - Department of Translational Biomedical Sciences, Graduate School of Dong-A 
      University, Busan, Korea.
FAU - Choi, Byung-Ok
AU  - Choi BO
AD  - Department of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea.
AD  - Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 
      Seoul, Republic of Korea.
FAU - Hong, Young Bin
AU  - Hong YB
AD  - Department of Biochemistry, College of Medicine, Dong-A University, Busan, 
      Republic of Korea.
AD  - Department of Translational Biomedical Sciences, Graduate School of Dong-A 
      University, Busan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20210211
PL  - England
TA  - Anim Cells Syst (Seoul)
JT  - Animal cells and systems
JID - 101478641
PMC - PMC7935128
OTO - NOTNLM
OT  - Biomarker
OT  - Charcot-Marie-Tooth disease
OT  - gait analysis
OT  - mouse model
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2021/03/16 06:00
MHDA- 2021/03/16 06:01
PMCR- 2021/02/11
CRDT- 2021/03/15 07:01
PHST- 2021/03/15 07:01 [entrez]
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/03/16 06:01 [medline]
PHST- 2021/02/11 00:00 [pmc-release]
AID - 1880967 [pii]
AID - 10.1080/19768354.2021.1880967 [doi]
PST - epublish
SO  - Anim Cells Syst (Seoul). 2021 Feb 11;25(1):11-18. doi: 
      10.1080/19768354.2021.1880967.