PMID- 33718407
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - TGF-beta1 Signaling: Immune Dynamics of Chronic Kidney Diseases.
PG  - 628519
LID - 10.3389/fmed.2021.628519 [doi]
LID - 628519
AB  - Chronic kidney disease (CKD) is a major cause of morbidity and mortality 
      worldwide, imposing a great burden on the healthcare system. Regrettably, 
      effective CKD therapeutic strategies are yet available due to their elusive 
      pathogenic mechanisms. CKD is featured by progressive inflammation and fibrosis 
      associated with immune cell dysfunction, leading to the formation of an 
      inflammatory microenvironment, which ultimately exacerbating renal fibrosis. 
      Transforming growth factor beta1 (TGF-beta1) is an indispensable immunoregulator 
      promoting CKD progression by controlling the activation, proliferation, and 
      apoptosis of immunocytes via both canonical and non-canonical pathways. More 
      importantly, recent studies have uncovered a new mechanism of TGF-beta1 for de novo 
      generation of myofibroblast via macrophage-myofibroblast transition (MMT). This 
      review will update the versatile roles of TGF-beta signaling in the dynamics of 
      renal immunity, a better understanding may facilitate the discovery of novel 
      therapeutic strategies against CKD.
CI  - Copyright (c) 2021 Tang, Chan, Zhang, Garcia Cordoba, Zhang, To, Leung, Lan and 
      Tang.
FAU - Tang, Philip Chiu-Tsun
AU  - Tang PC
AD  - State Key Laboratory of Translational Oncology, Department of Anatomical and 
      Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong.
FAU - Chan, Alex Siu-Wing
AU  - Chan AS
AD  - Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hung 
      Hom, Hong Kong.
FAU - Zhang, Cai-Bin
AU  - Zhang CB
AD  - State Key Laboratory of Translational Oncology, Department of Anatomical and 
      Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong.
FAU - Garcia Cordoba, Cristina Alexandra
AU  - Garcia Cordoba CA
AD  - State Key Laboratory of Translational Oncology, Department of Anatomical and 
      Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong.
FAU - Zhang, Ying-Ying
AU  - Zhang YY
AD  - Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, 
      Shanghai, China.
FAU - To, Ka-Fai
AU  - To KF
AD  - State Key Laboratory of Translational Oncology, Department of Anatomical and 
      Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong.
FAU - Leung, Kam-Tong
AU  - Leung KT
AD  - Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong 
      Kong.
FAU - Lan, Hui-Yao
AU  - Lan HY
AD  - Department of Medicine and Therapeutics, Li Ka Shing Institute of Health 
      Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.
AD  - Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney 
      Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong.
FAU - Tang, Patrick Ming-Kuen
AU  - Tang PM
AD  - State Key Laboratory of Translational Oncology, Department of Anatomical and 
      Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210225
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC7948440
OTO - NOTNLM
OT  - chronic kidney disease
OT  - immunity
OT  - kidney fibrosis
OT  - renal inflammation
OT  - transforming growth factor beta
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/03/16 06:00
MHDA- 2021/03/16 06:01
PMCR- 2021/02/25
CRDT- 2021/03/15 07:09
PHST- 2020/11/12 00:00 [received]
PHST- 2021/01/21 00:00 [accepted]
PHST- 2021/03/15 07:09 [entrez]
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/03/16 06:01 [medline]
PHST- 2021/02/25 00:00 [pmc-release]
AID - 10.3389/fmed.2021.628519 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2021 Feb 25;8:628519. doi: 10.3389/fmed.2021.628519. 
      eCollection 2021.