PMID- 33717533
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 13
IP  - 2
DP  - 2021 Feb
TI  - The value of multidisciplinary team (MDT) management in the diagnosis and 
      treatment of primary intrathoracic synovial sarcomas: a single-center experience.
PG  - 600-612
LID - 10.21037/jtd-20-2887 [doi]
AB  - BACKGROUND: Synovial sarcoma (SS) is a rare malignant soft tissue tumor. Primary 
      intrathoracic SS is extremely rare, with limited diagnosis and treatment 
      experiences. The aim of our study was to retrospectively study the 
      clinicopathological characteristics, treatment and prognosis of primary 
      intrathoracic SS and the impact of multidisciplinary team (MDT) management in 
      diagnosis and treatment on patient prognosis. METHODS: The clinical and 
      pathological characteristics, treatment, survival and prognosis of patients with 
      primary intrathoracic SS admitted to the National Cancer Center from January 1999 
      to December 2018, as well as MDT intervention during diagnosis and treatment, 
      were retrospectively analyzed. RESULTS: Thirteen patients were enrolled, 
      including 7 (53.8%) males and 6 (46.3%) females, with primary intrathoracic SS in 
      the lung (8/13, 61.5%), mediastinum (4/13, 30.8%) and pleura (1/13, 7.7%) as 
      confirmed by morphological observation, immunohistochemical (IHC) staining and 
      fluorescence in situ hybridization (FISH). Overall, 10/13 (76.9%) patients 
      underwent surgery, and 6/10 (60.0%) received postoperative adjuvant therapy. Only 
      23.1% of patients received nonsurgical therapy. The MDT discussed and managed 
      seven patients before and/or after surgery and one patient who did not undergo 
      surgery. The estimated 3- and 5-year overall survival (OS) rates were 50.0% and 
      30.0%, respectively. Patients who were managed by an MDT had a longer median OS 
      time than those who were not (46.0 vs. 18.0 months). Age (P=0.018), tumor 
      location (P=0.029), and Ki-67 (P=0.020) were found to be significantly related to 
      OS. CONCLUSIONS: Monophasic morphology and fusion gene characteristics are the 
      main features for the diagnosis of primary intrathoracic SS. MDT management can 
      help obtain accurate diagnoses and provide reasonable therapeutic options.
CI  - 2021 Journal of Thoracic Disease. All rights reserved.
FAU - He, Huayu
AU  - He H
AD  - Department of Thoracic Surgery, National Cancer Center/National Clinical Research 
      Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Beijing, China.
FAU - Yang, Lin
AU  - Yang L
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, China.
FAU - Peng, Yue
AU  - Peng Y
AD  - Department of Thoracic Surgery, National Cancer Center/National Clinical Research 
      Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Beijing, China.
FAU - Liu, Li
AU  - Liu L
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, China.
FAU - Liu, Lei
AU  - Liu L
AD  - Department of Thoracic Surgery, National Cancer Center/National Clinical Research 
      Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Beijing, China.
FAU - Xue, Qi
AU  - Xue Q
AD  - Department of Thoracic Surgery, National Cancer Center/National Clinical Research 
      Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Beijing, China.
FAU - Gao, Shugeng
AU  - Gao S
AD  - Department of Thoracic Surgery, National Cancer Center/National Clinical Research 
      Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Beijing, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC7947479
OTO - NOTNLM
OT  - Synovial sarcoma (SS)
OT  - lung
OT  - mediastinum
OT  - multidisciplinary team (MDT)
OT  - pleura
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/jtd-20-2887). The authors have no 
      conflicts of interest to declare.
EDAT- 2021/03/16 06:00
MHDA- 2021/03/16 06:01
PMCR- 2021/02/01
CRDT- 2021/03/15 07:02
PHST- 2021/03/15 07:02 [entrez]
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/03/16 06:01 [medline]
PHST- 2021/02/01 00:00 [pmc-release]
AID - jtd-13-02-600 [pii]
AID - 10.21037/jtd-20-2887 [doi]
PST - ppublish
SO  - J Thorac Dis. 2021 Feb;13(2):600-612. doi: 10.21037/jtd-20-2887.