PMID- 33717613
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 2214-0883 (Electronic)
IS  - 2095-1779 (Print)
IS  - 2214-0883 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb
TI  - Development of an analytical method for multi-residue quantification of 18 
      anthelmintics in various animal-based food products using liquid 
      chromatography-tandem mass spectrometry.
PG  - 68-76
LID - 10.1016/j.jpha.2020.03.008 [doi]
AB  - In this study, we developed a simple screening procedure for the determination of 
      18 anthelmintics (including benzimidazoles, macrocyclic lactones, 
      salicylanilides, substituted phenols, tetrahydropyrimidines, and 
      imidazothiazoles) in five animal-derived food matrices (chicken muscle, pork, 
      beef, milk, and egg) using liquid chromatography-tandem mass spectrometry. 
      Analytes were extracted using acetonitrile/1% acetic acid (milk and egg) and 
      acetonitrile/1% acetic acid with 0.5 mL of distilled water (chicken muscle, pork, 
      and beef), and purified using saturated n-hexane/acetonitrile. A reversed-phase 
      analytical column and a mobile phase consisting of (A) 10 mM ammonium formate in 
      distilled water and (B) methanol were used to achieve optimal chromatographic 
      separation. Matrix-matched standard calibration curves (R (2) >/=0.9752) were 
      obtained for concentration equivalent to x1/2, x1, x2, x3, x4, and x5 fold the 
      maximum residue limit (MRL) stipulated by the Korean Ministry of Food and Drug 
      Safety. Recoveries of 61.2-118.4%, with relative standard deviations (RSDs) of 
      </=19.9% (intraday and interday), were obtained for each sample at three spiking 
      concentrations (x1/2, x1, and x2 the MRL values). Limits of detection, limits of 
      quantification, and matrix effects were 0.02-5.5 mug/kg, 0.06-10 mug/kg, and -98.8 
      to 13.9% (at 20 mug/kg), respectively. In five samples of each food matrix 
      (chicken muscle, pork, beef, milk, and egg) purchased from large retailers in 
      Seoul that were tested, none of the target analytes were detected. It has 
      therefore been shown that this protocol is adaptable, accurate, and precise for 
      the quantification of anthelmintic residues in foods of animal origin.
CI  - (c) 2020 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
FAU - Yoo, Kyung-Hee
AU  - Yoo KH
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.
FAU - Park, Da-Hee
AU  - Park DH
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.
FAU - Abd El-Aty, A M
AU  - Abd El-Aty AM
AD  - State Key Laboratory of Biobased Material and Green Papermaking, College of Food 
      Science and Engineering, Qilu University of Technology, Shandong Academy of 
      Science, Jinan, 250353, China.
AD  - Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 
      12211, Giza, Egypt.
AD  - Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, 
      25240, Turkey.
FAU - Kim, Seong-Kwan
AU  - Kim SK
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.
FAU - Jung, Hae-Ni
AU  - Jung HN
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.
FAU - Jeong, Da-Hye
AU  - Jeong DH
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.
FAU - Cho, Hee-Jung
AU  - Cho HJ
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.
AD  - Department of Veterinary Physiology, College of Veterinary Medicine, Konkuk 
      University, Seoul, 143-701, Republic of Korea.
FAU - Hacimuftuoglu, Ahmet
AU  - Hacimuftuoglu A
AD  - Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, 
      25240, Turkey.
FAU - Shim, Jae-Han
AU  - Shim JH
AD  - Natural Products Chemistry Laboratory, College of Agriculture and Life Sciences, 
      Chonnam National University, Gwangju, 500-757, Republic of Korea.
FAU - Jeong, Ji Hoon
AU  - Jeong JH
AD  - Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, 
      156-756, Republic of Korea.
FAU - Shin, Ho-Chul
AU  - Shin HC
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20200321
PL  - China
TA  - J Pharm Anal
JT  - Journal of pharmaceutical analysis
JID - 101579451
PMC - PMC7930640
OTO - NOTNLM
OT  - Animal-based food products
OT  - Anthelmintics
OT  - Method validation
OT  - Residue analysis
OT  - Tandem mass spectrometry
EDAT- 2021/03/16 06:00
MHDA- 2021/03/16 06:01
PMCR- 2020/03/21
CRDT- 2021/03/15 07:03
PHST- 2019/10/16 00:00 [received]
PHST- 2020/03/17 00:00 [revised]
PHST- 2020/03/18 00:00 [accepted]
PHST- 2021/03/15 07:03 [entrez]
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/03/16 06:01 [medline]
PHST- 2020/03/21 00:00 [pmc-release]
AID - S2095-1779(19)31016-0 [pii]
AID - 10.1016/j.jpha.2020.03.008 [doi]
PST - ppublish
SO  - J Pharm Anal. 2021 Feb;11(1):68-76. doi: 10.1016/j.jpha.2020.03.008. Epub 2020 
      Mar 21.