PMID- 33718099 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210316 IS - 2223-4691 (Print) IS - 2223-4691 (Electronic) IS - 2223-4683 (Linking) VI - 10 IP - 2 DP - 2021 Feb TI - Giant bilateral primary scrotal lipoma along with lipomas in multiple sites of the body: a case report and literature review. PG - 983-990 LID - 10.21037/tau-20-1073 [doi] AB - Mesenchymal neoplasms of the scrotum are extremely rare in the clinical practices, in which lipoma is the most common benign neoplasm of them. Primary scrotal lipoma refers to the lipoma originated from scrotal wall. We reported a rare case of a 47-year-old man who suffered from bilateral giant primary scrotal lipoma along with lipomas in multiple sites of the body. Scrotal ultrasound indicated that huge hypoechogenic masses were observed in the bilateral scrotums. Contrast-enhanced computed tomography (CT) indicated increased fat density in the scrotal areas. Surgical resection was performed on both scrotal neoplasms. Diagnosis of lipoma was confirmed by the pathological examination through the morphological observation as well as the absence of murine double minute2 (MDM2) gene amplification in the fluorescence in situ hybridization (FISH) test. After five months of follow-up, the wound of the patient recovered well and no sign of local recurrence was observed. Based on the literature review, very few cases of primary scrotal lipoma were reported in the scientific literature up to date, and this is the first report of bilateral primary scrotal lipoma along with multiple lipomas of the body. We presented this case as a rare phenomenon. Although primary scrotal lipoma is rare, clinicians should take it into account when encountering similar scrotal lesions and know the methods for diagnosis and how to make differential diagnosis with other diseases, which is associated with the patient's treatment strategy and prognosis. CI - 2021 Translational Andrology and Urology. All rights reserved. FAU - Zheng, Weitao AU - Zheng W AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Shi, Ming AU - Shi M AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Li, Tao AU - Li T AD - Department of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, China. FAU - Xu, Hang AU - Xu H AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Chen, Zeyu AU - Chen Z AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Wang, Xingyuan AU - Wang X AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Bai, Shengjiang AU - Bai S AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Le, Weizhen AU - Le W AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Yang, Lu AU - Yang L AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. FAU - Wei, Qiang AU - Wei Q AD - Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. LA - eng PT - Case Reports PL - China TA - Transl Androl Urol JT - Translational andrology and urology JID - 101581119 PMC - PMC7947464 OTO - NOTNLM OT - Primary scrotal lipoma OT - case report OT - diagnosis OT - treatment COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tau-20-1073). The authors have no conflicts of interest to declare. EDAT- 2021/03/16 06:00 MHDA- 2021/03/16 06:01 PMCR- 2021/02/01 CRDT- 2021/03/15 07:07 PHST- 2021/03/15 07:07 [entrez] PHST- 2021/03/16 06:00 [pubmed] PHST- 2021/03/16 06:01 [medline] PHST- 2021/02/01 00:00 [pmc-release] AID - tau-10-02-983 [pii] AID - 10.21037/tau-20-1073 [doi] PST - ppublish SO - Transl Androl Urol. 2021 Feb;10(2):983-990. doi: 10.21037/tau-20-1073.