PMID- 33718087
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 2223-4691 (Print)
IS  - 2223-4691 (Electronic)
IS  - 2223-4683 (Linking)
VI  - 10
IP  - 2
DP  - 2021 Feb
TI  - Comparison of the efficacy and safety of low-intensity extracorporeal shock wave 
      therapy versus on-demand sildenafil for erectile dysfunction.
PG  - 860-868
LID - 10.21037/tau-20-1069 [doi]
AB  - BACKGROUND: Low-intensity extracorporeal shock wave therapy (Li-ESWT) is an 
      effective therapy for erectile dysfunction (ED) but is not widely recognized and 
      applied. This prospective nonrandomized study aimed to investigate the efficacy 
      and safety of Li-ESWT. METHODS: After a 4-week washout period of past ED 
      treatment, patients entered one of 2 active treatment groups, either 9-week 
      Li-ESWT or 100 mg on-demand sildenafil. Patients were evaluated in the first- and 
      third-month following initiation of treatment. The Li-ESWT protocol comprised 2 
      sessions per week for 3 weeks, which were repeated after a 3-week interval. 
      Patients in the drug group took self-administered sildenafil at a dose of 100 mg 
      before intercourse. The primary outcome was the effectiveness of Li-ESWT measured 
      by the International Index of Erectile Function-5 (IIEF-5) scores. Other 
      measurements included erection hardness score (EHS) and Self-Esteem And 
      Relationship (SEAR). RESULTS: A total of 78 participants completed the study (46 
      in the Li-ESWT group and 32 in the sildenafil group). Overall, 26.9% of the 
      participants (21/78) included were psychogenic. In the third month, the outcome 
      measured by IIEF-5 was 21.52 in the Li-ESWT group and 21.26 in the sildenafil 
      group (P>0.05). Proportion of improvement defined by minimal clinically important 
      difference (MCID) criteria was 52.2% in the Li-ESWT group and 59.4% in the 
      sildenafil group (P>0.05). The EHS and SEAR improvement was similar in the 2 
      groups (P>0.05 at baseline and third month). Transient and mild adverse events 
      were observed in both groups. CONCLUSIONS: In our study, a similar treatment 
      efficacy and safety was shown by the application of Li-ESWT as on demand 
      sildenafil.
CI  - 2021 Translational Andrology and Urology. All rights reserved.
FAU - Lei, Qi
AU  - Lei Q
AD  - Department of Urology, Peking Union Medical College Hospital, Beijing, China.
FAU - Wang, Dong
AU  - Wang D
AD  - Department of Urology, Peking Union Medical College Hospital, Beijing, China.
FAU - Liu, Chunhui
AU  - Liu C
AD  - Department of Urology, Peking Union Medical College Hospital, Beijing, China.
FAU - Ji, Zhigang
AU  - Ji Z
AD  - Department of Urology, Peking Union Medical College Hospital, Beijing, China.
FAU - Yan, Su
AU  - Yan S
AD  - Department of Urology, Peking Union Medical College Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Transl Androl Urol
JT  - Translational andrology and urology
JID - 101581119
PMC - PMC7947449
OTO - NOTNLM
OT  - Erectile dysfunction (ED)
OT  - International Index of Erectile Function-5 (IIEF-5)
OT  - low-intensity extracorporeal shock wave therapy
OT  - organic
OT  - psychogenic
OT  - sildenafil
OT  - treatment
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/tau-20-1069). The authors have no 
      conflicts of interest to declare.
EDAT- 2021/03/16 06:00
MHDA- 2021/03/16 06:01
PMCR- 2021/02/01
CRDT- 2021/03/15 07:07
PHST- 2021/03/15 07:07 [entrez]
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/03/16 06:01 [medline]
PHST- 2021/02/01 00:00 [pmc-release]
AID - tau-10-02-860 [pii]
AID - 10.21037/tau-20-1069 [doi]
PST - ppublish
SO  - Transl Androl Urol. 2021 Feb;10(2):860-868. doi: 10.21037/tau-20-1069.